5 Best Fisetin Supplements To Buy In 2024: Ranked & Reviewed

Fisetin is a naturally occurring compound found in various fruits and vegetables, especially strawberries. As a senolytic agent, it plays a vital role in clearing out aged, non-functional cells—often referred to as “zombie” cells. These cells can hang around in the body and contribute to inflammation, speeding up the aging process. By encouraging the removal of these senescent cells, fisetin promotes healthier cellular function and supports longevity.

Research suggests that fisetin can significantly reduce the number of these aged cells, which may support tissue health as we get older (1). Studies also indicate that fisetin has neuroprotective qualities, helping to guard brain cells against age-related damage (2). This could be a significant factor in maintaining cognitive health over time.

In addition to its senolytic effects, fisetin is also known for its antioxidant and anti-inflammatory properties. Studies suggest that these effects can help reduce oxidative stress, a major contributor to cellular aging, making fisetin a powerful tool for overall cellular wellness (3). Here’s why it matters:

• Clears out “zombie” cells linked to aging and inflammation.

• Supports brain cell health to potentially protect against cognitive decline.

• Reduces oxidative stress, promoting cellular health across the board.

Fisetin doesn’t just help you feel younger; it helps your cells act younger too.

Top 5 Fisetin Supplements for 2024

Finding a fisetin supplement that meets all your needs can be a game-changer. Here are the top choices for 2024, each bringing unique advantages to the table.

• Omre Quercetin + Fisetin - Best Overall

• GenuinePurity Liposomal Fisetin - Best for Bioavailability

• ProHealth Pure Fisetin - Best Brand Reputability

• Double Wood Fisetin - Best Budget Option

• Clean Nutraceuticals Age Defend - Best Multi-Compound Formula

1. Omre Quercetin + Fisetin - Best Overall

Omre’s Quercetin + Fisetin combines two potent compounds that work together to promote cellular rejuvenation. Each bottle contains a powerful blend of 500mg Quercetin (in phytosome form, making it 20x more absorbable) and 100mg of 98% pure Fisetin. 

This supplement is crafted with an all-natural, filler-free formula and undergoes rigorous third-party testing, ensuring high purity and quality. The senolytic properties of Quercetin and Fisetin can help manage the build-up of senescent “zombie” cells linked to aging.

Key Features:

• 500mg highly absorbable Quercetin (phytosome form)

• 100mg Fisetin at 98% purity

• Third-party tested for purity and contamination

• 30 day ,oney-back guarantee

• Available as a subscription option for savings

Pros:

• High absorption rate with Quercetin phytosome

• Pure, all-natural ingredients with no fillers

• Powerful senolytic action for cellular health

• Easy subscription option at a discount

• Trusted third-party testing

Cons:

• Premium pricing

• Subscription savings only apply with recurring orders

2. GenuinePurity Liposomal Fisetin - Best for Bioavailability

GenuinePurity’s Liposomal Fisetin stands out with its advanced liposomal encapsulation, which enhances the bioavailability of fisetin, making it easier for your body to absorb. This supplement uses 100% certified authentic Fisetin, validated through third-party testing for purity.

It’s also backed by an experienced team with over 20 years in health supplement manufacturing, with each batch made in the USA to meet strict quality standards. GenuinePurity also offers a satisfaction guarantee, allowing you to try it with peace of mind.

Key Features:

• Liposomal encapsulation for better absorption

• 100% certified authentic Fisetin

• cGMP-certified manufacturing in the USA

• 97-day money-back guarantee

• Designed by a team with 20+ years of experience

Pros:

• High bioavailability through liposomal technology

• Certified authentic Fisetin for purity

• Made in the USA following strict manufacturing practices

• Long satisfaction guarantee for peace of mind

• Positive customer reviews on effectiveness

Cons:

• Only available for online purchase

• Higher price due to bioavailability enhancement

3. ProHealth Pure Fisetin - Best Brand Reputability

With over 30 years of experience in the supplement industry, ProHealth’s Pure Fisetin offers reliability and quality. This fisetin is certified authentic and produced in cGMP-certified facilities in the USA. 

Customers praise its effectiveness in supporting longevity and cellular health, and ProHealth backs the supplement with a solid 75-day money-back guarantee. If you’re looking for a well-established brand with a strong reputation, ProHealth Pure Fisetin is an excellent choice.

Key Features:

• Manufactured by a reputable brand with 30+ years of experience

• Certified authentic Fisetin, third-party tested

• cGMP-certified production in the USA

• 75-day money-back guarantee

• Simple, effective formula without extra ingredients

Pros:

• Produced by a trusted, reputable brand

• Certified pure Fisetin for reliable results

• Third-party tested for quality

• Great customer reviews on longevity support

• Long return period for unused portions

Cons:

• No enhanced bioavailability

• Higher price for standard formulation

4. Double Wood Fisetin - Best Budget Option

For those on a budget, Double Wood Fisetin provides a solid option at just $0.34 per serving. It offers 60 days’ worth of fisetin supplementation in each bottle at an affordable price, making it one of the most economical choices. 

Double Wood’s fisetin is third-party tested and manufactured in the USA, ensuring quality even at a lower price. While it lacks bioavailability enhancement, it’s a reliable option for those looking to add fisetin to their routine without overspending.

Key Features:

• Budget-friendly at only $0.34 per serving

• 60 servings per bottle

• Third-party tested for purity

• Manufactured in the USA

• 30-day money-back guarantee

Pros:

• Highly affordable price point

• Third-party tested for quality

• Trusted USA-based manufacturing

• Generous number of servings per bottle

• Simple return policy

Cons:

• Lower fisetin content per serving

• No bioavailability enhancer

5. Clean Nutraceuticals Age Defend - Best Multi-Compound Formula

Clean Nutraceuticals Age Defend combines fisetin with other longevity-supporting compounds like resveratrol and spermidine, which work together to support cellular health. 

Resveratrol is known for its anti-inflammatory properties, while spermidine can help stimulate cellular “cleaning” processes. 

This multi-compound approach offers a broader range of benefits but lacks bioavailability enhancement and third-party testing. Clean Nutraceuticals offers a 180-day satisfaction guarantee, giving you ample time to decide if it’s the right choice for you.

Key Features:

• Includes fisetin, resveratrol, and spermidine

• Supports cellular longevity and healthspan

• 180-day money-back satisfaction guarantee

• Made in the USA

• Targets multiple aging pathways

Pros:

• Broad support for cellular health with multiple ingredients

• Long satisfaction guarantee period

• Manufactured in the USA

• Positive user reviews on effects

• Encourages cellular “cleaning” mechanisms

Cons:

• No third-party testing

• No bioavailability enhancement

What Are the Benefits of Taking Fisetin Supplements?

Adding a fisetin supplement to your wellness routine may offer several valuable health benefits, from slowing down the effects of aging to supporting heart health. Here’s a closer look at what fisetin can do:

Anti-Aging and Lifespan Extension

One of the most promising effects of fisetin is its potential to slow down aging. Studies have shown that fisetin can reduce the presence of senescent cells, leading to healthier tissues and even extended lifespans in animals (4). 

By clearing out these “zombie” cells, fisetin helps slow the signs of aging, making it an attractive option for those looking to maintain vitality and health as they age.

Neuroprotective Properties and Cognitive Support

Fisetin’s brain-protective qualities are another reason for its growing popularity. Research suggests that fisetin can reduce inflammation in the brain, supporting memory and learning functions (5). 

Potential Anti-Cancer Effects

By creating a healthier cellular environment, fisetin may help maintain balanced cell growth and discourage the development of malignant cells.

Cardiovascular Health and Reduced Inflammation

Finally, fisetin may benefit heart health due to its anti-inflammatory properties. Research indicates that lowering inflammation throughout the body can reduce the risk of cardiovascular issues, as chronic inflammation is a significant contributor to heart disease (7). 

By promoting healthy blood flow and reducing inflammation, fisetin could support overall heart function.

What to Consider When Choosing a Fisetin Supplement

When it comes to choosing the best fisetin supplement, paying attention to details like ingredient quality, dosage, and how well the supplement is absorbed can make a big difference.

Purity and Quality of Ingredients

High purity is key when it comes to fisetin. Aim for supplements that offer at least 90% purity, as this ensures a stronger, more effective product. Watch out for fillers or additives, as these can dilute the potency and may introduce unnecessary substances into your supplement. 

A cleaner ingredient profile keeps things simple, ensuring you’re getting pure fisetin without unwanted extras.

Dosage and Potency

Research suggests that effective dosages of fisetin can range from 100mg to 500mg per day, depending on individual goals.

Higher potency supplements tend to deliver better results, as they reach levels where fisetin’s health benefits, like reducing “zombie” cells and supporting cellular function, can really kick in. 

Choosing the right potency will help you achieve the health outcomes you’re after without overdoing it.

Bioavailability and Absorption

Not all fisetin is absorbed equally. Some supplements use delivery mechanisms like liposomal technology to improve absorption, which helps more of the fisetin get into your system. 

Formulations designed for better bioavailability make a real difference because they help your body absorb and use the fisetin more effectively, making each dose count.

Third-Party Testing and Certifications

Third-party testing is a valuable check on quality, helping confirm that what’s on the label matches what’s in the bottle. Look for certifications like GMP compliance, which indicate a reliable manufacturing process. 

These certifications provide some peace of mind that the product has been made with high standards in mind.

How to Take Fisetin for Maximum Benefit

To get the most out of fisetin, the recommended dosage typically varies based on your needs. For general maintenance, around 100mg daily is often enough. 

However, if you’re aiming for more targeted benefits, like supporting cognitive health or reducing cellular aging, dosages up to 500mg may be beneficial.

Taking fisetin with meals, especially those containing healthy fats, can improve its absorption. Since fisetin is fat-soluble, a meal with olive oil, avocado, or yogurt can help your body make better use of each dose. This simple step can maximize the amount your body absorbs and uses.

Pairing fisetin with complementary supplements, like quercetin, may also enhance its effects. Quercetin has similar senolytic properties, and the two can work together to support cellular health. Just be sure to check with a healthcare provider before adding multiple supplements to your routine.

Are There Any Side Effects of Taking Fisetin Supplements?

Fisetin is generally considered safe for most people, but like any supplement, it’s important to stay mindful of any potential side effects. Some individuals may experience mild digestive discomfort, particularly if taken on an empty stomach. Taking it with food often minimizes these minor issues.

Those who are pregnant, breastfeeding, or on medications should be cautious and consult a healthcare provider before using fisetin. Since fisetin can affect cellular processes, it’s wise to get guidance if you have specific health conditions or are taking medication that could interact.

While fisetin’s benefits are promising, it’s always a good idea to approach it with the same care you would with any supplement. Listen to your body and start with a lower dose if you’re new to it.

The Future of Fisetin in Health and Longevity

Ongoing research into fisetin’s health benefits shows a lot of promise. Studies continue to explore its effects on cellular aging and neuroprotection, and there’s growing interest in how fisetin could support longevity. 

This compound’s ability to target “zombie” cells has sparked curiosity in fields related to age-related diseases and lifespan extension.

As researchers dig deeper, fisetin may play a role in therapies designed to slow aging and improve quality of life. Its potential applications range from brain health to joint health, especially for those looking to maintain wellness as they age.

Fisetin’s unique effects on cellular health make it a fascinating area of study, and it’s likely that we’ll be hearing more about its benefits in the years to come.

Conclusion

Wrapping up, fisetin has shown impressive potential for supporting cellular health, cognitive function, and longevity, making it an intriguing addition to a wellness routine. 

With various supplements available, finding the right one comes down to understanding your personal goals and choosing a high-quality product with verified purity and potency. 

From bioavailability enhancements to trusted brands, the options listed here offer something for everyone’s needs.

If you’re ready to explore a top-notch fisetin supplement, consider Omre Quercetin + Fisetin for its unique blend and powerful senolytic benefits. Check availability and give your cells a fresh start today.