Top 9 Pure NAD Supplements in 2025 for Energy and Healthy Aging

What is NAD+?

NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every living cell, playing a key role in energy production, DNA repair, and cellular health. It naturally declines as we age, which may contribute to fatigue, slower recovery, and signs of aging.

NAD+ acts like a cellular workhorse, helping enzymes in your body perform vital tasks. It powers the mitochondria, the “batteries” of your cells, and supports DNA repair processes. Without it, cellular energy production slows, and oxidative stress can increase, potentially speeding up aging.

While our bodies produce NAD+ naturally, aging, stress, and environmental factors can deplete its levels. This is where supplementation may come into play, helping to replenish NAD+ and support healthy cellular function.

Why Take a Pure NAD Supplement?

As NAD+ levels naturally decrease with age, adding a supplement might provide support for overall well-being. It's important to note that many studies on NAD+ have been conducted on animals or in small-scale lab settings, so more human research is needed to confirm these effects. Still, current findings suggest several potential benefits:

• Energy Support: NAD+ precursors may help mitochondria, the cell's energy producers, work more efficiently (1).

• Cellular Health: Some research indicates NAD+ could play a role in supporting DNA repair, potentially helping to combat aging at a cellular level (2).

• Cognitive Function: Early studies suggest NAD+ precursors might support memory and brain health, though findings are still preliminary (3).

• Healthy Aging: Maintaining NAD+ levels is thought to contribute to aging processes that are more balanced and less disruptive to overall health (4).

• Exercise Recovery: Initial research hints that NAD+ may support muscle repair and endurance, though more evidence is needed (5).

While the science is promising, it’s always a good idea to approach new supplements with realistic expectations and consult a healthcare provider for personalized advice.

Types of NAD Supplements

Direct NAD+ supplementation, while appealing, comes with some challenges. NAD+ is a relatively large molecule, and studies indicate that its absorption and effective utilization within cells may be limited, even when delivered intravenously. 

This is why researchers often recommend precursors like Nicotinamide Mononucleotide (NMN) or Nicotinamide Riboside (NR), which the body can convert into NAD+. Among these, NMN stands out as a favorite due to its extensive research and direct pathway to boosting NAD+ levels.

Pure NAD+

Pure NAD+ supplements aim to directly increase NAD+ levels in the body. While they sound ideal, the large molecule size means absorption may not be as effective as with precursors (6). 

However, they are still used in certain therapeutic or research contexts and may hold promise with continued development.

Nicotinamide Riboside (NR)

Nicotinamide Riboside is a well-studied precursor to NAD+ that is often praised for its bioavailability. It converts into NAD+ through a two-step process, supporting cellular energy and repair. 

NR is commonly found in trusted, research-backed products and offers a convenient option for those seeking a simple capsule form.

Nicotinamide Mononucleotide (NMN)

NMN has gained significant attention due to its direct role in the NAD+ production pathway. Studies suggest it may be one of the most efficient precursors, and its absorption through a specific transporter (Slc12a8) adds to its appeal. 

Many users and researchers favor NMN for its strong track record and emerging evidence supporting its effectiveness.

Liposomal NAD+ or Precursors

Liposomal delivery systems are marketed as a way to improve the bioavailability of NAD+ or its precursors. While liposomal formulations may enhance absorption to some degree, there is currently limited evidence to suggest they provide a significant advantage over traditional forms. 

As such, they might be an option, but it’s worth keeping expectations realistic.

Top Pure NAD Supplements to Consider in 2025

Here are some of the top pure NAD supplements worth exploring this year:

• Omre NMN + Resveratrol

• Tru Niagen

• Elysium Basis

• NMN Pro Powder by ProHealth

• Genex NMN Capsules

• Quicksilver Scientific NAD+ Gold

• Renue By Science NR Powder

• Thorne NiaCel 400

• Life Extension NAD+ Cell Regenerator

1. Omre NMN + Resveratrol

The Omre NMN + Resveratrol supplement offers a winning combination of high-purity NMN and Resveratrol at 500 mg each per serving. 

This supplement shines not only in its ingredient quality—99% pure NMN and 98% pure Resveratrol—but also in its attention to maximizing absorption by including BioPerine®, which can enhance Resveratrol absorption significantly. 

The two-capsule daily dose fits well into research-backed ranges, making it a smart choice for those looking to support their cellular health.

Priced at $59.97 for a 30-day supply, it delivers value for the quality it offers. The recommendation to pair it with a small amount of fat for better Resveratrol absorption may add a step, but it’s a minor inconvenience for those serious about getting the most out of their supplement. The transparent labeling, lack of fillers, and third-party testing further inspire confidence in the product.

Pros:

• High purity (99% NMN, 98% Resveratrol) ensures premium quality.

• Includes BioPerine® to boost Resveratrol absorption.

• Research-backed dosing with 500 mg of each ingredient.

• Affordable for the quality offered.

Cons:

• Requires fat intake for Resveratrol absorption.

• Capsules may not appeal to those who prefer powders or liquids.

2. Tru Niagen

Tru Niagen’s Nicotinamide Riboside (NR) supplement has built a solid reputation as a clinically proven option for increasing NAD+ levels. It’s been shown to raise NAD+ by over 50% in just two weeks of daily use, thanks to its patented Niagen ingredient. 

Each capsule contains 300 mg of NR, and with a vegan, allergen-free formula, it caters to a wide audience.

This product is ideal for those who value safety and rigorous research. Tru Niagen has undergone multiple clinical trials and received regulatory acceptance by the FDA as a GRAS (Generally Recognized As Safe) supplement. 

At around $47.50 per 30-day supply, it offers good value, though higher doses may be necessary for optimal results in some individuals.

Pros:

• Clinically proven to increase NAD+ levels by over 50%.

• Backed by decades of research and numerous clinical trials.

• Vegan, allergen-free, and third-party tested.

• Trusted by healthcare professionals and researchers.

Cons:

• Higher doses (up to 1000 mg) may be needed for some users.

• Lacks additional synergistic ingredients like Resveratrol.

3. Elysium Basis

Elysium Basis takes NAD+ supplementation a step further by combining 250 mg of Nicotinamide Riboside (NR) with 50 mg of Pterostilbene, a potent antioxidant.

This pairing is designed to support DNA repair, mitochondrial health, and overall cellular energy. With NSF Certified for Sport certification, it’s an excellent choice for athletes and active individuals.

Priced at $54 for a 30-day supply, it’s moderately affordable, considering its dual-action formula. The clinical evidence backing a 40% boost in NAD+ levels makes it a reliable option, though the NR dose might be on the lower end for some. 

The inclusion of Pterostilbene adds an edge, supporting cellular defense against oxidative stress.

Pros:

• Combines NR with Pterostilbene for enhanced benefits.

• NSF Certified for Sport, ensuring quality and safety.

• Backed by clinical research showing a 40% increase in NAD+.

• Trusted by scientists and researchers worldwide.

Cons:

• NR dose is lower compared to some competitors.

• Slightly higher price point for the amount of NR provided.

4. NMN Pro Powder by ProHealth

ProHealth’s NMN Pro Powder is a standout choice for those who prefer NMN as their NAD+ precursor. Clinically proven to increase NAD+ levels by 38%, this sublingual powder offers a unique delivery method that enhances bioavailability.

Each serving provides 1000 mg of NMN, making it one of the highest-dose options available.

At $79.80 for 30 servings, it’s priced on the higher end, but the quality justifies the cost. The powder is solvent-free and made in a GMP-certified facility, ensuring purity and safety. 

It’s especially ideal for users who prefer sublingual administration for faster results.

Pros:

• Clinically proven to increase NAD+ by 38%.

• High-dose (1000 mg) sublingual powder for better absorption.

• Solvent-free and rigorously tested for purity.

• Produced in a GMP-certified facility.

Cons:

• Higher price point compared to other forms.

• Powder format may not be convenient for everyone.

5. Genex NMN Capsules

Genex NMN capsules are a budget-friendly yet effective option for NAD+ support. Each capsule contains 250 mg of NMN, and with 60 capsules per bottle at $29.99, it’s one of the most affordable ways to start an NMN regimen.

Despite its lower price, it’s third-party tested to ensure quality and safety.

This product is perfect for beginners or those looking for a cost-effective introduction to NAD+ supplements. 

However, users seeking higher doses might find themselves taking multiple capsules daily.

Pros:

• Affordable price point at $29.99 per bottle.

• Provides 250 mg of NMN per capsule.

• Third-party tested for safety and purity.

• Convenient capsule format.

Cons:

• Lower dose per capsule compared to some competitors.

• May require multiple capsules for higher dosing needs.

NMN + RESVERATROL

Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*

Shop NMN + RESVERATROL

Shop NMN + RESVERATROL

6. Quicksilver Scientific NAD+ Gold

Quicksilver Scientific NAD+ Gold offers a groundbreaking approach with its liposomal NMN formulation. This method allows for rapid absorption, making it a great choice for those seeking fast results.

Each 1 mL serving delivers 50 mg of NMN, paired with Trimethylglycine (TMG) for additional methylation support.

Priced at $68.50 for a 50-serving bottle, it provides flexibility for users who prefer smaller, more frequent doses. 

However, the per-serving dose may be too low for some, requiring higher quantities for noticeable benefits.

Pros:

• Liposomal delivery system for rapid absorption.

• Includes TMG for methylation support.

• Flexible dosing with a liquid format.

• Portable and easy to use.

Cons:

• Lower dose per serving (50 mg of NMN).

• Higher cost for those needing larger doses.

7. Renue By Science NR Powder

Renue By Science’s NR Powder provides 1000 mg of Nicotinamide Riboside (NR) per serving in a convenient sublingual powder format.

This high-strength formula is ideal for those looking to quickly boost their NAD+ levels while supporting mitochondrial function and sirtuin activation.

At $109 for 60 servings, it’s on the pricier side, but the potent dose and sublingual delivery make it worth considering. 

The citrus burst flavor adds a pleasant twist, making it easy to incorporate into your routine.

Pros:

• High-strength formula with 1000 mg of NR per serving.

• Sublingual delivery for enhanced absorption.

• Supports mitochondrial function and sirtuin activation.

• Citrus burst flavor for a pleasant experience.

Cons:

• Expensive at $109 per bottle.

• Powder format may not suit everyone’s preferences.

8. Thorne NiaCel 400

Thorne NiaCel 400 is a high-quality Nicotinamide Riboside (NR) supplement designed to support healthy aging, cellular energy production, and mitochondrial function. Each capsule delivers 415 mg of NR, making it a potent option for increasing NAD+ levels.

Thorne’s reputation for rigorous testing and its NSF Certified for Sport certification ensures the product is safe and effective, appealing to athletes and health-conscious individuals alike.

This supplement goes beyond just supporting NAD+ production. It is formulated to protect the body against stressors that accelerate aging and contributes to overall wellness by promoting exercise efficiency and regulating the sleep-wake cycle. 

The inclusion of a unique, exclusive form of NR enhances its appeal. While the $67.62 price tag is higher than some alternatives, it reflects the premium quality and effectiveness of the product.

Pros:

• High-dose (415 mg) NR for effective NAD+ support.

• NSF Certified for Sport, ensuring safety and quality.

• Supports cellular defense, energy production, and exercise efficiency.

• Trusted for rigorous testing and high manufacturing standards.

Cons:

• Higher price point compared to other NR options.

• Does not include additional synergistic ingredients like Resveratrol.

9. Life Extension NAD+ Cell Regenerator

Life Extension NAD+ Cell Regenerator provides 300 mg of Nicotinamide Riboside per vegetarian capsule, offering an accessible and effective way to support NAD+ levels. 

This supplement is designed to combat the age-related decline in NAD+, promoting energy production and healthy cellular metabolism. The simplicity of its formula makes it a great entry-level option for those new to NAD+ supplementation.

Priced at $36.45 for a 30-day supply, it’s one of the more affordable options without compromising on quality. It’s Non-GMO and uses NIAGEN®, a patented and well-researched form of NR. 

While it doesn’t contain additional ingredients like TMG or Resveratrol, it remains a solid choice for those looking for a straightforward, cost-effective NAD+ boost.

Pros:

• Affordable price at $36.45 for a 30-day supply.

• Contains 300 mg of NIAGEN®, a patented form of Nicotinamide Riboside.

• Non-GMO and vegetarian-friendly.

• Simple, no-frills formula suitable for beginners.

Cons:

• Lacks additional supportive ingredients for enhanced benefits.

• Lower dose compared to some premium competitors.

How to Choose the Right NAD Supplement

Selecting the right NAD supplement can feel overwhelming with so many options available. Here are some key factors to consider when making your choice:

• Form of Supplement: Decide between pure NAD+, NMN, NR, or combination formulas. Both NMN and NR are widely available in capsule form, but NMN is often favored for its research-backed efficiency, while NR is also well-studied and provides a convenient option.

• Bioavailability: Look for products with delivery mechanisms like sublingual or liposomal options, but keep in mind that these may not always provide a dramatic edge.

• Third-Party Testing: Choose supplements that are third-party tested for purity and potency to ensure you’re getting a high-quality product.

• Dosage and Usage: Check the dosage per serving to match your needs. Some products provide flexibility with customizable doses, while others offer a set daily amount.

• Budget: Prices vary widely. Consider how much you're comfortable spending monthly for a high-quality supplement.

• Additional Ingredients: Some supplements include synergistic components like Resveratrol or TMG. These extras may offer additional benefits depending on your health goals.

Potential Side Effects and Safety Concerns

NAD+ supplements are generally well-tolerated when taken at the recommended dosage, with mild side effects reported in some cases (7).

For most users, NAD supplements cause no major issues when used appropriately. However, some individuals may experience mild symptoms such as nausea, headache, or digestive discomfort, particularly when starting a new supplement. 

These side effects typically subside as your body adjusts.

It’s important to stick to the recommended dose and consult with a healthcare professional, especially if you’re pregnant, breastfeeding, or taking other medications. 

While studies on NAD+ supplements are promising, long-term research on high-dose usage is still evolving, so taking them under medical guidance is always a good idea.

Who Should Consider NAD Supplements?

NAD supplements might be a good fit for individuals seeking to support their cellular health or address the effects of aging. Here are some groups who may benefit:

• Adults Over 30: NAD+ levels naturally decline with age, making supplementation potentially helpful.

• Active Individuals: Those looking to support recovery after exercise or improve endurance.

• Individuals with Stressful Lifestyles: People dealing with prolonged stress that may impact cellular health.

• Health-Conscious Individuals: Anyone aiming to maintain long-term wellness and support healthy aging.

• Those Experiencing Fatigue: People seeking to support energy production and daily vitality.

Conclusion

NAD+ plays a vital role in supporting energy production, DNA repair, and cellular health, all of which contribute to aging gracefully. 

Supplements like NMN, NR, and liposomal options provide various ways to replenish NAD+ levels effectively. 

While the market offers plenty of choices, selecting the right one comes down to your individual needs, preferences, and budget.

For those looking for a trusted, high-purity option, Omre NMN + Resveratrol stands out with its thoughtful formulation and research-backed ingredients. 

If you're interested in giving it a try, you can check availability.