7 Best Fisetin Supplements in 2025: Tested & Reviewed

Top Fisetin Supplements at a Glance

Here’s a quick side-by-side look at the leading fisetin supplements this year.

Best Fisetin Supplement: Our Top Picks

• Best Overall: Omre Quercetin + Fisetin

• Best for Absorption: GenuinePurity Liposomal Fisetin

• Best Brand Reputation: ProHealth Pure Fisetin

• Best Budget Option: Double Wood Fisetin

• Best Multi-Compound Formula: Clean Nutraceuticals Age Defend

• Best High-Potency Fisetin: Toniiq Ultra High Purity Fisetin

• Best Capsule Quality: HUMANX Fisetin

1. Best Overall: Omre Quercetin + Fisetin

If your goal is to age slowly, gracefully and naturally, Omre Quercetin + Fisetin is a standout choice.

It combines 100 mg of fisetin with 500 mg of quercetin phytosome, a highly bioavailable form absorbed up to 20 times better than standard quercetin.

These two ingredients work together to help your body clear out old, damaged cells known as senescent or "zombie" cells. This is why it's often called a senolytic supplement, and it's gaining attention for supporting healthy aging and brain function.

One big plus here is the quercetin phytosome, which is made to be absorbed up to 20 times better than regular quercetin. That means your body gets more benefit from each capsule. Omre is made in the USA, tested by third-party labs, and contains no fillers. 

This is one of the best fisetin supplements out there if you're looking for a blend that supports cell renewal, energy, and brain clarity all in one.

Pros:

• Combines fisetin and quercetin for a stronger effect

• Uses a high-absorption form of quercetin

• Clean formula without fillers

• Third-party tested for quality

Cons:

• Slightly more expensive than basic fisetin supplements

• Best savings only with subscription

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2. Best for Absorption: GenuinePurity Liposomal Fisetin

GenuinePurity Liposomal Fisetin delivers 150 mg of pure fisetin per capsule and uses liposomal encapsulation, one of the most effective delivery systems for enhancing nutrient absorption.

Liposomal encapsulation helps fisetin bypass the harsh digestive process and enter the bloodstream more efficiently, meaning your body gets more of the active compound where it counts.

This supplement is manufactured in the United States in a certified facility and goes through third-party testing to ensure purity and potency. GenuinePurity focuses on simplicity: no fillers, no artificial ingredients, just clean, high-quality fisetin.

It’s an excellent option for those who value bioavailability and digestive comfort over added ingredients.

Pros:

• Liposomal delivery for higher absorption

• High-quality, USA-made product

• Third-party tested for purity and consistency

• 100% clean formulation
  
  

Cons:

• No added compounds for extra benefits

• Slightly higher cost compared to standard capsules
  
  

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3. Best Brand Reputation: ProHealth Pure Fisetin

ProHealth Pure Fisetin stands out for trust and quality. ProHealth is a long-established longevity brand with a strong reputation among health professionals and consumers alike.

Each capsule provides 250 mg of pure fisetin, manufactured in a GMP-certified, USA-based facility. It contains no additives or unnecessary fillers. Only the active ingredient in its most natural form.

ProHealth’s long track record and commitment to third-party testing make this an excellent choice for those who want a supplement from a company with proven transparency and integrity.

Pros:

• Reputable, established longevity brand

• Strong 250 mg fisetin dosage per capsule

• Clean, filler-free formula

• Made in the USA under GMP standards

Cons:

• No enhanced absorption technology

• Slightly pricier than simpler brands

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4. Best Budget Option: Double Wood Fisetin

For those starting their longevity journey or seeking value without compromise, Double Wood Fisetin offers an affordable, high-quality entry point.

Each capsule delivers 100 mg of fisetin, sourced from Cotinus coggygria (the same plant used in many premium fisetin extracts). The formula is made in the USA, third-party tested, and free from artificial additives.

While it doesn’t include absorption enhancers like MCT oil or phospholipids, Double Wood remains one of the most trusted and accessible options for beginners who want consistent results at a reasonable price.

Pros:

• Affordable price per serving

• Simple, one-ingredient formulation

• Made in the USA under strict standards

• Trusted brand with strong customer feedback

Cons:

• No absorption-enhancing compounds

• Lower dose compared to higher-end formulas
  
  

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5. Best Multi-Compound Formula: Clean Nutraceuticals Age Defend

Clean Nutraceuticals Age Defend takes a broader approach to healthy aging.   Instead of focusing solely on fisetin, it combines 250 mg of fisetin with  resveratrol, spermidine Curcumin, Collagen, and Quercetin — creating a multi-pathway anti-aging supplement that supports cellular health, skin integrity, and inflammation control.

This formulation appeals to those who prefer an “all-in-one” longevity blend without juggling multiple supplements. It’s a convenient way to support multiple aging-related pathways simultaneously.

While third-party testing isn’t explicitly mentioned, Clean Nutraceuticals maintains solid customer satisfaction and offers strong long-term value.

Pros:

• Combines fisetin with several proven longevity compounds

• Targets multiple aspects of aging and inflammation

• Convenient, one-capsule daily formula

• Strong value for a multi-ingredient product
  
  

Cons:

• No third-party test results available

• Absorption may not be optimized for all ingredients

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6. Best High-Potency Fisetin: Toniiq Ultra High Purity Fisetin

If you’re seeking maximum potency, Toniiq Ultra High Purity Fisetin is one of the strongest on the market.

Each capsule provides 500 mg of fisetin standardized to 98% purity, one of the most concentrated forms available. It also includes 100 mg of MCT oil powder, which can help support fat-soluble absorption.

Toniiq is known for rigorous quality control. Every batch is tested in independent labs and produced in GMP-certified facilities.

This supplement is ideal for experienced users who want to elevate their fisetin regimen or for those focusing on targeted senolytic protocols.

Pros:

• Potent 500 mg fisetin dosage

• 98% purity verified by independent testing

• Includes MCT oil for enhanced absorption

• Manufactured in GMP-certified facilities
  
  

Cons:

• High dose may be too strong for beginners

• Does not include synergistic compounds like quercetin
  
  

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7. Best Capsule Quality: HUMANX Fisetin

HUMANX Fisetin focuses on purity, potency, and clean delivery. Each vegan capsule contains 500 mg of 98% pure fisetin derived from Rhus succedanea, encapsulated in plant-based Pullulan capsules, known for their superior protection and stability.

This product is vegan, gluten-free, and soy-free, making it an excellent fit for people with dietary sensitivities or those following plant-based lifestyles. HUMANX is committed to clean formulations with no artificial binders or preservatives.

While it lacks absorption-enhancing ingredients, its ultra-clean profile and consistent dosing make it a premium choice for purity-focused users.

Pros:

• 500 mg of high-purity fisetin per serving

• Made with Pullulan plant capsules

• Free from allergens, soy, and gluten

• 100% vegan-friendly and filler-free
  
  

Cons:

• Higher price per serving

• No added compounds for absorption or synergy
  
  

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What is Fisetin?

You know how we’re told to eat more fruits and vegetables because they’re “full of antioxidants”?Fisetin is one of the hidden gems behind that advice.

Fisetin is a natural compound found in foods like strawberries, apples, grapes, and onions, and it’s quietly gaining attention as one of the most promising anti-aging nutrients of our time.

Why? Because fisetin doesn’t just protect your cells, it helps your body renew them, thereby supporting healthy aging.

As we age, damaged cells known as senescent or “zombie” cells start to build up. They don’t die off as they should; instead, they linger, releasing compounds that accelerate aging and inflammation.

Fisetin helps the body clear out those cells, making room for new, healthy ones to grow.

That’s why many longevity experts consider it a potential breakthrough in graceful aging, cognitive clarity, and cellular resilience (1). 

How Does Fisetin Work?

Many products claim to “fight aging,” but Fisetin is different.  It goes straight to the root cause.

Here’s how it works:

Fisetin works by helping the body remove senescent cells, sometimes called “zombie” cells. These cells stay in the body long after they’ve stopped functioning, which can cause inflammation and damage to surrounding healthy cells. 

Fisetin supports the body’s natural ability to find and clear out these cells. This process is often referred to as a “senolytic” effect. 

Studies have found that senolytic compounds like fisetin may support healthy aging by reducing the overall burden of senescent cells (2). This could lead to improvements in tissue function, energy levels, and resilience as we get older.

Fisetin is also known for its antioxidant effects. That means it helps protect cells from oxidative stress, which can happen when there’s an imbalance between free radicals and antioxidants in the body (3). 

Over time, this type of stress can damage cells and speed up the aging process.

In addition, fisetin appears to influence certain signaling pathways in the brain and other tissues. These pathways are involved in inflammation, cell repair, and even learning and memory. 

While more human studies are needed, early research suggests that fisetin may support both brain function and general cellular health.

Just before you read something else…

You want to maximize the benefits above? The Omre Quercetin + Fisetin formula is one of the smartest ways to do it.

It combines Fisetin (for cellular clean-up) with quercetin phytosome, a high-absorption form that enhances both potency and delivery.

Together, they work to clear senescent cells, reduce inflammation, and promote total body renewal.

• Targets the cellular cause of aging

• Uses Quercetin Phytosome for enhanced absorption

• Clean, filler-free, and third-party tested

• Made in the USA
  
  

Shop Quercetin + Fisetin →
 Your daily cellular rejuvenation formula, made simple.

Potential Health Benefits of Taking Fisetin Supplements

If you’ve ever wished you could feel more energized, think more clearly, or simply age better, Fisetin may help you do all that and even more.

Here’s what current research suggests about its potential benefits:

Anti-aging and lifespan support

Studies have found that fisetin may help reduce the number of senescent cells in the body (4). These old, non-functioning cells are known to build up with age and contribute to inflammation and tissue damage. 

By clearing them out, fisetin could support healthier tissues and potentially help the body age more gracefully. 

In animal studies, fisetin was linked to extended lifespan, but more human research is still needed.

Brain health and cognitive support

Fisetin also shows potential when it comes to brain function. Some studies suggest it may help reduce inflammation in the brain and protect neurons from damage (5). 

This could be helpful for memory, focus, and learning over time. 

Researchers believe fisetin’s antioxidant and anti-inflammatory actions may play a role in protecting the brain from age-related decline.

Supporting balanced cell growth

Although research is still early, some lab studies have looked at how fisetin may help maintain healthy cell division (6). A healthier cellular environment could make it harder for abnormal or fast-growing cells to thrive. 

However, more clinical studies are needed before any strong conclusions can be made.

Heart health and inflammation support

Chronic inflammation is a major risk factor for heart disease. Some studies have found that fisetin may help reduce inflammation in the body, which in turn can support healthier blood vessels and circulation (7). 

While it’s not a replacement for heart medications or other treatments, it may offer some added support for cardiovascular wellness.

What is the Best Way to Take Fisetin?

You can get a little fisetin from foods like strawberries and apples, but here’s the truth, you’d need to eat hundreds of servings daily to match what a single supplement provides.

That’s why supplements are the preferred choice for consistent, meaningful results.

Food Sources of Fisetin:

• Strawberries
  
  

• Apples
  
  

• Grapes
  
  

• Onions
  
  

• Cucumbers
  
  

• Persimmons
  
  

• Mangoes
  
  

• Tomatoes
  
  

Supplement Form

Most fisetin supplements contain 100–500 mg per capsule.
 Because fisetin is fat-soluble, pairing it with a meal containing healthy fats—such as avocado or olive oil—helps your body absorb it better.

If you’re new to fisetin, start on the lower end (100 mg daily) and see how your body responds.

You can increase it gradually or combine it with Quercetin + Fisetin for added synergy and absorption.