9 Best Senolytic Supplements for Healthy Aging (2025)

What Are Senolytic Supplements?

Senolytic supplements are natural or lab-made compounds that help get rid of senescent cells. These are old cells that no longer divide, but they don’t die either. Instead, they stick around and release harmful chemicals that cause low-level inflammation.

Your body normally clears these cells through the immune system. But as we age, that process slows down. Senescent cells build up and start interfering with healthy tissue. That’s part of why we feel more aches, recover slower, and face more age-related issues.

Senolytics work by targeting those worn-out cells and pushing them into a natural cell death process. This may lower inflammation, improve how tissues repair themselves, and support better overall health as you age.

Most senolytic supplements are found in nature, like in fruits, vegetables, herbs, or tea. But in a typical diet, the amounts are often too small to make a big difference. That’s why supplements, when used wisely, can be a useful tool.

9 Best Senolytic Supplements

Some of these are familiar ingredients you’ve likely heard of, but when taken in the right dose and form, they may support your body’s ability to clear out harmful, aging cells.

1. Fisetin

Fisetin is a natural compound found in strawberries, apples, and persimmons. It’s one of the most researched senolytics and has shown strong results in lab tests.

In a 2018 study, fisetin helped reduce senescent cells in mice. The animals not only looked healthier, they also lived longer (1). Fisetin works by encouraging damaged cells to self-destruct, without hurting nearby healthy ones.

It also helps lower inflammation and supports brain function (2). But the amount found in food is tiny. That’s why most experts suggest taking it as a supplement if you want real results.

2. Quercetin

Quercetin is a flavonoid found in apples, onions, and olive oil. It’s known for being a powerful antioxidant, but it also has senolytic effects.

In one study published in EBioMedicine, quercetin helped clear senescent cells when used on its own and worked even better when combined with a drug called dasatinib (3). Some human studies show early signs of benefit, but more research is still underway.

It also supports your heart and may help protect your brain. Quercetin doesn’t absorb well by itself, so many supplements add black pepper extract or use special forms to improve uptake.

3. EGCG (Green Tea Extract)

EGCG is the main active compound in green tea. It’s already known for its anti-inflammatory and antioxidant benefits, but it also has senolytic properties.

Research shows that EGCG can push senescent cells toward natural cell death (4). It also helps your body recycle old cell parts through a process called autophagy. This is important for keeping your tissues working smoothly.

While you can get some EGCG by drinking green tea, supplements offer a higher, more consistent dose. Just be careful with very high amounts, as they can put stress on the liver in sensitive individuals.

4. Curcumin

Curcumin is the compound that gives turmeric its bright yellow color. It doesn’t kill senescent cells directly, but it helps reduce the damage they cause.

It does this by calming down the chemicals those zombie cells release. These chemicals can cause inflammation and harm nearby cells, so curcumin helps create a healthier environment.

Studies also show that curcumin supports brain health, helps reduce joint pain, and may even support metabolic function (5). It’s best taken with black pepper extract to improve absorption.

5. Piperlongumine

Piperlongumine is found in long pepper, a spice used in some traditional remedies. It works by raising oxidative stress inside senescent cells, which makes them self-destruct.

One study published in Scientific Reports showed that piperlongumine reduced the buildup of senescent cells and improved tissue repair in mice (6). That said, human studies are still limited.

Because it increases stress inside cells, using it in high amounts could also affect healthy ones. So it's something to use cautiously and ideally under medical supervision.

6. Oleuropein

Oleuropein comes from olive leaves and is one of the main compounds that give olive oil its health benefits. It’s a strong antioxidant and may help reduce oxidative stress linked to aging.

Some research suggests it supports the natural removal of senescent cells and may help protect tissues like blood vessels and skin from damage (7). It also helps fight inflammation and supports the immune system.

You can get small amounts from olive oil, but supplements can give a more concentrated dose if you're aiming for deeper benefits.

7. Hydroxytyrosol

Hydroxytyrosol is another compound found in olives and olive oil. It works well alongside oleuropein and is one of the most powerful antioxidants found in nature.

It helps protect cells from damage, supports mitochondrial health, and reduces inflammation. By strengthening your cells and lowering oxidative stress, it makes it harder for senescent cells to take over (8).

Supplements with both oleuropein and hydroxytyrosol are often used together to support heart health, cellular repair, and overall longevity.

8. Apigenin

Apigenin is a natural plant compound found in chamomile, parsley, and celery. It isn’t a direct senolytic, but it helps control the bad effects caused by senescent cells.

Instead of killing the cells, apigenin reduces the inflammatory chemicals they release. This can help lower overall inflammation in the body and protect nearby healthy cells from harm.

Studies suggest apigenin also helps defend DNA from oxidative stress and supports cell repair (9). It’s often used to support brain function, reduce anxiety, and may even help the body handle toxins better.

9. Resveratrol

Resveratrol is a polyphenol found in red wine, grapes, berries, and peanuts. It’s been studied for years for its anti-aging and heart-protective effects.

It works by activating sirtuins, which are proteins that help regulate aging and cell survival (10). Resveratrol also reduces inflammation and supports healthy mitochondria, which are your cells’ energy centers.

While it doesn’t directly clear out senescent cells, it supports the cleanup process and helps prevent more from forming. Just keep in mind, very high doses can be hard on the body, so balance matters.

Senolytic Supplements Benefits

Senolytic supplements may help the body deal with aging cells more effectively. While research is still growing, many early findings suggest they can support better overall health as we age.

Here are some of the possible benefits people are looking into:

• May reduce chronic inflammation. These supplements may help clear out senescent cells, which are known to release inflammatory chemicals. This might ease low-level inflammation that builds up as we get older, sometimes called “inflammaging.”

• Supports tissue repair. When inflammation goes down, your body can focus more on healing. That may help with recovery in joints, blood vessels, skin, and other tissues.

• Could improve physical function. Some studies in animals and early human trials suggest that removing zombie cells may help with strength, mobility, and energy levels in older adults.

• May support brain and heart health. Ingredients like fisetin, quercetin, and resveratrol have been linked to better brain function and heart health in lab research. While more studies are needed, early signs look promising.

Side Effects of Senolytic Supplements

Senolytic supplements are usually well tolerated when taken in moderate doses, but like any supplement, they may cause side effects in some people.

Common side effects may include:

• Upset stomach or nausea

• Headaches

• Fatigue

• Mild allergic reactions (especially from plant-based ingredients)

• Interactions with medications (especially blood thinners or anti-inflammatory drugs)

Most of these effects are mild and temporary, but the risk may go up with high doses or when mixing several compounds together. It’s always a good idea to talk with your doctor if you’re unsure or taking any medications.

Quercetin + Fisetin

Quercetin and Fisetin help manage 'zombie' senescent cell burden and support cellular rejuvenation.*

Shop Quercetin + Fisetin

Shop Quercetin + Fisetin

What Foods Are Senolytic?

Many senolytic supplements come from foods we eat every day. These “senolytic foods” contain small amounts of the same compounds used in supplements, but often not in large enough doses to match what’s used in studies.

Still, adding these foods to your diet can be a helpful habit:

• Strawberries and apples – rich in fisetin

• Onions and kale – packed with quercetin

• Green tea – source of EGCG

• Turmeric – contains curcumin

• Chamomile tea – good source of apigenin

• Red grapes and berries – contain resveratrol

• Extra virgin olive oil – has both oleuropein and hydroxytyrosol

These foods aren’t magic, but eating them regularly supports a diet that may help with inflammation and healthy aging over time.

Should You Take Senolytic Supplements?

Senolytic supplements aren’t a one-size-fits-all fix, but they may be helpful for people interested in supporting healthy aging, especially over the age of 40.

If you’re noticing signs of fatigue, slower recovery, joint stiffness, or brain fog, these could be related to the build-up of senescent cells. 

Senolytic supplements might help, but only when used correctly and with good lifestyle habits like sleep, movement, and a healthy diet.

As always, it’s smart to check with a healthcare provider before starting anything new, especially if you’re on medications or dealing with a health condition. Supplements can support the process, but they work best as part of a bigger health plan.

How to Choose the Best Senolytic Supplements

Not all supplements are created equal. If you’re going to take something to support healthy aging, it makes sense to choose a product that actually works. The right senolytic supplement should use high-quality ingredients, be properly dosed, and ideally have some scientific backing.

Here are a few things to look for:

• Purity and transparency: Check if the ingredients are 98% or higher in purity and clearly listed on the label.

• Research-backed dosages:  Look for products that match the doses used in clinical or lab studies, not just trace amounts.

• Synergistic combinations:  Some senolytics work better when combined, like Quercetin and Fisetin.

• Absorption: Ingredients like quercetin and resveratrol are hard to absorb, so look for forms that include piperine or other absorption boosters.

• No fillers or hidden ingredients: You want active compounds, not fluff.

• 3rd-party testing: Products should be tested for purity, potency, and safety.

If you're looking for a simple, powerful option to support your cellular health, one great combo is Quercetin + Fisetin. Another solid choice is NMN + Resveratrol, especially if you're focusing on NAD+ support and energy production.

These combinations don’t just sound good on paper; they’re backed by research and designed for real results. 

Quercetin and Fisetin work together to help your body clear out aging cells, while NMN and Resveratrol support your energy levels at the cellular level. Each one tackles a different part of the aging puzzle.

The best part is, you don’t need a dozen different bottles to make it work. Both of these products give you a high-quality blend in just a couple of capsules a day, with no junk or unnecessary extras. It's a practical way to support your health without overcomplicating your routine.

Conclusion

Senolytic supplements are gaining attention for a reason. They support the body’s natural process of clearing out old, damaged cells that build up with age. 

By helping to reduce inflammation and support cellular repair, these supplements may play a role in healthier aging. Natural compounds like fisetin, quercetin, EGCG, and resveratrol all show potential when taken in the right form and dosage.

Looking for a trusted option? Check our longevity collection to find clean, effective formulas designed to support your health at the cellular level.

FAQs

What are senolytic supplements used for?

They’re taken to help remove senescent or “zombie” cells, which may reduce inflammation and support healthier aging.

Do senolytic supplements work?

Some early studies in animals and humans show positive results. Compounds like fisetin and quercetin are especially promising, but more research is still being done.

Can I get senolytics from food?

Yes, many senolytics come from foods like strawberries, apples, onions, and green tea. But the amounts are small, so supplements are often used for stronger effects.

Is it safe to take multiple senolytic supplements?

Some combinations, like quercetin and fisetin, work well together. Still, it’s best to start with one product and talk to a healthcare provider if you’re planning to stack them.