Table of Contents
- Best NAD+ Supplement for Weight Loss: Our Top Picks
- How NAD+ Supports Weight Loss
- Key Benefits of NAD+ for Weight and Metabolism
- Who Should Consider a NAD+ Supplement for Weight Loss?
- How to Choose the Right NAD+ Supplement for Weight Loss
- Tips to Maximize Results With NAD+ Supplements
- Are NAD+ Supplements Safe for Weight Loss?
- Conclusion
- FAQs
NAD+ supplements may help with weight loss by improving energy use, speeding up metabolism, and supporting fat burning. Research shows that NAD+ precursors like NMN and NR can improve fat metabolism, insulin response, and mitochondrial function.
Below, you'll find 5 of the best NAD+ supplements for weight loss in 2025. These picks are based on clean ingredients, smart delivery methods, and real science.
Whether you're aiming to lose belly fat or just feel more energized, these options can support your goals.
Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*
NMN + RESVERATROL
Best NAD+ Supplement for Weight Loss: Our Top Picks
Best Overall: Omre NMN + Resveratrol
Best High-Dose NMN: ProHealth NMN Pro Powder
Best Clinically Proven NR: Tru Niagen
Best for Active Lifestyles: Thorne NiaCel 400
Best Budget Option: Genex NMN Capsules
Looking for a quick comparison before diving into the details? Here's how these NAD+ supplements stack up when it comes to form, dosage, and what they’re best for:
1. Best Overall – Omre NMN + Resveratrol
Omre NMN + Resveratrol stands out as one of the most well-rounded NAD+ supplements on the market. It combines two powerful ingredients, NMN and Resveratrol, that are often studied for their roles in energy production, metabolic health, and cellular repair.
If you're looking to support weight loss and healthy aging at the same time, this is a solid choice.
Each serving gives you 500 mg of ultra-pure NMN and 500 mg of Trans-Resveratrol, along with BioPerine® to help your body absorb the nutrients more effectively.
Resveratrol itself has been linked to improved fat metabolism and better mitochondrial function in some studies, while NMN is known to help raise NAD+ levels and support energy use.
The bottle contains a 30-day supply and costs around $59.97. It’s made in a GMP-certified facility and third-party tested, so you’re getting clean, reliable ingredients without extra fillers.
Taking it with a small amount of fat, like during breakfast or lunch, can help with absorption.
Pros:
High-quality NMN and Resveratrol combo
BioPerine® for better absorption
Third-party tested for purity
Helpful for energy and metabolism
Cons:
Needs to be taken with fat for best results
Capsule format may not work for everyone
2. Best High-Dose NMN – ProHealth NMN Pro Powder
If you’re after a high dose of NMN to support metabolism and fat-burning, ProHealth’s NMN Pro Powder is a great option.
It delivers 1,000 mg of NMN per serving and comes in a powder format that you can take sublingually (under the tongue) for faster absorption.
This pure NMN powder is ideal for those who want to take control over their dosing, especially if you're already working out or following a weight loss routine.
Studies have shown that NMN can help improve insulin sensitivity, reduce liver fat, and even support lean muscle mass, all of which are useful when trying to lose weight (1).
A 30-serving tub costs around $79.80, which makes it a bit more of an investment. But the quality is high, and the brand uses third-party testing and GMP-certified manufacturing. It’s unflavored, easy to mix into your routine, and doesn’t include any fillers.
Pros:
1,000 mg of NMN per serving
Sublingual delivery for quick absorption
Customizable dosing
Solvent-free and lab-tested
Cons:
More expensive than capsules
Powder form may be less convenient for some
3. Best Clinically Proven NR – Tru Niagen
Tru Niagen is one of the most science-backed NAD+ supplements available, using a patented form of nicotinamide riboside (NR) called Niagen®.
It’s been studied in multiple human trials, showing that it can increase NAD+ levels by more than 50% in just two weeks (2).
This supplement supports healthy metabolism and may help with energy production, fat oxidation, and even appetite control.
While NR is a different precursor than NMN, it's well-researched and often preferred by those who want a straightforward, clinically validated formula.
Each capsule delivers 300 mg of NR and costs about $47.50 for a 30-day supply. There are no added ingredients, making it a clean and simple choice for those who want a minimalist approach.
It's also FDA GRAS-certified and made in NSF-certified facilities.
Pros:
Clinically shown to raise NAD+ quickly
Simple and clean ingredient profile
FDA GRAS and NSF-certified
Backed by human research
Cons:
Some users may need higher doses
No synergistic ingredients like Resveratrol
4. Best for Active Lifestyles – Thorne NiaCel 400
If you’re working out regularly or following a physically demanding routine, Thorne NiaCel 400 could be the right fit.
It contains 415 mg of nicotinamide riboside (NR) and adds TMG (trimethylglycine), which helps support methylation, important for maintaining healthy NAD+ cycles.
What makes this one stand out for active users is its NSF Certified for Sport label, meaning it’s been tested for banned substances and is safe for athletes.
NR has been shown to improve mitochondrial function, which may help your body use fat for energy and recover better from exercise.
A 30-serving bottle costs around $67.62. While it doesn’t include antioxidants like Resveratrol, its targeted formula makes it a good pick for those focused on performance, endurance, and healthy fat metabolism.
Pros:
High-dose NR with TMG for support
NSF Certified for Sport
Great for workout recovery and energy
Clean, professional-grade manufacturing
Cons:
More expensive than basic NR supplements
No antioxidants or extra ingredients
5. Best Budget Option – Genex NMN Capsules
For those looking to try NAD+ supplementation without spending too much, Genex NMN Capsules offer good value.
Each capsule contains 250 mg of NMN, and the formula is third-party tested to make sure it’s safe and free from unwanted additives.
While the dose is lower than some premium brands, it’s enough for beginners to start with and see how their body responds.
You can always take two capsules per day if needed, and the price makes that flexible. At $29.99 for 60 capsules, it’s one of the most affordable picks.
This is a straightforward product without extras, but if you’re just starting your NAD+ journey or want to keep costs low while supporting your metabolism, Genex is a solid entry-level option.
Pros:
Affordable and beginner-friendly
250 mg of pure NMN per capsule
Easy to scale up dose
Clean and third-party tested
Cons:
Lower dose compared to other options
No added ingredients for enhanced effects
How NAD+ Supports Weight Loss
NAD+ (short for Nicotinamide Adenine Dinucleotide) plays a big part in how your body turns food into energy.
It’s found in every cell and helps with important processes like metabolism, energy production, and fat breakdown. But as we get older, our natural NAD+ levels drop, which can lead to slower metabolism and more fat storage.
A 2022 study in Experimental Gerontology found that NAD+ levels can fall by more than 50 percent between early adulthood and older age (3).
This drop doesn’t just affect your energy. It also makes it harder for your cells to burn fat and respond to insulin properly, two key parts of managing weight.
When NAD+ levels are low, your mitochondria, your cells’ energy engines, don’t work as well. That can leave you feeling more tired, make your workouts feel harder, and slow down your body’s ability to burn calories.
Raising NAD+ with supplements like NMN or NR may help support better fat metabolism by making your mitochondria work more efficiently.
NAD+ also supports sirtuins, a group of proteins that help control how your body stores and burns fat.
These proteins play a role in metabolic health and are closely linked to insulin sensitivity, fat-burning, and even aging. Without enough NAD+, sirtuins can’t do their job properly.
This is why many researchers are looking at NAD+ precursors as a way to support healthy weight. While NAD+ supplements won’t melt fat overnight, they may help your body do what it’s supposed to: burn energy, control appetite, and keep metabolism running smoothly.
NMN + RESVERATROL
Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*
Key Benefits of NAD+ for Weight and Metabolism
NAD+ does more than just fuel your cells. It helps your body manage fat, control blood sugar, and fight the effects of inflammation. Here's a closer look at how it works:
Boosts Fat-Burning and Thermogenesis
NAD+ helps activate brown fat, the type of fat that burns calories to create heat. This process is called thermogenesis, and it’s one of the ways your body maintains energy balance.
Brown fat is rich in mitochondria and can help increase your calorie burn throughout the day, even when you're not exercising.
A study found that NAD+ also plays a role in “browning” white fat. This means turning regular white fat cells into beige fat cells that behave more like brown fat (4).
Beige fat is more active and burns more calories, which can make a real difference when you're trying to lose stubborn fat.
By raising NAD+ levels, your body may become better at using stored fat for energy. That can help you burn more calories naturally, especially when combined with regular movement and a healthy diet.
Improves Insulin Sensitivity and Glucose Control
One major reason people struggle to lose weight is poor insulin sensitivity. When your cells stop responding well to insulin, your body stores more fat and has a harder time using sugar for fuel.
NAD+ helps fix this by improving how your cells respond to insulin and how your body handles blood sugar.
A study in IUBMB Life showed that NMN supplementation in mice improved glucose tolerance and reduced fat buildup, including in the liver (5).
It also helped protect the pancreas and enhanced insulin secretion, two things that are vital for keeping your metabolism on track.
Better insulin sensitivity doesn’t just help with weight. It also means fewer energy crashes, more stable moods, and less fat storage over time. Supporting healthy NAD+ levels may be one way to help your body respond to food in a smarter way.
Reduces Inflammation in Fat Tissue
Inflammation in fat tissue is a hidden problem for many people. When fat cells become inflamed, they stop working properly and release signals that make it harder to lose weight.
NAD+ helps your body clear out damaged cells and reduce low-grade inflammation that often builds up with age or poor diet.
Research published in Frontiers in Nutrition found that NAD+ precursors were associated with a reduced body mass index (BMI) and improved adiponectin levels, a hormone involved in regulating fat metabolism and controlling inflammation (6).
Higher adiponectin levels are often seen in leaner individuals and are associated with better metabolic health.
By calming inflammation and improving fat cell function, NAD+ may help your body stay more responsive to weight loss efforts. It supports healthier fat storage, less bloating, and a more efficient way to burn calories instead of storing them.
Who Should Consider a NAD+ Supplement for Weight Loss?
NAD+ supplements aren’t just for athletes or people chasing longevity. If your metabolism feels sluggish or weight loss has hit a wall, they might be worth considering.
Here’s who may benefit the most:
Adults over 30: NAD+ levels start to drop as early as your 30s, which can slow down metabolism and energy production. Supporting NAD+ early on may help keep your fat-burning systems working well.
People struggling with low energy: Feeling tired even after sleeping enough? Low NAD+ could be making it harder for your cells to produce energy efficiently.
Anyone facing weight plateaus: If you’re eating well and staying active but still not seeing results, NAD+ precursors like NMN or NR might help your body respond better to those efforts.
Those with insulin resistance or prediabetes: NAD+ plays a key role in blood sugar control. Boosting levels may support healthier insulin sensitivity and fat metabolism.
Busy, stressed adults: Chronic stress wears down your cells over time. NAD+ supplements may help replenish what stress takes away and keep your metabolism steady.
How to Choose the Right NAD+ Supplement for Weight Loss
Not all NAD+ supplements are the same, especially when it comes to supporting weight loss. Some use NMN, others use NR, and a few include extra ingredients that may help with fat metabolism or energy. Choosing the right one depends on your goals, lifestyle, and how your body responds.
Here are a few things to look for when picking a supplement:
Check the form of NAD+: NMN and NR are the most researched options. NMN may work faster for metabolism, while NR has more human studies behind it.
Look at the dose: A good weight-loss-friendly dose is usually 300 to 1000 mg per day. Higher doses may be more helpful for active individuals or those over 40.
See if it includes add-ons like Resveratrol or TMG: Ingredients like Resveratrol may improve fat metabolism, and TMG supports methylation, which helps your body recycle NAD+.
Pick a clean and tested brand: Choose supplements made in GMP-certified facilities and third-party tested. This helps make sure you're getting what’s on the label without unwanted fillers.
Think about format: Capsules are convenient, but powders or sublingual forms may absorb better. Go with what fits best into your daily routine.
Tips to Maximize Results With NAD+ Supplements
Taking a supplement is just one part of the picture. Here are a few tips to help your NAD+ supplement work better:
Take it consistently: Whether it’s NMN or NR, daily use matters. Most benefits build up over weeks of regular intake.
Pair it with healthy fats: If your supplement contains Resveratrol or is fat-soluble, taking it with food that has healthy fats (like avocado or olive oil) can improve absorption.
Exercise regularly: Physical activity naturally increases NAD+ levels, especially endurance or strength training. Combining both can give you better results.
Try intermittent fasting or eat lighter meals: Calorie restriction and fasting are both linked to higher NAD+ activity and improved metabolic health.
Cut down on alcohol: Alcohol lowers NAD+ levels and can make your supplements less effective. Reducing intake may help support better results.
Are NAD+ Supplements Safe for Weight Loss?
Yes, NAD+ supplements are generally safe for weight loss when used at recommended doses. Most people tolerate NMN and NR well, especially when taken with food or water.
Some people may notice mild side effects when first starting:
Nausea or stomach upset
Headache
Bloating or gas
Mild fatigue in the first few days (as the body adjusts)
These effects usually go away as your body gets used to the supplement. Still, if you’re taking medications or managing a health condition, it’s always smart to talk to your doctor first.
Pregnant or breastfeeding individuals should avoid NAD+ supplements unless approved by a healthcare provider.
Conclusion
NAD+ supplements may not be a magic solution for weight loss, but they can support your body’s natural fat-burning, metabolism, and energy systems, especially if your levels have dropped with age or stress.
Research around NMN and NR continues to grow, and early signs show they may help with fat oxidation, insulin sensitivity, and cellular repair.
If you're ready to try a clean, research-backed option, Omre NMN + Resveratrol is one of the best NAD+ supplements available. It offers well-dosed ingredients that may support weight goals while also helping with energy and recovery.
Check availability to see if it's the right fit for your routine.
FAQs
Can NAD+ supplements help with belly fat?
NAD+ supplements may help reduce belly fat by improving how your body uses insulin and burns fat. When insulin sensitivity gets better, your body stores less fat in the abdominal area.
What’s better for fat loss, NMN or NR?
Both NMN and NR raise NAD+ levels, but NMN might be more effective for fat loss based on early research. It’s absorbed quickly and may offer stronger support for metabolism and energy use.
Do NAD supplements give you energy?
Yes, NAD+ supplements can support energy by helping your cells produce ATP, which is your body’s main fuel source. Many people say they feel more alert and less tired after a few weeks.
Is it safe to take NAD+ supplements daily?
For most people, yes. Daily use of NMN or NR is common in studies and considered safe when taken as directed. If you have health conditions or take medications, talk to your doctor first.
How long does it take to see results?
You may notice better energy in 2 to 4 weeks. For fat loss or changes in body composition, it usually takes 8 to 12 weeks of consistent use, especially with exercise and a balanced diet.