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Did you know a natural compound found in strawberries might hold the key to healthier aging?
Fisetin, a plant-based flavonoid, has recently gained attention for its potential to support longevity, reduce inflammation, and protect against age-related diseases.
From brain health to cellular rejuvenation, fisetin benefits are being explored by researchers eager to unlock its full potential.
While the science is still unfolding, there’s plenty to get excited about when it comes to this natural powerhouse.
Quercetin + Fisetin
Quercetin and Fisetin help manage 'zombie' senescent cell burden and support cellular rejuvenation.*
What is Fisetin?
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Fisetin is a naturally occurring flavonoid found in fruits and vegetables like strawberries, apples, and onions. It’s gaining attention for its potential to promote healthy aging, reduce inflammation, and support cellular health.
At its core, fisetin is a type of polyphenol—a plant compound known for its antioxidant properties. It gives fruits like strawberries their color and is found in smaller amounts in apples, kiwis, and persimmons.
While you might be consuming fisetin without realizing it, the doses used in research are far higher than what you’d get from food alone.
What makes fisetin particularly intriguing is its potential as a “senolytic,” a compound that helps clear out old, dysfunctional cells (1). These cells, called senescent cells, can contribute to inflammation and aging.
Scientists are just beginning to explore how fisetin might help us age more gracefully by tackling these underlying issues.
How Fisetin Works in the Body
Fisetin works in the body by acting as an antioxidant, reducing inflammation, and studies suggest, it may be able to support the removal of old, damaged cells through its senolytic properties.
Antioxidants are like your body’s cleanup crew, protecting cells from damage caused by free radicals. Fisetin not only neutralizes these harmful molecules but also boosts the production of other antioxidants within the body, creating a ripple effect of cellular protection.
In addition to fighting oxidative stress, fisetin has been shown to calm inflammation by blocking the NF-κB pathway, a key driver of chronic inflammatory responses. This can have widespread benefits, as inflammation is linked to everything from arthritis to heart disease.
One of fisetin’s most exciting roles is its senolytic effect. By helping to clear out senescent cells, it may support healthier cellular function and even improve the way tissues and organs work over time.
Researchers are optimistic that this combination of effects could help pave the way for healthier aging.
Fisetin Benefits: What Makes It a Health Powerhouse?
Studies on animals and lab-based research suggest that fisetin has a lot of potential, but more human studies are needed to confirm its effects. Here’s what scientists have found so far:
- May Promote Longevity: Studies have found that fisetin helps regulate the mTOR pathway, a key mechanism in aging and cellular repair. By encouraging processes like autophagy (cellular cleanup), fisetin might help extend lifespan and improve overall health (2).
- Might Protect Brain Health: Research shows that fisetin can cross the blood-brain barrier in animals, helping to reduce inflammation in the brain and protect against memory loss. This has sparked interest in its potential as a supportive agent infor cognitive decline, although it’s still to be determined (3).
- Could Reduce Inflammation: By calming the NF-κB pathway, fisetin might reduce the kind of low-level inflammation that contributes to heart disease, diabetes, and other chronic conditions. Early studies in cells suggest it could play a role in managing inflammatory diseases (4).
- Supports Cardiovascular Health: Animal studies have shown that fisetin helps protect the heart from oxidative stress, reduces arterial stiffness, and improves circulation. These findings suggest it could support overall cardiovascular function (5).
- May Stabilize Blood Sugar Levels: Preliminary research indicates that fisetin might enhance insulin sensitivity and protect the pancreas from damage, helping to prevent blood sugar spikes and dips (6).
- Preserves Bone Density: By reducing the activity of bone-degrading cells called osteoclasts, fisetin has shown promise in maintaining bone strength in animal studies. This could be particularly helpful as we age (7).
The potential benefits are exciting, but remember: much of this research is still in its early stages. If you’re curious about fisetin, it’s worth keeping an eye on upcoming human studies to see how these findings translate.
Quercetin + Fisetin
Quercetin and Fisetin help manage 'zombie' senescent cell burden and support cellular rejuvenation.*
How to Incorporate Fisetin into Your Routine
Adding fisetin to your routine can be as simple as adjusting your diet or exploring supplements. Here’s how you can make it work for you.
Dietary Sources
You can naturally increase your fisetin intake by including certain fruits and vegetables in your meals:
Strawberries: The richest source, with 160 µg per gram.
Apples: Approximately 27 µg per gram.
Persimmons: Around 10 µg per gram.
Onions: About 5 µg per gram.
Grapes and Kiwis: Contain small amounts, roughly 2–4 µg per gram.
While these foods are nutritious, the amount of fisetin they provide is far below the doses used in research. For example, a serving of strawberries may only give you a fraction of the amount tested in studies, making supplementation a more practical option for therapeutic benefits.
Supplements
Fisetin supplements offer a convenient way to achieve the higher doses seen in research studies. These supplements often come in concentrated forms, making it easier to get the desired amount without eating large quantities of food.
When choosing a fisetin supplement, look for one that includes complementary ingredients to improve absorption. Pairing fisetin with healthy fats like coconut or olive oil can also enhance its bioavailability. Check for third-party testing to ensure purity and quality.
If you’re looking for a simple way to harness the combined power of these senolytic agents, products like Omre Quercetin + Fisetin provide an all-in-one solution.
This supplement combines both ingredients into a single formula, offering the benefits of cellular rejuvenation and antioxidant support in one dose.
For those interested in supporting longevity and reducing inflammation, this combination could be an ideal addition to your routine.
Potential Risks and Precautions
Fisetin is generally well-tolerated, but research on its long-term safety and side effects in humans is still limited (7).
The typical dosage of fisetin ranges from 100 to 500 mg per day. It’s always best to start with a lower dose and gradually increase based on how your body responds.
While animal studies show promising results, fisetin's effects in humans are still being explored, so caution is advised.
Pregnant or breastfeeding women, as well as individuals on medications, should consult a healthcare professional before starting fisetin supplementation.
Additionally, if you experience any unusual symptoms, it’s a good idea to discontinue use and discuss it with a doctor.
Conclusion
Fisetin has shown incredible potential as a natural compound to support longevity, reduce inflammation, and promote cellular health.
Whether you’re considering adding more fisetin-rich foods to your diet or exploring supplements, there are options to suit your needs.
While more human studies are needed, the early research is promising, and fisetin might be a valuable addition to your health regimen.
If you’re interested in trying a trusted supplement, Omre Quercetin + Fisetin offers a convenient way to get started. 
Check availability today to see how this powerful combination could support your journey to healthier aging.
FAQs
Can fisetin help with weight management?
Fisetin might indirectly support weight management by improving insulin sensitivity and reducing inflammation, but more human studies are needed to confirm its effects on weight loss. Currently, it is not considered to be a weight loss supplement.
Is fisetin safe to take with other supplements?
Fisetin is generally considered safe, but it’s a good idea to consult a healthcare provider before combining it with other supplements, especially those targeting inflammation or longevity.
Can fisetin improve skin health?
Fisetin’s antioxidant and anti-inflammatory properties might benefit skin health by protecting against oxidative stress, but research specifically on skin-related benefits is limited.
How long does it take to see results from fisetin supplementation?
Results can vary depending on the individual and the intended benefit. For senolytic effects, researchers often use short, high-dose protocols, but noticeable results may take months or longer
Is fisetin suitable for children?
Fisetin supplementation has not been extensively studied in children, so it’s best to avoid giving it to them unless advised by a pediatrician. Natural dietary sources, like fruits, are a safer option.