David Sinclair is most closely associated with NMN, resveratrol, vitamin D, and TMG. He has also discussed metformin, spermidine, fisetin, quercetin, taurine, rapamycin, aspirin, and statins.

That does not mean every item remains part of his daily routine in 2026.

Sinclair has not published a complete, independently verified 2026 supplement list. Much of what appears online comes from his 2019 book Lifespan, earlier interviews, podcast episodes, and discussions about compounds he studies rather than confirmed daily use.

This page separates his best-known personal supplements from older, uncertain, and medically supervised compounds.

Key Takeaways:

• NMN and resveratrol are the supplements most consistently connected with Sinclair’s public routine.

• TMG and vitamin D have also appeared in his public discussions, though exact current doses remain less certain.

• Metformin, statins, and rapamycin are prescription medications, not general longevity supplements.

• Fisetin, quercetin, spermidine, and taurine remain active research topics, but human longevity evidence is limited.

What Supplements Does David Sinclair Take?

Based on his book and public discussions, Sinclair’s most consistently reported supplements include:

• NMN

• Resveratrol

• TMG

• Vitamin D

He has also discussed or reportedly used:

• Vitamin K2

• Spermidine

• Fisetin

• Quercetin

• Taurine

• Fish oil

• Alpha-lipoic acid

• CoQ10

His broader routine has included discussions of metformin, statins, aspirin, and rapamycin. These belong in a separate category because they come with medical risks and may require a prescription.

David Sinclair Supplement Stack at a Glance

These confidence levels describe the quality of the public reporting. They do not measure how effective each compound is.

The Core Supplements Most Closely Linked to Sinclair

1. NMN

NMN, or nicotinamide mononucleotide, is the supplement most strongly linked with David Sinclair.

NMN is a precursor to NAD+, a molecule involved in cellular energy production, DNA maintenance, and many metabolic reactions. Sinclair has publicly described taking around 1 gram in the morning, though that dose is higher than the amount used in several human trials.

A 10-week clinical trial gave 250 mg of NMN per day to 25 postmenopausal women with prediabetes who were overweight or obese. NMN increased muscle NAD+ metabolites and improved muscle insulin sensitivity, but it did not change several broader measures, including body composition and fasting glucose (1).

Another randomized trial gave older men 250 mg daily for six or twelve weeks. Researchers reported increases in NAD-related metabolites and changes in some exploratory measures of muscle function, but the study was small (2).

These findings make NMN interesting. They do not show that NMN slows aging or extends human lifespan.

At Omre, we use 500 mg of 99% pure NMN in our NMN + Resveratrol formula. It is paired with 500 mg of micronized trans-resveratrol and third-party tested for purity, potency, and contaminants.

2. Resveratrol

Resveratrol is another long-standing part of Sinclair’s public routine.

It is a polyphenol found naturally in grapes, berries, peanuts, and red wine. Sinclair has described taking around 1 gram with yogurt or another source of fat.

The reasoning is that resveratrol has low oral bioavailability and is fat soluble. Still, taking it with fat does not settle the larger question of how much reaches human tissues in an active form.

Human findings are mixed. A meta-analysis of 11 randomized trials found no meaningful improvement in glucose control among participants without diabetes, though subgroup results suggested possible benefits among people with diabetes (3).

Later reviews have also reported that effects differ by dose, study population, health status, and outcome measured. Resveratrol should be presented as a researched polyphenol, not a proven human longevity treatment.

3. TMG

TMG stands for trimethylglycine, also known as betaine.

Sinclair has discussed TMG in connection with NMN and methylation. The idea is that the breakdown of excess nicotinamide may use methyl groups, so some people pair NAD+ precursors with a methyl donor.

This remains more of a biochemical rationale than a clinical requirement. Human trials have not established that every person taking NMN needs TMG.

TMG also has its own biological effects. It participates in homocysteine metabolism and supports normal methylation reactions. That does not mean matching NMN and TMG gram for gram is necessary.

4. Vitamin D

Vitamin D has appeared regularly in descriptions of Sinclair’s routine, but exact doses differ across sources.

Vitamin D supports bone health, muscle function, calcium regulation, and immune function. The right intake depends on blood levels, sun exposure, diet, age, skin tone, and medical history.

Rather than copying a public figure’s dose, testing serum 25-hydroxyvitamin D gives a more useful starting point.

5. Vitamin K2

Sinclair has also discussed vitamin K2, commonly paired with vitamin D.

Vitamin K-dependent proteins help regulate calcium use in bones and other tissues. Still, Sinclair’s current form and dose have not been clearly verified.

People taking warfarin or another vitamin K-sensitive anticoagulant should not start K2 without medical advice.

Other Longevity Supplements Sinclair Has Discussed

6. Spermidine

Spermidine is a natural polyamine found in wheat germ, mushrooms, legumes, soy, and aged cheese.

It is studied mainly for its connection with autophagy, the process cells use to break down and reuse damaged components.

A 12-month randomized trial tested a spermidine-rich extract in 100 older adults with subjective cognitive decline. The supplement was well tolerated, but it did not produce a significant improvement in the primary memory outcome compared with placebo (4).

This is an important reality check. Spermidine has compelling laboratory research, but human benefits remain less clear.

Sinclair has discussed taking spermidine. However, online claims about his exact dose are inconsistent, partly because some pages confuse the amount of wheat germ extract with the amount of active spermidine.

7. Fisetin

Fisetin is a flavonoid found in strawberries, apples, persimmons, and onions.

Researchers study it as a possible senolytic, meaning a compound that may help remove certain senescent cells. A widely cited study found that fisetin reduced markers of cellular senescence and improved lifespan or health measures in mice. The study also tested human tissue samples, but it was not proof of longer life in people (5).

Human fisetin research has started to grow, but it remains early. Sinclair has discussed fisetin in longevity conversations, yet his exact current dose and schedule are not firmly documented.

8. Quercetin

Quercetin is another plant flavonoid studied for antioxidant, metabolic, and senolytic effects.

It appears in older summaries of Sinclair’s stack, but its place in his current routine is unclear. Research also frequently combines quercetin with dasatinib, a prescription medicine, making it hard to apply those results to quercetin supplements alone.

9. Taurine

Taurine is an amino sulfonic acid involved in bile formation, electrolyte balance, muscle function, and cellular signaling.

Interest grew after a 2023 study reported that taurine concentrations declined with age in several species. Supplementation improved health measures and lifespan in mice, while some human data showed associations between taurine levels, exercise, and metabolic health (6).

The study did not prove that taurine supplements extend human lifespan.

Sinclair has reportedly discussed taking around 2 grams daily, though this should be viewed as a personal practice rather than a research-backed anti-aging dose.

10. Fish Oil, Alpha-Lipoic Acid, and CoQ10

Fish oil, alpha-lipoic acid, and CoQ10 appear in some older descriptions of Sinclair’s routine.

Current details are less clear:

• Fish oil provides EPA and DHA, which support normal cardiovascular and brain function.

• Alpha-lipoic acid participates in mitochondrial energy metabolism.

• CoQ10 supports mitochondrial energy production and is sometimes discussed alongside statin use.

These compounds should not be presented as confirmed parts of Sinclair’s daily 2026 stack without a newer first-hand statement.

Prescription and Medical Compounds

11. Metformin

Metformin is prescribed mainly for type 2 diabetes. Sinclair has publicly discussed taking it because of his interest in metabolic and aging pathways.

It is not a general wellness supplement.

Research in healthy older adults has raised questions about combining metformin with exercise. In one randomized trial, metformin reduced some improvements in cardiorespiratory fitness and skeletal muscle mitochondrial adaptation during a 12-week aerobic exercise program (7).

Another trial found that metformin reduced the average gain in muscle size during progressive resistance training in older adults (8).

These results do not mean everyone using metformin should stop exercising or stop treatment. They show why prescription decisions need personal medical supervision.

12. Statins

Sinclair has discussed statin use in the context of his family history and cholesterol.

That context is easy to lose when online articles copy his stack. Statins are prescribed based on factors such as LDL cholesterol, cardiovascular history, age, diabetes, blood pressure, and calculated risk.

A statin is not a general anti-aging supplement.

13. Low-Dose Aspirin

Earlier accounts reported that Sinclair used low-dose aspirin.

Recommendations around aspirin for primary cardiovascular prevention have become more cautious because the potential benefit must be weighed against bleeding risk. Readers should not add aspirin to a longevity routine without medical advice.

14. Rapamycin

Rapamycin affects mTOR, a pathway involved in growth, nutrient sensing, immunity, and cellular maintenance.

It has extended lifespan in several animal models, making it a major topic in aging research. Human longevity use remains experimental, and rapamycin can affect immune function, blood lipids, wound healing, and glucose control.

Sinclair has discussed rapamycin research. That is not the same as publishing a confirmed personal dose or recommending it for healthy people.

Does David Sinclair Endorse a Supplement Brand?

David Sinclair has not publicly endorsed Omre or announced one official brand for his complete supplement routine.

Many pages attach product recommendations to his name. Those recommendations come from the publisher, not necessarily from Sinclair.

A better way to compare products is to look at:

• The exact dose of each active ingredient

• Ingredient purity

• Third-party testing

• Contaminant testing

• Manufacturing standards

• Added fillers and allergens

• Clear certificates of analysis

Avoid any product implying that Sinclair takes or endorses it without direct proof.

What the Human Evidence Really Shows

The evidence behind Sinclair’s stack is uneven.

NMN has several short human trials showing that it can raise NAD-related metabolites. Some studies have also found changes in insulin sensitivity or physical performance measures in selected groups.

Resveratrol has a larger research base, but results remain inconsistent.

Spermidine has been tested in older adults, though a major 12-month trial did not meet its primary cognitive outcome.

Fisetin and taurine have strong animal interest, but little direct proof for human longevity.

No supplement in this list has been shown to reverse human aging or extend human lifespan.

A useful way to judge any longevity claim is to ask:

1. Was the study conducted in humans?

2. How many people participated?

3. How long did it last?

4. What dose was tested?

5. Did it measure a health outcome or only a biomarker?

6. Has another research group reproduced the result?

A change in NAD+, autophagy markers, or biological-age estimates can be interesting. It is not the same as proving fewer diseases or a longer life.

Sinclair’s Lifestyle Matters More Than the Stack

Supplements receive the headlines, but Sinclair also discusses meal timing, exercise, sleep, blood testing, glucose management, and a largely plant-focused diet.

That context matters.

Exercise has far more human outcome data than experimental longevity supplements. Blood-pressure control, avoiding smoking, maintaining muscle, managing cholesterol, sleeping well, and eating a nutrient-rich diet also carry stronger evidence.

A supplement stack cannot make up for weak fundamentals. It is more like the trim on a house, not the foundation.

Should You Copy David Sinclair’s Supplement Routine?

No. His routine reflects his own health history, laboratory testing, risk factors, and interpretation of early aging research.

Copying it creates several problems:

• Some reported items may no longer be current.

• Several doses come from older interviews.

• Prescription medicines require personal risk assessment.

• Supplements may interact with medications.

• Animal findings may not apply to humans.

• More is not always better.

A safer approach is to identify the goal behind each item. Someone with low vitamin D needs a different plan from someone interested in NAD+ metabolism or managing high cholesterol.

Speak with a qualified healthcare professional before combining several supplements or using them alongside prescription medicine.

Final Words

David Sinclair’s best-known supplement routine centers on NMN and resveratrol, with TMG and vitamin D also appearing in public discussions.

The rest of the list is less tidy. Some compounds come from older mentions, some reflect research interests, and others are prescription medications linked to his personal medical context.

At Omre, we do not claim that David Sinclair takes or endorses our products. We use the human research as a starting point, then formulate with transparent doses and third-party testing.

Our NMN + Resveratrol formula contains 500 mg of NMN, 500 mg of micronized trans-resveratrol, and 5 mg of BioPerine^® per serving for adults seeking research-informed NAD+ and healthy-aging support.

FAQs

What supplements does David Sinclair take every day?

NMN and resveratrol are the most consistently reported parts of his routine. TMG and vitamin D have also appeared in public discussions. Sinclair has not published a complete, verified daily list for 2026.

How much NMN does David Sinclair take?

Sinclair has publicly discussed taking around 1 gram of NMN daily. Several human clinical trials have used lower amounts, including 250 mg per day.

Does David Sinclair still take metformin?

He has discussed taking metformin in the past, but his exact current schedule is not independently verified. Metformin is a prescription medication and should not be copied for longevity purposes.

Does David Sinclair take NMN or NR?

Sinclair is more closely associated with NMN. He has discussed both NMN and nicotinamide riboside as NAD+ precursors, but NMN appears more consistently in accounts of his personal routine.

Does David Sinclair recommend a specific supplement brand?

He has not released one official brand list for his complete stack. Product recommendations appearing on third-party pages should not be treated as personal endorsements.

Are David Sinclair’s supplements proven to reverse aging?

No. Some compounds affect pathways linked with aging or have changed biomarkers in short studies, but none have been proven to reverse aging or extend lifespan in humans.

References

1. Yoshino M, et al. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021.

2. Igarashi M, et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging. 2022.

3. Liu K, et al. Effect of resveratrol on glucose control and insulin sensitivity: A meta-analysis of 11 randomized controlled trials. American Journal of Clinical Nutrition. 2014. 

4. Wirth M, et al. Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline: A randomized clinical trial. JAMA Network Open. 2022. 

5. Yousefzadeh MJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018.

6. Singh P, et al. Taurine deficiency as a driver of aging. Science. 2023.

7. Konopka AR, et al. Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell. 2019. 

8. Walton RG, et al. Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults. Aging Cell. 2019.