Table of Contents
- What is NAD+ and Why is it Important?
- What is Liposomal NAD+?
- Why Liposomal NAD+ Might Not Be the Best Choice
- How Does Liposomal NAD+ Compare to Regular NAD+?
- Top Potential Benefits of NAD+
- Risks and Side Effects of NAD+ Supplements
- Who Can Benefit from NAD+ Precursors?
- What is the Best Form of NAD+?
- How to Take NMN for Best Results
- Can You Get NAD+ from Food?
- Best NAD+ Supplements to Try
- Conclusion
Feeling low on energy and searching for something to recharge your batteries? NAD+ supplements are a hot topic, thanks to their potential to support energy production, cellular repair, and healthy aging.
But let’s clear something up: the true magic lies not in NAD+ itself but in its precursors like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside).
These are the key players when it comes to replenishing NAD+ in the body.
So, why all the buzz about NAD+? And where does liposomal technology fit into this? Let’s dig into the facts.
NMN + RESVERATROL
Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*
What is NAD+ and Why is it Important?
NAD+ (nicotinamide adenine dinucleotide) is like the fuel your body needs to keep its engine running smoothly. Found in every living cell, this coenzyme plays a central role in converting the food you eat into energy, repairing DNA, and maintaining brain health. Without it, cellular processes slow down, leaving you feeling drained and sluggish.
Think of NAD+ as the oil that keeps your body’s engine running. It not only powers your cells but also helps them adapt to stress and recover from daily wear and tear.
The downside? NAD+ levels naturally decline as we age. This drop has been linked to everything from fatigue to cognitive decline.
The good news is that your body can rebuild its NAD+ levels using precursors like NMN and NR. These molecules are easily absorbed and converted into NAD+, giving your cells the support they need to function at their best (1).
What is Liposomal NAD+?
Liposomal NAD+ is often marketed as a smarter way to supplement NAD+, but there’s a catch. While liposomal technology works wonders for certain fat-soluble nutrients like Resveratrol, it’s less impactful for water-soluble compounds like NAD+ precursors.
The idea is that wrapping the molecule in a fat-based bubble, or liposome, protects it from breaking down during digestion. However, research shows NAD+ itself isn’t well-absorbed, whether it’s liposomal or not.
What makes the difference? Precursors like NMN and NR. NMN, for example, has specific transporters that allow it to enter cells directly and convert into NAD+ (2).
This makes it a more efficient and reliable choice for supporting your body’s NAD+ needs.
Why Liposomal NAD+ Might Not Be the Best Choice
Regular NAD+ supplements already face challenges in being absorbed due to the molecule's size. Liposomal technology attempts to solve this problem by enhancing bioavailability, but it doesn’t change the fact that NAD+ itself struggles to make it past the digestive system.
Instead, NAD+ precursors like NMN and NR bypass this issue entirely by being water-soluble and effectively absorbed.
For those interested in improving cellular health, NMN in its standard or liposomal form is often the better option. Studies have shown that NMN supplementation reliably raises NAD+ levels and supports energy production, cellular repair, and healthy aging (3).
How Does Liposomal NAD+ Compare to Regular NAD+?
When it comes to NAD+ supplements, liposomal versions are often marketed as being better absorbed. The idea is that the liposomal coating—a protective layer made of fat-based particles—shields the NAD+ molecule, helping it survive the digestive process. But here’s the reality: the molecule size of NAD+ itself makes it tough to absorb, liposomal or not.
The more effective option? Precursors like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside). These are smaller, water-soluble molecules that your body can easily absorb and convert into NAD+.
NMN, for instance, has specific transporters that help it move into cells directly, bypassing the challenges that NAD+ supplements face (4).
Absorption:
Liposomal NAD+: While the coating might help protect NAD+ during digestion, it doesn’t fully address the molecule’s absorption challenges.
NMN and NR: These precursors are absorbed efficiently due to their size and solubility. NMN, in particular, has been shown to reliably raise NAD+ levels in studies (5).
Effectiveness:
Liposomal NAD+: Limited by the inherent challenges of delivering NAD+ directly to cells.
Precursors: NMN and NR are converted into NAD+ in the body, offering more consistent benefits for cellular health and energy production.
Cost:
Liposomal NAD+ supplements are often expensive, but their benefits don’t necessarily justify the price. Precursors like NMN are usually a more effective investment for supporting NAD+ levels.
Top Potential Benefits of NAD+
NAD+ is gaining attention for its potential health benefits, but the science behind these claims is crucial. Let’s dive into some of the evidence-supported advantages of this molecule.
Improved Energy Production
NAD+ plays a central role in cellular energy production by aiding the mitochondria, the powerhouses of your cells.
Research highlights how NAD+ helps convert nutrients into usable energy, which could potentially reduce fatigue and improve overall stamina (6). This connection makes NAD+ a focus for those experiencing energy dips, especially with age.
Enhanced Cellular Repair
NAD+ is involved in DNA repair, helping cells recover from everyday damage caused by stress and environmental factors.
Studies in Nature Communications emphasize its role in activating enzymes called PARPs, which are directly responsible for fixing damaged DNA (7). By maintaining NAD+ levels, you might support your body's ability to stay resilient at a cellular level.
Support for Brain Health
The connection between NAD+ and cognitive function is an exciting area of research. A study found that NAD+ could influence memory and protect against age-related cognitive decline (8).
By supporting energy metabolism in brain cells, NAD+ might help keep mental clarity intact as we age.
Longevity and Healthy Aging
NAD+ activates sirtuins, proteins linked to increased lifespan and healthy aging. Research has shown that sirtuins rely on NAD+ to function properly, helping regulate inflammation and promote cellular resilience (9).
While it’s not a magic solution, maintaining NAD+ levels could contribute to healthier aging over time.
Risks and Side Effects of NAD+ Supplements
NAD+ supplements are generally well tolerated when taken within the recommended dosage. For most people, they offer a promising way to support cellular health with minimal side effects.
However, like anything new you introduce to your body, it’s important to know what to expect. Here’s a closer look at potential risks and side effects:
Mild Digestive Upset: Some individuals report nausea, bloating, or stomach discomfort after taking NAD+ supplements (10).
Flushing or Warm Sensation: High doses of NAD+ may cause a temporary flushing effect, similar to niacin. This is due to vasodilation caused by NAD+-related pathways. While harmless, it might feel uncomfortable for some users (11).
Headaches or Dizziness: Rarely, participants in clinical trials of NAD+ supplements have reported mild headaches or lightheadedness (12).
Potential Allergic Reactions: Allergic reactions, while uncommon, have been reported. These include symptoms like itching, rash, or mild swelling.
Lack of Long-Term Studies: NAD+ research is still in its infancy, and the long-term safety of these supplements is not fully understood.
Given the limited research, it’s best to consult a healthcare professional before starting NAD+ supplements. This ensures you can evaluate the potential benefits against the risks based on your personal health profile.
Who Can Benefit from NAD+ Precursors?
If you’re feeling run down or noticing the effects of aging—like slower recovery or mental fog—NAD+ precursors such as NMN or NR might be worth considering. These supplements are designed to help your body replenish NAD+, which plays a big role in energy production, cellular repair, and brain health.
Fatigue and Energy
As NAD+ levels drop, you might feel your energy levels dip too. Research suggests that maintaining healthy NAD+ levels through precursors like NMN can improve mitochondrial function, which helps cells produce energy more efficiently (13).
Aging and Cognitive Function
NAD+ is key for cellular repair and maintaining brain health. Studies have shown that precursors may support memory and protect against age-related cognitive decline by improving energy metabolism in brain cells (14).
Recovery from Stress
Whether it’s physical stress from a workout or the mental strain of a busy life, NAD+ precursors can help. By fueling cellular repair processes, they may support your body’s ability to bounce back and adapt (15).
NMN + RESVERATROL
Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*
What is the Best Form of NAD+?
If you’re looking to support NAD+ levels, NMN (nicotinamide mononucleotide) is the clear choice. Why? Unlike other forms, NMN bypasses unnecessary conversion steps and uses dedicated transporters to enter cells directly. This makes it one of the most efficient and reliable options for replenishing NAD+.
What About Liposomal NMN?
You may come across liposomal NMN, which markets itself as having enhanced absorption due to a protective liposomal coating. However, NMN is water-soluble and already absorbs efficiently without this extra layer.
While the idea sounds appealing, liposomal technology isn’t necessary for NMN to do its job effectively—it’s a case where simplicity works best.
Studies have shown that NMN may increase NAD+ levels, support mitochondrial function, and improve cellular energy production (16).
These results underline why NMN is a standout option for those looking to maintain cellular health and energy.
How to Take NMN for Best Results
For the best outcomes, take NMN supplements in doses ranging from 300 to 500 mg daily. Morning is ideal, as it aligns with your body’s natural energy cycles. Taking it on an empty stomach can further enhance absorption.
Want to amplify the effects? Pair NMN with Resveratrol, a compound known to activate sirtuins—proteins that rely on NAD+ to support cellular repair and longevity.
Studies suggest this combination creates a powerful synergy, offering more comprehensive support for healthy aging (17).
Can You Get NAD+ from Food?
While you can’t get NAD+ directly from food, certain foods provide precursors like niacin, tryptophan, and riboflavin, which help your body produce it. Chicken, tuna, avocados, and mushrooms are good options.
However, food sources alone may not raise NAD+ levels significantly, especially with aging. Supplementation with NMN or liposomal NAD+ is often more effective, as noted in Cell Metabolism (16).
Best NAD+ Supplements to Try
When choosing an NAD+ supplement, look for options with high bioavailability, like liposomal delivery systems or NMN (nicotinamide mononucleotide). These forms are backed by research and designed to efficiently raise NAD+ levels in your body.
Third-party testing for purity and potency is another key factor to consider. Opt for brands that are transparent about their manufacturing processes and include detailed ingredient sourcing.
Combining NAD+ precursors with Resveratrol can deliver more impactful results. Resveratrol activates sirtuins, which require NAD+ to function optimally. Together, they support energy production, DNA repair, and healthy aging.
A study highlights how this pairing can amplify the benefits of each supplement, making it a popular choice among wellness enthusiasts (17).
One standout option is Omre NMN + Resveratrol. This supplement combines NMN for effective NAD+ replenishment with Resveratrol to maximize sirtuin activation, offering a potent blend for those focused on cellular health and longevity.
Designed for quality and efficacy, it’s a thoughtful choice for anyone serious about maintaining their vitality.
Conclusion
NAD+ is a vital coenzyme that supports energy production, cellular repair, and healthy aging. While direct NAD+ supplementation faces absorption challenges, using precursors like NMN offers a reliable and effective way to replenish NAD+ levels in your body.
These precursors not only fuel cellular processes but also play a significant role in maintaining mental clarity and overall resilience as we age.
For even greater benefits, consider pairing NMN with Resveratrol. This combination supports cellular health by activating sirtuins—proteins linked to longevity and stress resilience.
A well-formulated option like Omre NMN + Resveratrol provides a trusted blend designed to help you maintain energy, support cellular repair, and promote healthy aging.
Interested in elevating your health routine? Check availability and explore how it can support your wellness journey.