7 Best Fisetin Supplements in 2026: Tested & Reviewed

Top Fisetin Supplements at a Glance

Here’s a quick side-by-side look at the leading fisetin supplements this year. 

Best Fisetin Supplement: Our Top Picks

• Best Overall: Omre Quercetin + Fisetin

• Best for Absorption: GenuinePurity Liposomal Fisetin

• Best Brand Reputation: ProHealth Pure Fisetin

• Best Budget Option: Double Wood Fisetin

• Best Multi-Compound Formula: Clean Nutraceuticals Age Defend

• Best High-Potency Fisetin: Toniiq Ultra High Purity Fisetin

• Best Capsule Quality: HUMANX Fisetin

1. Best Overall: Omre Quercetin + Fisetin

If you are looking for a balanced and thoughtful formula, Omre Quercetin + Fisetin is a strong option. It combines 100 mg of fisetin with 500 mg of quercetin phytosome, a form of quercetin designed to be absorbed more efficiently than standard quercetin.

Fisetin and quercetin are often studied together because they may support natural cellular cleanup processes linked to healthy aging. 

Some research suggests these compounds may play a role in how the body handles older or stressed cells, though human data is still developing.

A notable feature here is the quercetin phytosome, which helps improve absorption compared to regular quercetin. Omre is made in the United States, third-party tested, and formulated without unnecessary fillers. For people who want fisetin paired with a well-studied flavonoid in one capsule, this blend is worth considering.

Pros:

• Combines fisetin with quercetin in one formula

• Uses a more absorbable form of quercetin

• Clean ingredient list with no fillers

• Third-party tested for quality

Cons:

• Costs more than single-ingredient fisetin products

• Best value usually comes with a subscription

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2. Best for Absorption: GenuinePurity Liposomal Fisetin

GenuinePurity Liposomal Fisetin focuses on delivery and simplicity. Each capsule contains 150 mg of fisetin using liposomal encapsulation, a method often used to help nutrients move through digestion more efficiently.

Liposomal delivery may help protect fisetin as it passes through the digestive system, which can be helpful for people who are sensitive to standard capsules. This product is made in the United States in a certified facility and is third-party tested for purity and consistency.

There are no added ingredients here. Just fisetin in a format designed to support absorption. This makes it a good choice for those who prefer a single-ingredient supplement without extras.

Pros:

• Liposomal form designed for better absorption

• Made in the USA with third party testing

• Simple formula without fillers or additives

• Often gentle on digestion

Cons:

• Does not include complementary ingredients

• Higher price than basic fisetin capsules

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3. Best Brand Reputation: ProHealth Pure Fisetin

ProHealth Pure Fisetin is often chosen for its long-standing reputation in the longevity space. ProHealth has been around for many years and is known for transparent sourcing and consistent quality standards.

Each capsule provides 250 mg of pure fisetin and is produced in a GMP-certified facility in the United States. The formula is straightforward, with no fillers or unnecessary ingredients.

While this product does not include special delivery technology, many people prefer it for the brand’s history, testing practices, and clean labeling. It can be a solid option for those who value trust and simplicity.

Pros:

• Well-established and trusted supplement brand

• Higher fisetin amount per capsule

• Clean formula with no fillers

• Made in the USA under GMP standards

Cons:

• No added absorption support

• Slightly higher cost than basic options

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4. Best Budget Option: Double Wood Fisetin

Double Wood Fisetin is a practical choice for people who want to try fisetin without spending too much. It offers a straightforward formula that focuses on quality and consistency rather than extra features.

Each capsule contains 100 mg of fisetin sourced from Cotinus coggygria, a common plant source used in many fisetin supplements. 

The product is made in the United States, third-party tested, and free from artificial additives. While it does not include ingredients designed to improve absorption, many users appreciate its simple and reliable approach.

This option may suit beginners or those who prefer a lower dose at a more accessible price point.

Pros:

• Affordable cost per serving

• Simple, single-ingredient formula

• Made in the USA with third-party testing

• Widely used and well-reviewed brand

Cons:

• No ingredients added to support absorption

• Lower dose compared to higher strength options

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5. Best Multi-Compound Formula: Clean Nutraceuticals Age Defend

Clean Nutraceuticals Age Defend takes a broader view of healthy aging by combining fisetin with several other well-studied compounds. Alongside 250 mg of fisetin, the formula includes ingredients such as resveratrol, spermidine, curcumin, collagen, and quercetin.

This type of blend may appeal to people who prefer an all-in-one supplement rather than managing several separate products. 

Each ingredient is commonly researched for its potential role in cellular health, inflammation balance, or tissue support, although research on combined formulas is still evolving.

Third-party testing is not clearly stated, but the brand has a solid customer following and is often chosen for convenience and value.

Pros:

• Combines fisetin with multiple aging-related compounds

• Supports several biological pathways in one formula

• Convenient option for daily use

• Reasonable value for a multi-ingredient supplement

Cons:

• No clear third-party testing information

• Absorption may vary across ingredients

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6. Best High-Potency Fisetin: Toniiq Ultra High Purity Fisetin

Toniiq Ultra High Purity Fisetin is designed for those looking for a higher strength option. Each capsule provides 500 mg of fisetin standardized to 98 percent purity, which is among the more concentrated forms available.

The formula also includes MCT oil powder, which may help support the absorption of fat-soluble compounds like fisetin. Toniiq tests each batch through independent labs and produces its supplements in GMP-certified facilities.

Due to the higher dose, this product may be better suited for experienced users or those following a specific supplementation plan discussed with a healthcare professional.

Pros:

• High fisetin amount per capsule

• Standardized to 98 percent purity

• Includes MCT oil to support absorption

• Independently tested and GMP produced

Cons:

• Higher doses may not suit beginners

• Does not include complementary flavonoids

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7. Best Capsule Quality: HUMANX Fisetin

HUMANX Fisetin places a strong focus on purity and capsule quality. Each serving provides 500 mg of fisetin at 98 percent purity, derived from Rhus succedanea, and is delivered in plant-based Pullulan capsules.

Pullulan capsules are often chosen for their stability and clean profile. This product is vegan, gluten-free, and soy-free, which can be helpful for people with dietary sensitivities. HUMANX avoids artificial binders and preservatives, keeping the formula simple and consistent.

While there are no added ingredients to support absorption, many users choose this supplement for its clean labeling and reliable dosing.

Pros:

• High-purity fisetin per serving

• Uses Pullulan plant-based capsules

• Free from common allergens

• Vegan-friendly and filler-free

Cons:

• Higher cost per serving

• No added absorption or synergy ingredients

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Quercetin + Fisetin

Quercetin and Fisetin help manage 'zombie' senescent cell burden and support cellular rejuvenation.*

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Shop Quercetin + Fisetin

What is Fisetin?

Fisetin is a natural plant compound found in foods like strawberries, apples, grapes, and onions, and it is studied for its potential role in healthy aging. It is a type of flavonoid, a group of nutrients known for supporting cell health and antioxidant activity.

As we age, some damaged cells stop functioning properly but remain in the body. These cells, often called senescent cells, can release signals linked to inflammation and tissue stress. 

Research suggests fisetin may help the body reduce the buildup of these cells, supporting normal cell renewal.

Because of this, fisetin is being studied for its possible benefits in aging, cognitive health, and overall cellular resilience, though research is still ongoing and evolving (1).

How Does Fisetin Work?

Fisetin works by supporting the body’s natural process of clearing out damaged cells and protecting healthy ones. It is studied for its senolytic activity, which refers to how certain compounds may help reduce the buildup of senescent cells that contribute to inflammation and tissue stress.

These senescent cells stop working properly but remain in the body, where they can affect nearby healthy cells. Research suggests fisetin may help the body identify and clear these cells, which could support healthier aging at the cellular level. 

Studies on senolytic compounds, including fisetin, link this process to improved tissue function and resilience over time, although much of the research is still ongoing (2).

Fisetin also has antioxidant properties, meaning it may help protect cells from oxidative stress caused by free radicals (3). 

In addition, early research shows fisetin may influence signaling pathways involved in inflammation, cell repair, and brain function. 

While more human studies are needed, these combined actions help explain why fisetin is being studied for both cellular and cognitive support.

Potential Health Benefits of Taking Fisetin Supplements

Fisetin is studied for how it may support the body as it ages, especially at the cellular level. Research is still developing, but early findings suggest fisetin may play a role in healthy aging, brain function, and inflammation balance. 

Below is a clear look at what current studies suggest, without overstating the evidence.

Anti-aging and Lifespan Support

Studies suggest fisetin may help reduce the buildup of senescent cells in the body, which tend to increase with age and are linked to inflammation and tissue stress (4). 

By supporting the body’s natural cell cleanup processes, fisetin may help maintain healthier tissues over time. Animal studies have also linked fisetin to longer lifespan, though human research is still limited and ongoing.

Brain Health and Cognitive Support

Some research suggests fisetin may support brain health by helping reduce inflammation and oxidative stress in nervous tissue (5). These effects may be relevant for memory, focus, and learning as people age. 

Researchers believe fisetin’s antioxidant and anti-inflammatory properties may help protect neurons, but more human studies are needed to better understand its long-term role.

Supporting Balanced Cell Growth

Early lab studies have explored how fisetin may influence normal cell division and cellular balance (6). 

A healthier cellular environment may make it harder for abnormal cells to grow unchecked. These findings are preliminary, and clinical research is still needed before drawing firm conclusions.

Heart Health and Inflammation Support

Ongoing inflammation plays a role in many heart-related conditions. Some studies suggest fisetin may help support a balanced inflammatory response, which can be important for blood vessel and circulation health (7). 

While it should not replace medical treatment, fisetin may offer gentle, supportive benefits as part of a broader heart-healthy lifestyle.

How Much Fisetin Should You Take?

There is no official recommended dose for fisetin, but most supplements suggest between 100 mg and 500 mg per day. This range is commonly used by healthy adults and is based on early research and practical use. 

One small human study used 100 mg daily for seven weeks without serious side effects (8). Another pilot study from the Mayo Clinic is exploring higher short-term dosing to study its effects on inflammation and frailty.

Because human research is still limited, many people choose moderate daily amounts and avoid high doses unless advised by a healthcare professional. 

Taking fisetin with food and at the same time each day may help with consistency and tolerance. If you are considering higher doses or have a medical condition, it is best to speak with your doctor first.

Are Fisetin Supplements Safe?

Fisetin supplements appear to be generally safe for short-term use in healthy adults, based on early animal research and small human studies. 

High-dose animal studies have not shown signs of toxicity, and in a small human trial using 100 mg daily for seven weeks, participants did not report more side effects than the control group (9). However, these studies were limited in size and length.

Because long-term human data is still limited, cautious use is advised. 

Children and people who are pregnant or breastfeeding are usually advised to avoid fisetin supplements for now due to a lack of safety data. 

Anyone taking medications or managing a health condition should speak with a healthcare provider before starting fisetin, especially at higher doses.

How to Choose the Best Fisetin Supplement

Choosing a fisetin supplement can feel confusing at first, especially when many products make similar claims. Focusing on a few clear quality markers can help you narrow it down and choose with more confidence.

• Purity and ingredient quality: Look for supplements that clearly list fisetin purity, ideally 90 percent or higher. This helps reduce the chance of fillers or unnecessary additives. Simple formulas with full ingredient disclosure are usually easier to evaluate and tolerate.

• Dosage and potency: Most fisetin supplements provide between 100 mg and 500 mg per capsule. If you are new, starting at a lower dose and increasing slowly may help your body adjust. Steady, consistent use tends to matter more than taking a high dose right away.

• Absorption and bioavailability: Fisetin is not easily absorbed on its own. Products that use liposomal delivery, phytosome forms, or fat-based carriers like MCT oil may help improve how much your body can use from each dose.

• Third-party testing and manufacturing standards: Reputable brands often use independent lab testing and produce supplements in GMP-certified facilities. These steps help confirm that the product contains what the label claims and meets basic safety standards.

• Brand transparency and reputation: Choose companies that are open about sourcing, testing, and quality control. Brands that share research references and offer clear customer support policies tend to be more reliable over time.

Conclusion

Fisetin is gaining attention because of how it may support healthy aging at the cellular level. Research so far suggests it may help with natural cell cleanup, inflammation balance, and brain support, though human studies are still limited and ongoing. 

As with any supplement, quality matters. Factors like purity, dosage, absorption method, and third-party testing make a real difference in how a product performs and how confident you can feel using it.

If you decide to try fisetin, starting with a moderate dose, choosing a transparent brand, and checking with a healthcare professional is a smart approach. Supplements work best when they fit into a broader healthy lifestyle that includes good nutrition, movement, and sleep.

At Omre, we formulated Omre Quercetin + Fisetin with this balanced approach in mind. We focused on clean ingredients, thoughtful dosing, and enhanced absorption using quercetin phytosome, all backed by third-party testing.

 If you are looking for a simple, well-rounded option that aligns with current research and safety standards, you can explore Omre Quercetin + Fisetin and see if it fits your routine.

FAQs

Is it safe to take fisetin every day?

For most healthy adults, daily fisetin in the 100 mg to 500 mg range appears well tolerated in short term studies. Because long-term human data is limited, it is best to follow label guidance and speak with a healthcare professional if you plan ongoing daily use.

Can I take fisetin with other supplements?

Fisetin is commonly paired with compounds like quercetin, resveratrol, or curcumin for convenience. If you take prescription medications or supplements that affect blood clotting or blood pressure, checking with your doctor first is a sensible step.

Does fisetin need to be taken with food?

Fisetin is fat-soluble, so taking it with a meal that contains some healthy fat may help absorption. Even so, consistency matters most, and many people take it with their regular meals to keep the routine simple.

Is fisetin suitable for vegetarians or vegans?

Many fisetin supplements are suitable for vegetarians or vegans, but capsule materials can vary by brand. Checking whether the product uses plant-based capsules, such as cellulose or pullulan, can help you choose one that fits your dietary preferences.

How long does it take to see results from fisetin?

Fisetin works at the cellular level, so any noticeable changes tend to develop gradually rather than quickly. Some people report subtle changes within a few weeks, while others may need longer periods of consistent use, as individual responses can vary.