7 Best Resveratrol Supplements in 2025 for Longevity, Energy & Heart Health

Best Resveratrol Supplements at a Glance

What is the Best Resveratrol Supplement?

Here are some of the best resveratrol supplements in 2025:

• Best Overall Resveratrol Supplement: Omre NMN + Resveratrol

• Best Resveratrol for Absorption: Renue by Science LIPO Trans-Resveratrol

• Best Budget Resveratrol Supplement: Nutricost Resveratrol 700mg

• Best High-Dose Resveratrol: ProHealth Longevity Trans-Resveratrol Plus

• Best Pure Resveratrol with No Fillers: Toniiq Ultra High Purity Resveratrol

• Best Resveratrol for Skin and Anti-Aging: Reserveage Resveratrol Beauty 500mg

• Best Resveratrol with Natural Ingredients: Garden of Life Raw Resveratrol

1. Best Overall Resveratrol Supplement: Omre NMN + Resveratrol

If you’re looking for more than just basic antioxidant support, Omre NMN + Resveratrol is one of the most complete options available. 

Unlike standard resveratrol supplements, this one also includes 500mg of NMN, a direct NAD+ precursor that helps your cells produce energy and repair themselves. That makes it a strong choice for anyone focused on aging, fatigue, or long-term wellness.

Each serving also includes 500mg of micronized trans-resveratrol, the most absorbable form, plus BioPerine® (black pepper extract) to improve absorption. 

All ingredients are carefully dosed to match what’s been used in human clinical studies, which is a big plus for people who want results backed by science.

This formula was developed by doctors and is third-party tested, so you know exactly what you're getting. It’s priced at $59.97 for a 30-day supply, or about $1.99 per day, with 10% savings if you subscribe. 

While it’s on the higher end cost-wise, the quality and formulation make it worth it if you’re serious about healthy aging.

If you’re looking for one supplement that supports your energy, brain function, and longevity at the same time, this is it. NMN and resveratrol work hand in hand, making this combo a smart investment for long-term cellular health.

Pros:

• Combines NMN and resveratrol for enhanced cellular energy and longevity support

• Uses micronized trans-resveratrol for better absorption

• Includes BioPerine® to improve bioavailability

• Doctor-developed and third-party tested

Cons:

• Higher price point compared to basic resveratrol supplements

• Only available through limited online stores

Shop now

2. Best Resveratrol for Absorption: Renue by Science LIPO Trans-Resveratrol

If you're looking for a resveratrol supplement that absorbs better than most, Renue by Science LIPO Trans-Resveratrol is a top choice.

It uses a liposomal delivery system, which helps protect the resveratrol as it passes through your digestive system, making it easier for your body to absorb.

Each capsule contains 125mg of trans-resveratrol, which may sound low compared to others, but thanks to the liposomal technology, it's likely more effective than higher doses in standard capsules. 

This form is ideal for people who want a lower daily dose but still care about bioavailability.

You get 90 capsules for $41.95, which breaks down to about $0.47 per capsule. There’s also a 10% discount available with a subscription. 

The formula is vegan, non-GMO, and free from unnecessary fillers, making it a clean and trustworthy option for daily use.

If you're someone who prefers quality over quantity and wants the most out of each capsule, this is a strong pick backed by thoughtful formulation and third-party testing.

Pros:

• Liposomal delivery enhances absorption significantly

• Clean formula with no unnecessary additives

• Vegan, non-GMO, and third-party tested

• Economical per capsule with 90-count supply

Cons:

• Lower resveratrol dose per capsule

• No added ingredients for broader antioxidant support

Shop now

3. Best Budget Resveratrol Supplement: Nutricost Resveratrol 700mg

If you're on a tight budget but still want a good-quality resveratrol supplement, Nutricost Resveratrol 700mg offers one of the most affordable options available.

Each serving gives you a solid 700mg of resveratrol sourced from Japanese knotweed, a common plant used for this ingredient.

You get 120 capsules per bottle, which covers 60 servings, all for about $21.95—that’s just $0.36 per serving. Despite the low price, the supplement is non-GMO, gluten-free, and made in a GMP-compliant facility in the USA.

This is a straightforward, no-frills supplement. There are no added ingredients for absorption or extra antioxidant blends, so it’s ideal if you just want pure resveratrol at a generous dose.

For anyone new to resveratrol or trying it long term without spending too much, Nutricost is a great entry point.

Pros:

• Affordable price for high-potency resveratrol

• Non-GMO and gluten-free

• Made in a GMP-certified facility in the USA

• Great option for long-term use on a budget

Cons:

• No absorption enhancers like BioPerine®

• Basic formula with no added nutrients or antioxidants

Shop now

4. Best High-Dose Resveratrol: ProHealth Longevity Trans-Resveratrol Plus

ProHealth Longevity Trans-Resveratrol Plus is one of the highest-dose supplements on this list, offering 1,000mg of 99.5% pure trans-resveratrol per serving.

But what makes it stand out even more is the extra antioxidant blend—you also get quercetin, green tea extract, red wine extract, and BioPerine® for better absorption.

This is a solid pick if you’re looking for something comprehensive that covers more than just resveratrol. It supports cellular repair, heart health, and inflammation reduction in a well-rounded way.

Each bottle provides 60 capsules (30 servings) and costs around $29.53, or about $0.98 per serving. That’s quite reasonable for the high potency and extra ingredients included.

If you’re looking for a powerful, all-in-one antioxidant supplement to support aging, energy, and immunity, this formula has a lot going for it.

Pros:

• High 1000mg dose of trans-resveratrol per serving

• Includes a blend of synergistic antioxidants like quercetin and green tea extract

• Contains BioPerine® for better absorption

• Competitive price for a comprehensive formula

Cons:

• May be too strong for beginners or sensitive stomachs

• Capsule size could be large for some users

Shop now

5. Best Pure Resveratrol with No Fillers: Toniiq Ultra High Purity Resveratrol

If purity is your top priority, Toniiq Ultra High Purity Resveratrol delivers. Each capsule contains 600mg of resveratrol, made with 98% pure trans-resveratrol sourced from polygonum cuspidatum (Japanese knotweed). That level of purity is rare at this price point.

This product is made without fillers, artificial ingredients, or preservatives. It’s also tested by a third-party lab for purity and quality, so you can feel confident about what you're putting in your body.

You get 60 capsules per bottle for $25.97, and you can save 15% with a subscription. That breaks down to about $0.43 per serving, making it both clean and cost-effective.

Toniiq is a great option if you want a high-quality resveratrol supplement with a minimal ingredient list and strong purity standards.

Pros:

• 98% pure trans-resveratrol from Japanese knotweed

• No fillers, artificial additives, or preservatives

• Third-party tested for quality and safety

• Excellent value for a premium-level purity

Cons:

• No added ingredients to support absorption

• May not suit those looking for multi-functional blends

Shop now

6. Best Resveratrol for Skin and Anti-Aging: Reserveage Resveratrol Beauty 500mg

Reserveage Resveratrol Beauty is designed for people who want to support both cellular health and skin aging. It contains 500mg of trans-resveratrol, sourced from Japanese knotweed and red wine grapes, along with added beauty-supporting ingredients like quercetin.

The blend is marketed as “Pro-Longevity Factors®” and may help protect skin from environmental stress while also supporting antioxidant defenses and overall vitality.

Each bottle contains 60 capsules (60 servings) and costs $62.95, or about $1.05 per serving. It’s a bit more expensive than most others, but it targets two goals at once: inner wellness and outer radiance.

If you're specifically looking for a resveratrol supplement with beauty and anti-aging in mind, this one’s built for you.

Pros:

• Includes beauty-focused antioxidants like quercetin

• Targets both skin health and cellular wellness

• Made with high-quality grape-derived resveratrol

• Non-GMO and gluten-free

Cons:

• Higher price per serving

• Focused more on beauty, may not appeal to all users

Shop now

7. Best Resveratrol with Natural Ingredients: Garden of Life Raw Resveratrol

For those who prefer whole-food supplements, Garden of Life Raw Resveratrol offers a unique, food-based formula.

Each capsule includes a raw resveratrol blend (578mg) with 350mg active trans-resveratrol, plus 25mg of organic antioxidants from fruits and veggies, and 500 million CFU of probiotics.

It’s one of the only options that combines resveratrol with gut health support and natural antioxidants from things like apple, grape, spinach, kale, and blueberry.

You get 60 capsules (60 servings) for around $37.70, or $0.63 per serving. That’s a fair price for a supplement that supports more than just one area of health.

If you’re someone who prefers natural, whole-food-based nutrition with added gut and antioxidant support, this is a strong and well-rounded choice.

Pros:

• Includes raw whole-food-based antioxidants and probiotics

• 350mg active trans-resveratrol plus added fruit and vegetable extracts

• Supports gut and immune health in addition to antioxidant defense

• Certified organic and non-GMO

Cons:

• Lower resveratrol content compared to some competitors

• May not be ideal for those who prefer isolated, high-dose resveratrol

Shop now

How We Tested the Supplements

We reviewed over a dozen resveratrol supplements on the market and narrowed it down to seven based on quality, effectiveness, and user trust. 

Our selection process included carefully analyzing the ingredients, dosages, and how each product delivers resveratrol—whether through liposomal tech, trans-resveratrol form, or added compounds like NMN and BioPerine.

We looked at third-party testing, brand transparency, and certifications like non-GMO and gluten-free. We also cross-checked ingredient purity and the presence of known absorption enhancers. 

Beyond labels, we read through hundreds of customer reviews on Amazon, official websites, and health forums to understand real-world results, side effects, and user satisfaction.

We prioritized products that were backed by clinical research or matched doses commonly used in studies. All this helped us confidently recommend the best resveratrol supplements for different goals like heart health, skin support, and longevity.

What is Resveratrol?

Resveratrol is a natural antioxidant found in red grapes, berries, and peanuts that may support healthy aging, heart health, and cellular protection. It belongs to a group of plant compounds called polyphenols, which act like antioxidants in the body.

It's most famously found in red wine, but you'd have to drink a lot to get the amount used in studies, so supplements have become a popular alternative. 

Many researchers believe resveratrol works by fighting oxidative stress and activating specific proteins in your body, like sirtuins, which play a role in aging and inflammation.

Resveratrol is often studied for its potential to support blood flow, reduce inflammation, and protect brain cells. While more human studies are still needed, early evidence from lab and animal research is encouraging. 

Supplements that use trans-resveratrol or micronized forms may help improve how well your body absorbs it.

How Resveratrol Works

Resveratrol supports your body by acting as a powerful antioxidant and inflammation modulator. It’s found naturally in red grapes, berries, peanuts, and Japanese knotweed, but supplements provide a much higher concentration. 

One of its key roles is reducing oxidative stress, an imbalance that damages cells and speeds up aging. At the cellular level, resveratrol activates a group of proteins called sirtuins, especially SIRT1. 

These proteins help regulate how your cells respond to stress, repair DNA, and manage energy. 

Researchers believe this is part of how resveratrol may support healthy aging, metabolism, and even longevity. In fact, some animal studies have shown resveratrol can mimic the effects of calorie restriction, which has been linked to a longer lifespan.

Resveratrol may also support heart and brain health by increasing nitric oxide production, which improves blood flow and helps keep blood pressure in check. 

It’s been studied for its role in protecting blood vessels, lowering LDL oxidation, and improving insulin sensitivity in people with metabolic issues. One clinical trial found that postmenopausal women taking resveratrol saw a 33% improvement in cognitive performance over six months.

Because resveratrol is hard to absorb, many supplements now use trans-resveratrol, micronized forms, or liposomal delivery systems to help your body use it more effectively. 

You’ll also see it combined with BioPerine® (black pepper extract) or paired with NMN or quercetin for added cellular and metabolic support.

If you’re looking for a supplement that targets inflammation, aging, brain function, or cardiovascular support, resveratrol is one of the most promising options backed by early but growing research.

What are the Benefits of Resveratrol?

Resveratrol is widely researched for its antioxidant and anti-inflammatory properties. While many studies are still early-stage or animal-based, here are some potential health benefits supported by scientific research:

• May support healthy blood pressure: Studies suggest resveratrol may increase nitric oxide production, helping blood vessels relax and improving systolic blood pressure in some individuals (1).

• Can improve cholesterol and blood fats: Animal studies show resveratrol may raise “good” HDL and lower oxidized LDL, which is linked to plaque buildup in arteries (2).

• May support healthy blood sugar and insulin sensitivity: Animal research suggests resveratrol may help the body respond better to insulin and reduce oxidative stress related to diabetes (3).

• Shows promise in brain health and memory: Research links resveratrol to slower age-related cognitive decline by protecting brain cells and interfering with beta-amyloid buildup (4).

• May reduce joint pain: In animal studies, resveratrol helped protect cartilage from breakdown and reduce inflammation in arthritic joints (5).

• May extend lifespan (in animals): In studies on worms, fish, and mice, resveratrol has been shown to activate longevity genes and mimic some effects of calorie restriction (6).

• Could have anti-cancer potential: Lab studies suggest resveratrol may interfere with cancer cell growth, gene expression, and hormone activity, though more human trials are needed (7).

How to Choose the Best Resveratrol Supplement

There are many resveratrol supplements on the market, but not all of them offer the same quality or benefits. Here are the key things to look for when choosing the best resveratrol supplement for your needs:

Purity and Form of Resveratrol

Look for supplements that use trans-resveratrol, the most bioavailable and researched form. Some brands also use micronized or liposomal versions to improve absorption. 

Higher purity—usually 98% or more—means you're getting a concentrated and effective product without unnecessary fillers.

Absorption and Delivery Method

The body does not easily absorb resveratrol, so products that include absorption enhancers, such as BioPerine (black pepper extract) or use liposomal technology, are often more effective. These methods help your body make better use of the supplement.

Dosage Per Serving

The ideal daily dose can vary, but many studies use between 250mg and 1000mg per day. Consider your health goals and tolerance level. 

Start with a moderate dose if you're new, and consult your doctor if you're unsure.

Added Ingredients for Synergy

Some supplements combine resveratrol with NMN, NR, quercetin, or antioxidants to offer broader cellular support. These blends may be helpful if you're looking for overall longevity, energy, or anti-aging benefits.

Brand Reputation and Testing

Choose brands that are transparent about their sourcing and use third-party testing to verify quality and safety. Certifications like non-GMO, vegan, or GMP-compliant manufacturing also add to a brand’s trustworthiness.

Trans-Resveratrol vs. Cis-Resveratrol

Trans-resveratrol is the most active and bioavailable form of resveratrol, while cis-resveratrol is less stable and not as well studied for health benefits. Most high-quality supplements use trans-resveratrol because it's the form linked to positive results in research on aging, inflammation, and heart health.

Chemically, both forms are isomers, meaning they have the same molecular structure but are arranged differently. 

Trans-resveratrol maintains its shape better under light and heat, making it more stable and effective in the body. 

Cis-resveratrol, on the other hand, can form when trans-resveratrol breaks down, but it doesn’t activate sirtuins or support antioxidant pathways as effectively.

If you're choosing a supplement, check the label for "trans-resveratrol" and a listed purity percentage, typically 98% or higher. 

This ensures you're getting the version backed by science, especially if you're aiming for benefits like improved blood flow, cognitive support, or anti-aging effects.

Who Should Take Resveratrol?

Resveratrol may be a good option for adults looking to support healthy aging, heart health, brain function, or inflammation control. It’s especially popular among people over 40, those with high stress levels, or anyone interested in maintaining energy and cellular health as they age.

This natural compound is often used by individuals aiming to protect their cells from oxidative damage, improve blood flow, or manage blood sugar and cholesterol levels. 

It’s also a common choice for people interested in longevity, particularly when combined with NMN or other NAD+ boosters. 

Some early research also points to benefits for postmenopausal women, those with joint discomfort, and individuals looking to support memory and cognitive clarity.

If you're dealing with fatigue, brain fog, or signs of early aging, or you’re simply proactive about long-term wellness, resveratrol might fit well into your daily routine. 

Just be sure to talk to your doctor if you take medication, especially blood thinners or diabetes treatments.

Are Resveratrol Supplements Safe?

Yes, resveratrol supplements are generally considered safe for most healthy adults when taken at moderate doses. Side effects are usually mild and uncommon, especially when following the recommended serving size on the label.

That said, high doses, especially above 1000mg per day, may cause digestive issues like nausea or diarrhea in some people. It may also interact with certain medications, particularly blood thinners, because resveratrol can affect how blood clots.

If you're pregnant, breastfeeding, or taking prescription medication, it’s best to speak with your doctor before starting any new supplement. 

Like many antioxidants, resveratrol works best as part of a balanced lifestyle rather than a cure-all solution.

Resveratrol-Rich Foods and Beverages

While supplements provide a concentrated dose, you can also get small amounts of resveratrol through certain foods and drinks:

• Red grapes (especially the skins)

• Red wine

• Blueberries

• Cranberries

• Peanuts

• Dark chocolate

• Cocoa powder

• Japanese knotweed (used in many supplements)

These foods can complement your supplement routine and support your antioxidant intake naturally.

Alternatives to Resveratrol Supplements

If resveratrol isn’t the right fit for you or you’re looking to support healthy aging in other ways, there are several well-researched alternatives worth considering:

• NMN (Nicotinamide Mononucleotide): A direct precursor to NAD+, supports cellular energy, metabolism, and DNA repair. Often paired with resveratrol for added effect.

• Curcumin: The active compound in turmeric, known for its anti-inflammatory and antioxidant properties. Works well with black pepper extract for better absorption.

• Quercetin: A natural flavonoid found in onions and apples that may support immune health, reduce inflammation, and clear out senescent (aging) cells.

• Omega-3 Fatty Acids: Found in fish oil and flaxseed, these help reduce inflammation and support brain and heart health.

• CoQ10 (Ubiquinol): Supports mitochondrial energy production and cardiovascular function, especially helpful for older adults or those on statins.

Conclusion

Resveratrol is one of the most promising natural compounds for healthy aging, heart health, and cellular support. While research is still ongoing, current studies show encouraging results, especially when it's taken in the right form and dosage.

The best resveratrol supplement for you depends on your needs and budget. From high-purity capsules to powerful blends with NMN, there’s a quality option for everyone.

If you're looking for an advanced formula that supports energy, NAD+ levels, and healthy aging in one supplement, Omre NMN + Resveratrol is our top recommendation.

It combines two of the most effective ingredients in one convenient dose. Check availability to see if it’s in stock today.

FAQs

What is the best form of resveratrol to take?

The most effective form is trans-resveratrol, especially when it’s micronized or delivered in a liposomal form to improve absorption. Look for supplements that also include absorption enhancers like BioPerine®.

Can I take resveratrol every day?

Yes, daily use is generally safe and common. Most people take between 250mg to 500mg per day, but it's always good to start low and see how your body responds.

What time of day should I take resveratrol?

There’s no strict rule, but many people take it in the morning with food or healthy fat to help with absorption. Some prefer pairing it with other supplements like NMN or quercetin for better synergy.

Are there any side effects of resveratrol?

Most people tolerate resveratrol well. Mild side effects may include stomach upset or headache, especially at high doses. Taking it with food may help reduce discomfort.

Is resveratrol better with NMN or NR?

Both NMN and NR are NAD+ precursors that pair well with resveratrol. However, many experts and studies currently favor NMN for its direct role in NAD+ production. Combining it with resveratrol may offer stronger support for energy and cellular health.