Does NAD+ IV Therapy Work? Here's Everything You Need To Know

Does NAD+ IV Therapy Work? 

NAD+ IV therapy does not work as marketed. Research shows NAD+ molecules are too large to be effectively absorbed through IV drips, which limits their ability to boost energy, improve mental clarity, or slow aging. (1)

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in all living cells that play a vital role in energy production, DNA repair, and cellular health. As we age, NAD+ levels decrease, which can impact these essential processes.

NAD+ is like the fuel that keeps our cellular engines running smoothly. It enables critical reactions within cells, helping convert food into energy, repair damaged DNA, and regulate genes related to aging. 

This decline in NAD+ as we age has been linked to various age-related health issues, from reduced energy and slower metabolism to more serious conditions like neurodegenerative diseases.

People are turning to ways to restore NAD+ levels as interest grows in health and longevity. From oral supplements to IV therapies, there are various methods to increase NAD+ in the body, each with its own approach to support the processes that rely on this important molecule.

What is NAD+ IV Therapy?

NAD+ IV therapy involves introducing NAD+ directly into the bloodstream. This method aims to bypass the digestive system and deliver NAD+ to cells, where it is intended to convert into its active form, NADH. NADH is key in energy production, DNA repair, and gene regulation.

While proponents claim that IV administration allows for quicker and more efficient replenishment of NAD+ compared to oral supplements, research suggests otherwise. 

NAD+ is a large molecule, and studies indicate that its absorption and effective utilization within cells may be limited, even when delivered intravenously.

Despite these limitations, NAD+ IV therapy is often marketed as a solution for combating age-related issues like neurodegeneration, metabolic dysfunction, and inflammation. The goal is to support cellular health, reduce inflammation, and enhance overall well-being. 

However, the actual effectiveness of this therapy remains under scrutiny, with more research needed to validate its benefits.

Costs of NAD+ IV Therapy

The cost of NAD+ IV therapy varies widely, typically ranging from $300 to $1,000 per session, depending on the provider, dosage, and location.

Due to the specialized nature of NAD+ administration, this treatment is generally priced higher than other wellness IV therapies. Many clinics recommend multiple sessions for the best results, which can quickly add up, making it a more significant investment. 

Insurance often does not cover NAD+ IV therapy since it's considered experimental, so individuals considering it should prepare for out-of-pocket expenses.

Potential Benefits of NAD+ IV Therapy

NAD+ IV therapy has sparked interest for its potential to support various aspects of health and wellness. While research is ongoing, here are some of the commonly discussed benefits based on early findings and anecdotal evidence.

Could Help Boost Energy Levels

NAD+ plays a key role in mitochondrial function, which is essential for cellular energy production (2). Some people who try NAD+ IV therapy report feeling more energized and less fatigued. 

While the research is still evolving, maintaining NAD+ levels may support better energy metabolism.

May Support Anti-Aging Efforts

NAD+ is often linked to anti-aging due to its role in DNA repair and cellular regeneration. As we age, NAD+ levels naturally decline, which can lead to less efficient cellular processes and increased oxidative stress. 

Early research suggests that replenishing NAD+ may help slow down some age-related changes by promoting healthier cells and improving the body’s ability to repair damage (3). This could potentially result in better skin elasticity, enhanced vitality, and overall improved cellular health. 

Might Improve Cognitive Function

Emerging research highlights NAD+’s role in brain health, particularly in cellular repair and neuron function. 

Some early studies and personal accounts suggest that NAD+ therapy could help with memory and mental clarity, particularly in older adults experiencing cognitive changes (4). 

May Provide Neuroprotective Benefits

There’s growing interest in whether NAD+ can help protect the brain, particularly in conditions like Alzheimer’s and Parkinson’s. 

Although more studies are needed, preliminary research suggests that maintaining NAD+ levels might help reduce neuroinflammation and support overall neuron health (5).

Could Assist in Addiction Recovery

In some addiction recovery programs, NAD+ IV therapy is used to help manage withdrawal symptoms and cravings. 

It might help individuals feel more stable during recovery by potentially aiding in cellular repair and balancing neurotransmitter levels (6). However, further research is necessary to understand its effectiveness fully.

Who Can Benefit from NAD+ IV Therapy?

NAD+ IV therapy is often marketed toward individuals seeking to boost their energy, improve cognitive function, or support overall health. While its effectiveness remains debated, here’s a look at those who might consider it:

• Individuals with chronic fatigue or low energy levels

• Those recovering from substance dependency

• People experiencing age-related cognitive decline

• Individuals interested in anti-aging therapies

• Patients with neurodegenerative conditions

Potential Risks and Side Effects

NAD+ IV therapy comes with certain risks and side effects that potential users should consider.

• Lack of Regulation: NAD+ IV therapy is experimental and not regulated by the FDA, meaning the quality and purity of NAD+ products can vary. This could increase the risk of adverse reactions.

• Allergic Reactions: Some individuals may be allergic to components in the NAD+ IV formulation, potentially leading to reactions like rash, itching, or swelling. It's essential to discuss any known allergies with the provider.

• Drug Interactions: High doses of NAD+ may interact with other medications, potentially impacting the effectiveness of treatments or causing harm. It’s recommended to disclose all medications before therapy.

• Vascular Complications: IV administration carries risks, including infection, vein inflammation (phlebitis), and blood clot formation. Using experienced professionals and sterile techniques helps reduce these risks.

• Unknown Long-term Effects: While NAD+ therapy shows promise, the long-term safety profile is still unknown. Limited research makes it challenging to predict potential effects over time.

• Financial Cost: NAD+ IV therapy can be costly, and insurance often does not cover it due to its experimental nature. This could make it financially burdensome for some individuals.

How Long Do the Effects of NAD+ IV Therapy Last?

The effects of NAD+ IV therapy are often reported to last between 3 to 14 days, depending on individual factors such as health status, dosage, and frequency of treatments.

Some individuals experience immediate benefits, like increased energy and improved focus, which can last for a week or two. 

However, the duration of these effects varies widely based on factors like age, lifestyle, and overall health. Regular sessions are typically recommended to sustain any perceived benefits over time.

How Often Should You Do NAD+ IV Therapy?

Most people begin with 1-2 NAD+ IV therapy sessions per week for 4-6 weeks, followed by maintenance treatments every 4-6 weeks, depending on their health goals.

The frequency of treatments can vary based on individual needs. Those seeking a temporary energy boost may opt for occasional sessions, while individuals managing chronic conditions might require a more consistent schedule. 

Consulting with a healthcare provider is essential to determine the best treatment plan for your specific circumstances.

How Does NAD+ IV Therapy Compare to Other Methods?

When it comes to replenishing NAD+ levels, several methods are available, each with its pros and cons. Let’s break them down.

NAD+ IV Therapy

NAD+ IV therapy introduces NAD+ into the bloodstream, bypassing digestion, but studies suggest it may not be absorbed effectively enough to deliver the promised benefits.

NAD+ IV therapy can be pricey, with each session costing between $300 and $1,000. Many clinics recommend multiple sessions, which can add up quickly. Because it’s considered an experimental treatment, insurance rarely covers it.

Pros:

1. Immediate absorption.

2. Quick onset of effects.

3. Tailored dosages.

4. Suitable for those with severe NAD+ deficiencies.

Cons:

1. High cost.

2. Requires professional administration.

NAD+ Injection

For those seeking a quicker, less expensive alternative, NAD+ injections are another option. These intramuscular shots offer a more direct route into the bloodstream, similar to IV therapy, but the effects might be slightly less intense.

Early studies suggest they can be effective in improving cellular energy and supporting recovery from fatigue or stress (7,8).

NAD+ injections are generally more affordable than IV therapy, typically costing between $100 and $300 per injection. They’re often favored by those who want the benefits of NAD+ without the high price tag of an IV drip.

Pros:

1. Faster administration than IV.

2. Lower cost.

3. Portable option for self-administration (if trained).

4. Suitable for periodic top-ups.

Cons:

1. Can be painful.

2. Limited research compared to IV therapy.

NAD+ Nasal Spray

Nasal sprays offer a non-invasive way to supplement NAD+. They work by allowing NAD+ to be absorbed through the nasal mucosa, potentially bypassing some of the digestive hurdles associated with oral supplements. 

A bottle of NAD+ nasal spray typically costs between $50 and $100, with each bottle lasting a few weeks depending on usage. This makes it a relatively budget-friendly option, though results may take longer than IVs or injections.

Pros:

1. Convenient and non-invasive.

2. Portable and easy to use.

3. Affordable compared to injections or IVs.

4. It can be used daily.

Cons:

1. Inconsistent absorption.

2. Limited studies on long-term efficacy.

NAD+ Oral Supplements

Oral supplements, such as NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside), are widely recognized for their ability to naturally raise NAD+ levels over time. 

Studies support their long-term effectiveness, especially when taken consistently (9). However, since they need to pass through the digestive system, their effects tend to be slower and more gradual than those of other methods.

Oral supplements are the most accessible option, with prices typically ranging from $30 to $80 per month, depending on the brand and dosage. They’re often the go-to choice for individuals looking for an easy, daily solution to maintain NAD+ levels.

Learn more about the best NMN supplements.

Pros:

1. Affordable and accessible.

2. Easy to incorporate into daily routines.

3. Proven efficacy in long-term use.

4. No need for medical supervision.

Cons:

1. Slower absorption.

2. Effects may take longer to notice.

Is NAD+ IV Therapy Worth It?

NAD+ IV therapy is often marketed as a quick fix for boosting energy, improving mental clarity, and slowing the aging process. However, research suggests that NAD+ is a large molecule that doesn’t absorb effectively through IV drips or oral supplements (10). 

Its direct administration offers only short-lived benefits, which leaves many questioning whether the steep price tags are justified for long-term health improvements.

Studies show that precursors like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) are more effective (11,12). These smaller molecules are easily absorbed and converted into NAD+ within the body. 

According to research, NMN and NR help are both able to boost NAD+ levels effectively(13,14). They provide a science-backed, sustainable approach to maintaining energy and vitality.

If you’re serious about supporting your NAD+ levels, Omre NMN + Resveratrol is a good choice. This supplement combines ultra-pure NMN and Resveratrol in research-supported doses with BioPerine® to enhance absorption. It’s a convenient, affordable way to support healthy aging and cellular function.

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Conclusion

NAD+ IV therapy might sound appealing, but the science suggests its benefits are limited. Given that NAD+ is a large molecule that can’t be effectively absorbed through direct administration, focusing on precursors like NMN and Resveratrol is a smarter and more natural approach. 

These compounds provide the building blocks your body needs to maintain optimal NAD+ levels, supporting energy, cognition, and longevity.If you’re ready to take a more sustainable route to cellular health, consider Omre NMN + Resveratrol. It’s a high-purity, research-backed supplement designed to help you age gracefully while supporting your body’s natural energy production.

Check availability.

FAQs

How quickly can I feel the effects of NAD+ IV therapy?

Some individuals report feeling more energized and focused shortly after their first session, while others may notice gradual improvements over a few days (15). However, this may be related to the placebo effect because your cells can’t absorb NAD+. 

Is NAD+ IV therapy safe?

NAD+ IV therapy is generally considered safe when administered by trained professionals. However, as with any IV treatment, there are risks such as vein irritation, infection, or allergic reactions. It’s important to discuss your medical history with a healthcare provider before starting therapy.

Can NAD+ IV therapy help with aging?

NAD+ is often associated with anti-aging because of its role in cellular repair and energy production. While some early research and personal accounts suggest it may support healthier aging, more studies are needed to confirm its long-term effectiveness for anti-aging purposes. On the other hand, NAD+ precursors like NMN and NR have been shown to boost NAD+ levels and improve hallmarks of aging in animal and human studies. 

How long do the benefits of NAD+ IV therapy last?

The effects typically last between 3 to 14 days, depending on your individual health and lifestyle. Regular sessions may help maintain the benefits over time, but it’s best to consult with your healthcare provider to develop a suitable schedule.

Are there alternatives to NAD+ IV therapy?

Yes, alternatives like NMN and NR supplements are available. These precursors are more easily absorbed by the body and converted into NAD+, offering a more practical and cost-effective way to support cellular health.