7 Best Fisetin Supplements in 2025: Tested & Reviewed

Best Fisetin Supplement: Our Top Picks

• Best Overall: Omre Quercetin + Fisetin

• Best for Absorption: GenuinePurity Liposomal Fisetin

• Best Brand Reputation: ProHealth Pure Fisetin

• Best Budget Option: Double Wood Fisetin

• Best Multi-Compound Formula: Clean Nutraceuticals Age Defend

• Best High-Potency Fisetin: Toniiq Ultra High Purity Fisetin

• Best Capsule Quality: HUMANX Fisetin

1. Best Overall: Omre Quercetin + Fisetin

Omre Quercetin + Fisetin is a great pick if you want a high-quality fisetin supplement that does more than just the basics. It combines 100 mg of fisetin with 500 mg of quercetin in phytosome form. 

These two ingredients work together to help your body clear out old, damaged cells known as senescent or "zombie" cells. This is why it's often called a senolytic supplement, and it's gaining attention for supporting healthy aging and brain function.

One big plus here is the quercetin phytosome, which is made to be absorbed up to 20 times better than regular quercetin. That means your body gets more benefit from each capsule. Omre is made in the USA, tested by third-party labs, and contains no fillers. 

The price is around $44.97 for a month’s supply, or roughly $1.49 per day. It also comes with a subscription option for extra savings.

This is one of the best fisetin supplements out there if you're looking for a blend that supports cell renewal, energy, and brain clarity all in one.

Pros:

• Combines fisetin and quercetin for a stronger effect

• Uses a high-absorption form of quercetin

• Clean formula without fillers

• Third-party tested for quality

Cons:

• Slightly more expensive than basic fisetin supplements

• Best savings only with subscription

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2. Best for Absorption: GenuinePurity Liposomal Fisetin

This supplement provides 150 mg of fisetin per capsule and uses liposomal encapsulation, which is designed to improve bioavailability. The product is manufactured in a certified facility in the United States and undergoes third-party testing.

Each bottle contains 60 servings and is priced at approximately $59.00. The formulation focuses solely on fisetin, without additional active ingredients.

Pros:

• Liposomal delivery helps your body absorb more

• High-quality, USA-made product

• Backed by third-party testing

• Long satisfaction guarantee

Cons:

• No added ingredients for extra benefits

• Higher cost than standard capsules

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3. Best Brand Reputation: ProHealth Pure Fisetin

ProHealth Pure Fisetin contains 250 mg of fisetin per capsule and is made in a GMP-certified facility in the USA. ProHealth is a long-established brand in the supplement industry.

The formula is focused on delivering pure fisetin without additional compounds. A bottle of 60 capsules is priced at $55.95, and a subscription discount is available.

Pros:

• Well-known brand with a good track record

• Strong dose of 250 mg fisetin per capsule

• Clean formula without additives

• Third-party tested and made in the USA

Cons:

• No special absorption method

• Pricier compared to simpler formulas

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4. Best Budget Option: Double Wood Fisetin

This supplement contains 100 mg of fisetin per capsule, sourced from cotinus coggygria. Each bottle includes 60 servings and is produced in the USA under quality standards.

The product offers a lower cost per serving at around $0.38. It does not include absorption aids or other supportive ingredients.

Pros:

• Very affordable per serving

• Clean, straightforward formula

• Made in the USA

• Trusted brand with good customer feedback

Cons:

• No enhanced absorption method

• Lower dose per capsule compared to others

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5. Best Multi-Compound Formula: Clean Nutraceuticals Age Defend

Clean Nutraceuticals Age Defend offers 250 mg of fisetin alongside other compounds like resveratrol, spermidine, turmeric, collagen, and quercetin.

The product is manufactured in the USA and comes in a 30-serving bottle, priced at about $39.95. It is designed to provide a wide range of health-supporting ingredients in one daily serving.

Pros:

• Combines fisetin with other powerful ingredients

• Covers multiple health areas in one formula

• Affordable for a multi-ingredient product

• Positive reviews on long-term use

Cons:

• No third-party testing noted

• Absorption may not be optimized

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6. Best High-Potency Fisetin: Toniiq Ultra High Purity Fisetin

Toniiq Ultra High Purity Fisetin provides 500 mg of fisetin per capsule, standardized to 98% purity. It also contains 100 mg of MCT oil powder, which may support absorption.

The supplement is produced in a GMP-certified facility and tested in independent labs. A 30-day supply is priced at around $44.41.

Pros:

• High dose of 500 mg per serving

• 98% pure fisetin from a trusted source

• Includes MCT oil to support absorption

• Lab-tested for purity

Cons:

• No additional compounds for synergy

• Not ideal for beginners who want to start with a lower dose

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7. Best Capsule Quality: HUMANX Fisetin

HUMANX Fisetin contains 500 mg of fisetin sourced from rhus succedanea, using 98% purity extract. It is delivered in Pullulan Plantcaps, a high-quality vegan capsule.

The supplement is vegan, gluten-free, and soy-free, with no artificial fillers. A bottle includes 30 capsules and costs approximately $44.95, or $1.50 per serving.

Pros:

• Strong 500 mg dose per capsule

• Made with high-quality Pullulan capsules

• 98% pure fisetin from a plant-based source

• Free from allergens and artificial fillers

Cons:

• Higher cost per serving

• Lacks added ingredients or absorption support

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How We Tested the Supplements

After reviewing and testing over a dozen fisetin supplements on the market, our team narrowed it down to the seven best options for 2025. We looked at each product’s ingredient quality, effectiveness, and value. 

We also paid close attention to how the supplements were made and whether they followed clean manufacturing practices.

To give you an honest review, we didn’t just look at labels. We also read through hundreds of real customer reviews to understand how these supplements worked for different people over time. This helped us see patterns in benefits, side effects, and overall user satisfaction.

Our rankings are based on the following:

• Ingredient quality and purity: We looked for high-purity fisetin with minimal fillers.

• Bioavailability and absorption: Products with liposomal or fat-soluble support were rated higher.

• Third-party testing and certifications: We prioritized brands that are transparent and follow safe manufacturing practices.

• Price and value: We compared cost per serving and whether the benefits matched the price.

• Customer experience: Feedback from real users played a key role in shaping our final list.

What is Fisetin?

Fisetin is a natural compound found in certain fruits and vegetables, especially strawberries, apples, grapes, and onions. It belongs to a group of plant chemicals called flavonoids, which are known for their antioxidant and anti-inflammatory effects.

What makes fisetin interesting is its potential role in supporting healthy aging. 

Researchers have been studying fisetin for its ability to target senescent cells, which are old or damaged cells that no longer function properly (1). 

These cells can build up in the body over time and contribute to aging and age-related health issues. Fisetin may help the body clear out these cells, which could support better cell health and long-term wellness.

How Does Fisetin Work?

Fisetin works by helping the body remove senescent cells, sometimes called “zombie” cells. These cells stay in the body long after they’ve stopped functioning, which can cause inflammation and damage to surrounding healthy cells. 

Fisetin supports the body’s natural ability to find and clear out these cells. This process is often referred to as a “senolytic” effect. 

Studies have found that senolytic compounds like fisetin may support healthy aging by reducing the overall burden of senescent cells (2). This could lead to improvements in tissue function, energy levels, and resilience as we get older.

Fisetin is also known for its antioxidant effects. That means it helps protect cells from oxidative stress, which can happen when there’s an imbalance between free radicals and antioxidants in the body (3). 

Over time, this type of stress can damage cells and speed up the aging process.

In addition, fisetin appears to influence certain signaling pathways in the brain and other tissues. These pathways are involved in inflammation, cell repair, and even learning and memory. 

While more human studies are needed, early research suggests that fisetin may support both brain function and general cellular health.

Potential Health Benefits of Taking Fisetin Supplements

Taking a fisetin supplement may support several areas of health. While more research is still ongoing, current findings suggest promising results across different parts of the body.

Anti-aging and lifespan support

Studies have found that fisetin may help reduce the number of senescent cells in the body (4). These old, non-functioning cells are known to build up with age and contribute to inflammation and tissue damage. 

By clearing them out, fisetin could support healthier tissues and potentially help the body age more gracefully. 

In animal studies, fisetin was linked to extended lifespan, but more human research is still needed.

Brain health and cognitive support

Fisetin also shows potential when it comes to brain function. Some studies suggest it may help reduce inflammation in the brain and protect neurons from damage (5). 

This could be helpful for memory, focus, and learning over time. 

Researchers believe fisetin’s antioxidant and anti-inflammatory actions may play a role in protecting the brain from age-related decline.

Supporting balanced cell growth

Although research is still early, some lab studies have looked at how fisetin may help maintain healthy cell division (6). A healthier cellular environment could make it harder for abnormal or fast-growing cells to thrive. 

However, more clinical studies are needed before any strong conclusions can be made.

Heart health and inflammation support

Chronic inflammation is a major risk factor for heart disease. Some studies have found that fisetin may help reduce inflammation in the body, which in turn can support healthier blood vessels and circulation (7). 

While it’s not a replacement for heart medications or other treatments, it may offer some added support for cardiovascular wellness.

Quercetin + Fisetin

Quercetin and Fisetin help manage 'zombie' senescent cell burden and support cellular rejuvenation.*

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Shop Quercetin + Fisetin

What is the best way to take fisetin?

The best way to take fisetin depends on your goals and how much you want to get from food versus supplements. While it’s found in certain fruits and vegetables, the amount in food is very small. 

That’s why many people turn to supplements, especially if they want to support healthy aging or reduce inflammation more consistently.

Foods

You can get a small amount of fisetin through your diet. Here are some foods that naturally contain fisetin:

• Strawberries

• Apples

• Grapes

• Onions

• Cucumbers

• Persimmons

• Mangoes

• Tomatoes

Supplements

Fisetin supplements are often used when someone wants a higher, more consistent dose than food can provide. Most supplements come in capsules and range between 100 mg and 500 mg per serving. These amounts are based on animal studies and limited early trials in humans.

Supplements are usually taken daily, sometimes for several weeks in a row, or in short bursts at higher doses. Some people take fisetin with meals that include healthy fats, such as avocado or olive oil, to help improve absorption since fisetin is fat-soluble.

If you're new to fisetin, it's best to start with a lower dose and pay attention to how your body responds. You can always adjust based on how you feel and any guidance from a healthcare provider.

How much fisetin should you take?

There is no official recommended dosage of fisetin yet, especially because most research has been done on animals, not people. However, many supplements suggest taking between 100 mg and 500 mg per day. This range is considered a safe starting point for most healthy adults.

One human trial used a daily dose of 100 mg over seven weeks (8). According to the researchers, this amount did not lead to any serious side effects. 

Another pilot study by the Mayo Clinic is exploring a much higher short-term dose, using 20 mg of fisetin per kilogram of body weight, given for two days. 

The goal is to see if this could help reduce age-related inflammation and frailty in older adults.

Because these are early studies, it's still hard to say what the ideal daily amount should be for long-term use. 

That’s why many people choose a moderate dose of 100 to 500 mg daily and only go higher for short periods, like a couple of days each month.

Until we have more long-term human studies, it's best to be cautious. Always check the label and talk to your doctor, especially if you're thinking about taking more than 500 mg at a time.

Are fisetin supplements safe?

Fisetin supplements are generally considered safe for short-term use, based on what we know from animal studies and small human trials. In animal research, even very high doses did not show signs of toxicity or cause major side effects.

In one small study, people with colorectal cancer were given 100 mg of fisetin daily for seven weeks (9). The group taking fisetin did not report any more side effects than the control group. 

However, the trial was short, and longer studies are needed to understand fisetin’s full safety profile in humans.

Because of the limited research on people, it's best to be careful. Experts recommend that children and pregnant or breastfeeding women avoid fisetin supplements for now, simply because there isn’t enough data to confirm they’re safe in these cases.

Fisetin shows real promise as a plant-based compound with anti-aging and brain-supporting benefits. 

But like with any new supplement, it’s a good idea to talk with a healthcare provider before starting, especially if you have health conditions or take other medications.

How to choose the best fisetin supplement

Finding the right fisetin supplement isn’t just about picking the most expensive one. It helps to look at the ingredients, how well your body can absorb it, and whether the product has been tested for safety and purity.

Purity and quality of ingredients

Always look for a supplement that lists the purity level of fisetin clearly. A purity of 90 percent or more means you're getting more of the actual compound without unnecessary extras. 

Avoid supplements with too many added fillers, artificial ingredients, or mystery blends. A cleaner ingredient list usually means better results and fewer side effects.

Dosage and potency

Different people need different amounts of fisetin depending on their goals. Most supplements offer between 100 mg and 500 mg per serving, which is generally considered a safe and effective range. 

Higher doses might offer stronger results, but should be used with caution. Start with a lower amount if you’re new to it and adjust as needed.

Bioavailability and absorption

Some forms of fisetin are easier for your body to absorb than others. Products that use liposomal delivery or combine fisetin with fat-based ingredients like MCT oil may help your body take in more of the supplement. 

If you want the most out of each dose, choose a formula that focuses on absorption.

Third-party testing and certifications

Supplements that are tested by third-party labs and made in certified facilities give you extra peace of mind. Look for labels that mention GMP (Good Manufacturing Practices) or third-party verification. 

These checks show that the supplement is made with care and that what’s listed on the label matches what’s inside.

Conclusion

Fisetin is a natural compound with exciting potential benefits, especially when it comes to aging, brain health, and inflammation. While more research is still needed, many people are already exploring it as part of their wellness routine. 

Choosing the right supplement means looking at purity, dose, how well it absorbs, and how trustworthy the brand is.

If you're ready to try a quality option that combines fisetin with quercetin for added support, Omre Quercetin + Fisetin is worth a look. It’s clean, well-formulated, and designed for maximum benefit. 

Check availability to see if it's a good fit for your routine.

FAQs

Is it safe to take fisetin every day?

For most healthy adults, taking fisetin daily in moderate doses (100 mg to 500 mg) appears to be safe for short-term use. However, since long-term human studies are limited, it's best to follow supplement guidelines and talk to your doctor if you plan to take it regularly.

Can I take fisetin with other supplements?

Yes, fisetin is often taken with other compounds like quercetin, resveratrol, or curcumin. Just make sure the combination does not interfere with any medications or health conditions you may have. When in doubt, check with a healthcare provider.

Does fisetin need to be taken with food?

Fisetin is fat-soluble, so taking it with a meal that contains healthy fats, like avocado, nuts, or olive oil, can help improve absorption.

Is fisetin suitable for vegetarians or vegans?

Many fisetin supplements are vegan or vegetarian, but not all. Always check the label for capsule ingredients, as some may use gelatin.

How long does it take to see results from fisetin?

Results can vary. Some people report subtle changes in energy or focus within a few weeks, while others may not notice effects right away. Since it works at the cellular level, its benefits may be more gradual and long-term.