7 Best Resveratrol Supplements in 2025 for Longevity, Energy & Heart Health

Top Resveratrol Supplements at a Glance

Here’s a quick comparison of the top resveratrol picks so you can see how they stack up side by side.

Best Resveratrol Supplement: Our Top Picks

• Best Overall Resveratrol Supplement: Omre NMN + Resveratrol

• Best Resveratrol for Absorption: Renue by Science LIPO Trans-Resveratrol

• Best Budget Resveratrol Supplement: Nutricost Resveratrol 700mg

• Best High-Dose Resveratrol: ProHealth Longevity Trans-Resveratrol Plus

• Best Pure Resveratrol with No Fillers: Toniiq Ultra High Purity Resveratrol

• Best Resveratrol for Skin and Anti-Aging: Reserveage Resveratrol Beauty 500mg

• Best Resveratrol with Natural Ingredients: Garden of Life Raw Resveratrol

1. Best Overall Resveratrol Supplement: Omre NMN + Resveratrol

At Omre, we wanted to go beyond basic antioxidant support, so we created a formula that brings together two of the most researched ingredients for healthy aging.

Each serving combines 500 mg of NMN, a direct NAD+ precursor that supports cellular repair and energy production, with 500 mg of micronized trans-resveratrol for better absorption. Together, they act like a power duo for those who want to stay energized, age well, and protect long-term vitality.

To make the nutrients even more effective, we added BioPerine® (black pepper extract), which improves bioavailability. The dosages mirror amounts used in human clinical studies, something that’s still rare in supplements.

Doctor-developed and third-party tested, Omre NMN + Resveratrol is made for people who want confidence in what they’re taking every day.

Pricing is $59.97 for 30 servings (about $1.99 per day), with subscription savings available. 

While it costs more than a standard resveratrol capsule, the science-backed pairing of NMN and resveratrol makes it one of the smartest choices for energy, brain health, and longevity.

Key Benefits

• NMN + Resveratrol combination for stronger cellular support

• Micronized trans-resveratrol for higher absorption

• BioPerine® to improve nutrient uptake

• Doctor-formulated and third-party tested

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2. Best Resveratrol for Absorption: Renue by Science LIPO Trans-Resveratrol

When absorption matters most, Renue by Science LIPO Trans-Resveratrol stands out. It uses a liposomal delivery system that shields resveratrol as it passes through digestion, giving your cells a better chance to use it. 

Each capsule contains 125 mg of trans-resveratrol, which might sound modest compared to others, but liposomal forms are often more effective than higher-dose standard capsules.

This makes it a smart choice for people who want a steady, efficient dose without loading their system. The formula is vegan, non-GMO, and filler-free, with third-party testing for purity. A 90-capsule bottle costs $41.95 (about $0.47 per capsule), with subscription discounts available.

If you value quality delivery over sheer milligrams, this clean and well-designed formula deserves attention.

Key Benefits:

• Liposomal delivery system significantly improves absorption

• Free from unnecessary additives

• Vegan, non-GMO, and third-party tested

• Affordable per capsule with 90-count supply

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3. Best Budget Resveratrol Supplement: Nutricost Resveratrol 700mg

For those who want resveratrol without stretching their budget, Nutricost Resveratrol 700 mg is a dependable pick.

Each serving provides a generous 700 mg sourced from Japanese knotweed, a well-studied plant source for this compound. You get 120 capsules per bottle (60 servings) for just $21.95, which works out to about $0.36 per serving. 

Despite the low price, it’s non-GMO, gluten-free, and manufactured in a GMP-compliant facility in the USA.

This is a straightforward formula: no fancy delivery systems, no added blends. Just pure resveratrol in a solid dose, making it an excellent entry point for beginners or long-term users who want something affordable and reliable.

Key Benefits:

• High dose at an accessible price

• Non-GMO and gluten-free

• Made in a GMP-certified facility in the USA

• Good option for long-term use on a budget

• No additional supportive nutrients or antioxidants

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4. Best High-Dose Resveratrol: ProHealth Longevity Trans-Resveratrol Plus

If you’re aiming for maximum potency, ProHealth Longevity Trans-Resveratrol Plus is hard to overlook.

Each serving packs 1,000 mg of 99.5% pure trans-resveratrol, making it one of the strongest on the market. But potency isn’t its only strength. 

This formula also adds quercetin, green tea extract, red wine extract, and BioPerine® to round out antioxidant support and improve absorption.

At about $29.53 for 30 servings (around $0.98 per serving), it’s competitively priced considering the strength and synergy of the ingredients. This makes it ideal for people looking for comprehensive antioxidant coverage, not just resveratrol alone.

For those ready for a powerful, multi-ingredient formula to support heart health, cellular repair, and immunity, this supplement delivers.

Key Benefits:

• High 1000 mg dose of pure trans-resveratrol

• Includes synergistic antioxidants like quercetin and green tea extract

• Contains BioPerine® for improved absorption

• Strong value for the dosage and blend

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5. Best Pure Resveratrol with No Fillers: Toniiq Ultra High Purity Resveratrol

If purity tops your list, Toniiq Ultra High Purity Resveratrol is hard to beat. Each capsule delivers 600 mg of resveratrol standardized to 98% pure trans-resveratrol, sourced from Japanese knotweed (Polygonum cuspidatum). 

That level of concentration is uncommon, especially at this price.

The formula contains no fillers, artificial ingredients, or preservatives. Every batch is tested by an independent lab for quality and safety, giving you peace of mind about what you’re taking daily.

A 60-capsule bottle costs $25.97, or about $0.43 per serving, with subscription savings available. For anyone who wants a clean, potent resveratrol supplement with a minimal ingredient list, Toniiq delivers strong value.

Key Benefits:

• 98% pure trans-resveratrol from Japanese knotweed

• No fillers, additives, or preservatives

• Third-party tested for safety and quality

• Excellent value for premium purity

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6. Best Resveratrol for Skin and Anti-Aging: Reserveage Resveratrol Beauty 500mg

Reserveage Resveratrol Beauty is designed for people who care about both cellular health and skin vitality. 

Each serving provides 500 mg of trans-resveratrol from Japanese knotweed and red wine grapes, paired with quercetin and other antioxidants under the brand’s “Pro-Longevity Factors®” blend.

This combination targets oxidative stress linked to visible aging while also supporting energy and overall wellness. In other words, it aims to help you feel younger on the inside while looking fresher on the outside.

One bottle offers 60 servings for $62.95, or about $1.05 per serving. It’s pricier than many competitors, but it’s tailored to those who want beauty-focused support in addition to the usual longevity benefits.

Key Benefits:

• Includes quercetin and beauty-focused antioxidants

• Supports skin radiance and cellular health together

• Made with grape-derived resveratrol

• Non-GMO and gluten-free

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7. Best Resveratrol with Natural Ingredients: Garden of Life Raw Resveratrol

For those who prefer a whole-food approach, Garden of Life Raw Resveratrol is a standout option. Each serving contains a 578 mg raw blend with 350 mg active trans-resveratrol, plus 25 mg of antioxidant extracts from fruits and vegetables. 

To round it out, the formula includes 500 million CFU of probiotics for gut and immune support.

Ingredients come from organic sources like apple, grape, kale, spinach, and blueberry, making this one of the few resveratrol supplements that combine antioxidant defense with digestive health.

A 60-serving bottle costs about $37.70, or $0.63 per serving, which is reasonable given the added whole-food nutrition and probiotics. If you want more than just a single-ingredient capsule, this product delivers a well-rounded, natural option.

Key Benefits:

• Includes whole-food antioxidants and probiotics

• 350 mg trans-resveratrol plus fruit and vegetable extracts

• Supports gut, immune, and cellular health together

• Certified organic and non-GMO

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How We Tested the Supplements

Here’s something surprising: a lot of resveratrol supplements that look “high quality” on labels fall apart when you check the details. Either the dose doesn’t match what’s been used in studies, or the form is one your body barely absorbs.

I’ve seen this frustration over and over with health-conscious adults I’ve worked with. They’re not looking for fancy marketing; they just want to know what actually works.

So, for this list, we looked at the basics that matter: form (trans-resveratrol, micronized, liposomal), clinical-level dosages, and supporting ingredients like NMN, quercetin, or BioPerine®. 

We cross-checked purity, non-GMO or gluten-free certifications, and third-party lab reports. Then we went further, reading through hundreds of customer reviews across Amazon, forums, and brand sites to see what people really noticed.

The result? Seven supplements that align with real science and real experiences, not hype.

What is Resveratrol?

Most people know resveratrol as “the red wine antioxidant,” but here’s the truth: you’d need dozens of glasses to match the amounts studied for health. Not practical. Not safe either. That’s where supplements come in.

Resveratrol belongs to a family of plant compounds called polyphenols. They act like cellular shields, protecting against oxidative stress and supporting processes tied to aging and inflammation. 

What makes resveratrol interesting is its ability to activate proteins called sirtuins, molecular switches that influence how your cells repair DNA, handle stress, and manage energy.

I’ve seen clients in their 40s and 50s add resveratrol alongside other lifestyle changes and notice steadier energy within weeks. 

Not a miracle pill, but it helps set the stage for healthier aging.

How Resveratrol Works

Think of your cells like smartphone batteries. Over time, they don’t hold a charge as well. They drain faster, recharge slower. Resveratrol helps counter that by improving energy efficiency at the mitochondrial level and lowering oxidative stress.

Mechanistically, it activates SIRT1, one of the sirtuins tied to aging and metabolism. It’s also been shown to increase nitric oxide, which relaxes blood vessels and improves circulation. That’s why researchers link it to better cardiovascular and brain health. 

In one clinical trial, postmenopausal women taking resveratrol for six months improved cognitive performance by 33%. That’s not theory, that’s measurable change.

But here’s a myth worth addressing: more isn’t always better. Ultra-high doses of antioxidants can interfere with your body’s own stress-response systems. Balance matters more than brute force.

Because resveratrol itself absorbs poorly, modern formulas use trans-resveratrol, micronized particles, or liposomal delivery. 

Some pair it with BioPerine® or NMN for better uptake and synergy. If you’re considering adding it, the smart move is to check your label for these details before buying.

NMN + RESVERATROL

Cellular NAD+ booster with ultra‑pure NMN and Resveratrol, at research‑backed doses.*

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What are the Benefits of Resveratrol?

Resveratrol has been studied for years, mainly for its antioxidant and anti-inflammatory effects. While much of the evidence still comes from lab or animal studies, human research is growing. 

Disclaimer:

The benefits discussed below are based on scientific studies, many of which are in animals or cells and may not apply directly to humans. Human research is ongoing, and no single study should be taken as fact. This content is for educational purposes only and not a substitute for medical advice.

Here are some of the key potential benefits:

• May support healthy blood pressure: Research suggests resveratrol can increase nitric oxide, helping blood vessels relax and lowering systolic blood pressure in some people (1).

• Can improve cholesterol and blood fats: In animal studies, resveratrol raised HDL (“good” cholesterol) and reduced oxidized LDL, a marker linked to artery plaque (2).

• May support healthy blood sugar and insulin sensitivity: Studies in animals show resveratrol helps the body use insulin more effectively while reducing oxidative stress tied to diabetes (3).

• Shows promise in brain health and memory: Some research connects resveratrol to slower cognitive decline by protecting neurons and limiting beta-amyloid buildup (4).

• May reduce joint pain: Animal studies suggest it can protect cartilage and reduce inflammation in arthritic joints (5).

• May extend lifespan in animals: Trials in worms, fish, and mice show resveratrol can activate longevity genes and mimic calorie restriction (6).

• Could have anti-cancer potential: Early lab studies indicate resveratrol may slow cancer cell growth and influence gene and hormone activity, though human evidence is still limited (7).

How to Choose the Best Resveratrol Supplement

Not all resveratrol supplements are created equal. Here are the factors worth paying attention to when choosing one:

Purity and form of resveratrol

Look for trans-resveratrol, the most active and studied form. Micronized or liposomal formats can improve absorption. A higher purity level (98% or more) means fewer fillers and a more concentrated product.

Absorption and delivery method

Your body doesn’t naturally absorb resveratrol well. Supplements that add BioPerine® (black pepper extract) or use liposomal delivery are often more effective because they help your system take in more of the compound.

Dosage per serving

Most studies use daily doses between 250 mg and 1000 mg. Start on the lower side if you are new to resveratrol, and talk to your doctor if you are unsure where to begin.

Added ingredients for synergy

Some formulas pair resveratrol with NMN, NR, quercetin, or other antioxidants. These blends may offer broader benefits for energy, longevity, and anti-aging.

Brand reputation and testing

Choose companies that share their sourcing and provide third-party test results. Labels like non-GMO, vegan, or GMP-certified add an extra layer of trust.

Trans-Resveratrol vs. Cis-Resveratrol

Not all resveratrol is created equal. Trans-resveratrol is the form most studied, most stable, and most effective in the body. Cis-resveratrol, by comparison, is less stable, less bioavailable, and far less researched.

Both are isomers, same molecular formula, different structure, but trans-resveratrol holds its shape better under heat and light. That stability is what makes it the preferred form for activating sirtuins and supporting antioxidant defenses. 

Cis-resveratrol often forms when trans-resveratrol degrades, but it doesn’t deliver the same benefits for aging, blood flow, or inflammation.

When choosing a supplement, always check the label for “trans-resveratrol” and look for a purity rating of 98% or higher. That way you know you’re getting the form tied to real research on brain health, cardiovascular support, and longevity.

Who Should Take Resveratrol?

Resveratrol makes the most sense for adults who want support in aging well, protecting their heart, or keeping their brain sharp. It’s especially popular among people over 40, those managing high stress, or anyone looking to maintain steady energy and cellular health.

Many use it to counter oxidative stress, support blood sugar balance, and protect circulation. Others combine it with NMN or other NAD+ boosters for a more complete longevity approach. 

Some early studies also highlight benefits for postmenopausal women, people with joint stiffness, and those aiming to support memory.

If you often deal with fatigue, brain fog, or early signs of aging, or you’re simply proactive about long-term vitality, resveratrol may be worth adding to your daily routine. Just check in with your doctor first if you take blood thinners, diabetes medication, or other prescriptions.

Are Resveratrol Supplements Safe?

For most healthy adults, resveratrol is safe when taken in moderate amounts. Side effects are uncommon and usually mild, but some people report digestive issues like nausea or diarrhea at higher doses above 1000 mg per day.

Because resveratrol can influence blood clotting, it may interact with anticoagulants or diabetes drugs. If you’re pregnant, breastfeeding, or on prescription medication, it’s best to get medical guidance before starting.

And remember, antioxidants work best as part of a bigger lifestyle strategy. Resveratrol can help, but it’s not a magic bullet.

Resveratrol-Rich Foods and Beverages

While supplements provide a concentrated dose, you can also get small amounts of resveratrol through certain foods and drinks:

• Red grapes (especially the skins)

• Red wine

• Blueberries

• Cranberries

• Peanuts

• Dark chocolate

• Cocoa powder

• Japanese knotweed (used in many supplements)

These foods can complement your supplement routine and support your antioxidant intake naturally.

Alternatives to Resveratrol Supplements

If resveratrol isn’t the right fit for you or you’re looking to support healthy aging in other ways, there are several well-researched alternatives worth considering:

• NMN (Nicotinamide Mononucleotide): A direct precursor to NAD+, supports cellular energy, metabolism, and DNA repair. Often paired with resveratrol for added effect.

• Curcumin: The active compound in turmeric, known for its anti-inflammatory and antioxidant properties. Works well with black pepper extract for better absorption.

• Quercetin: A natural flavonoid found in onions and apples that may support immune health, reduce inflammation, and clear out senescent (aging) cells.

• Omega-3 Fatty Acids: Found in fish oil and flaxseed, these help reduce inflammation and support brain and heart health.

• CoQ10 (Ubiquinol): Supports mitochondrial energy production and cardiovascular function, especially helpful for older adults or those on statins.

Conclusion

Resveratrol is one of the most promising natural compounds for healthy aging, heart health, and cellular support. While research is still ongoing, current studies show encouraging results, especially when it's taken in the right form and dosage.

The best resveratrol supplement for you depends on your needs and budget. From high-purity capsules to powerful blends with NMN, there’s a quality option for everyone.

If you want a supplement that brings together energy support, healthy aging, and NAD+ optimization in one formula, Omre NMN + Resveratrol is the one we recommend most.

It combines two of the most effective ingredients in one convenient dose. Check availability to see if it’s in stock today.

FAQs

What is the best form of resveratrol to take?

The most effective form is trans-resveratrol, especially when it’s micronized or delivered in a liposomal form to improve absorption. Look for supplements that also include absorption enhancers like BioPerine®.

Can I take resveratrol every day?

Yes, daily use is generally safe and common. Most people take between 250mg to 500mg per day, but it's always good to start low and see how your body responds.

What time of day should I take resveratrol?

There’s no strict rule, but many people take it in the morning with food or healthy fat to help with absorption. Some prefer pairing it with other supplements like NMN or quercetin for better synergy.

Are there any side effects of resveratrol?

Most people tolerate resveratrol well. Mild side effects may include stomach upset or headache, especially at high doses. Taking it with food may help reduce discomfort.

Is resveratrol better with NMN or NR?

Both NMN and NR are NAD+ precursors that pair well with resveratrol. However, many experts and studies currently favor NMN for its direct role in NAD+ production. Combining it with resveratrol may offer stronger support for energy and cellular health.