9 Best Mitochondria Supplements for Energy, Aging & Cellular Health (2025)

Why Mitochondrial Health Matters

Mitochondria are tiny parts inside your cells that work like power plants. They take the food you eat and turn it into energy your body can use. Every heartbeat, every thought, every movement—you need your mitochondria for all of it.

But as we get older, these little energy producers don’t work as well. They slow down, get damaged, or even stop working. This can lead to lower energy levels, more fatigue, slower recovery, and even some health problems.

Things like stress, poor diet, lack of sleep, and toxins can make it worse. The result? You feel tired, your brain doesn’t feel as sharp, and your muscles may not work like they used to. Scientists even link this decline to the aging process itself.

The good news is that you can support your mitochondria through better lifestyle choices and high-quality mitochondrial health supplements. The ones listed below can help protect your mitochondria, clean up the damaged ones, or even help your body make new ones.

Top Mitochondria Supplements People Trust in 2025

If you’ve been feeling low on energy or simply want to support healthy aging, these are some of the best mitochondria supplements people are using in 2025. Do not worry, they are all backed by growing research and real results. 

Each of these mitochondrial support supplements helps your cells in a unique way:
some recharge your body’s energy production, others protect against cellular damage, and a few even help your body create new mitochondria so your system runs stronger for longer. 

These mitochondria supplements:

1. NMN – Replenishes NAD+ for youthful cellular energy

2. Urolithin A – Cleans out old, weak mitochondria so new ones can thrive

3. CoQ10 – Powers up heart and muscle energy production

4. Alpha-Lipoic Acid (ALA) – Defends cells against oxidative stress

5. PQQ – Encourages your body to build brand-new mitochondria

6. Calcium Alpha-Ketoglutarate (Ca-AKG) – Supports metabolism and longevity

7. Acetyl-L-Carnitine (ALCAR) – Sharpens focus and brain energy

8. Creatine – Boosts strength, recovery, and quick energy cycles

9. Resveratrol – Activates longevity genes and reduces inflammation

9 Best Supplements to Support Mitochondrial Function

Some supplements are especially effective at helping your mitochondria work better.
Walk with us as we analyze the best 9.

1. NMN (Nicotinamide Mononucleotide)

Best for: Longevity & Daily Cellular EnergyNMN is a molecule your body uses to make NAD+, which is essential for energy production inside your cells. NAD+ also helps with DNA repair and supports healthy aging. 

As we get older, our natural NAD+ levels drop. That can slow down how well our mitochondria function and affect how much energy our cells can make.

Studies have shown that taking NMN can raise NAD+ levels and improve mitochondrial activity (1). In one human trial, older adults who took NMN daily saw improvements in muscle performance and metabolism (2). 

Animal studies have also reported better endurance and improved insulin sensitivity (3).

People often take NMN in doses ranging from 250 to 500 milligrams per day. It's usually taken in the morning because that's when NAD+ production is naturally higher.

If you're considering NMN, it’s worth choosing a product with good bioavailability since absorption can vary.

Research-backed benefits:

• Boosts NAD+ levels for stronger mitochondrial function.

• Supports DNA repair, metabolism, and healthy aging.

• Improves muscle endurance and insulin sensitivity in both human and animal studies.
  
  

Typical dosage: 250–500 mg daily, taken in the morning for optimal absorption.

If you’re new to NMN, start with OMRE NMN + Resveratrol, a pure, research-backed combo for steady energy and cellular rejuvenation.

2. Urolithin A

Best for: Cellular Renewal (Mitophagy)

Urolithin A is a compound that supports mitophagy, the process your body uses to clean out old and damaged mitochondria. This recycling helps keep your cells running efficiently.

Normally, your gut makes Urolithin A after digesting foods like pomegranates or berries, but not everyone produces enough due to differences in gut bacteria. Supplementing with Urolithin A has been shown to improve how mitochondria function. 

In one study, older adults who took it for four months had better muscle endurance without changing their exercise routine (4). Researchers have also found that it helps cells maintain structure and energy output as they age (5).

Most supplements provide between 500 and 1,000 milligrams per day. It’s usually taken with food for better absorption. Since natural production in the gut can vary, a supplement is often the most reliable way to get it.

What studies show:

• Enhances mitochondrial quality and endurance in older adults.
• Improves muscle performance even without increased exercise.
• Helps cells maintain structure and energy balance.
  
  

Typical dosage: 500–1,000 mg daily with food.

3. Coenzyme Q10 (CoQ10)

Best for: Heart Health & Energy Endurance

CoQ10 is found in every cell of your body, especially in organs that use a lot of energy like your heart and muscles. It plays a central role in the mitochondria, helping move electrons through the chain that produces ATP, the energy your body needs to function.

Your natural levels of CoQ10 decrease with age and can also drop if you’re taking certain medications like statins. This decline can make energy production less efficient and increase oxidative stress, which damages cells. 

Several studies have found that supplementing with CoQ10 can improve energy metabolism, reduce fatigue, and support cardiovascular health (6).

The typical daily dose is between 100 and 300 milligrams. CoQ10 works best when taken with food that contains fat, as this helps absorption. 

There are two forms: ubiquinone and ubiquinol. While both are effective, ubiquinol is usually better absorbed, especially in older adults.

Proven benefits:

• Restores energy production and reduces fatigue.

• Protects heart and brain from oxidative damage.

• Supports cardiovascular performance and recovery.

Typical dosage: 100–300 mg daily with a meal that contains fat.
 For best results, choose the ubiquinol form; it’s more bioavailable, especially for older adults.  

You can combine CoQ10 with OMRE NMN + Resveratrol to strengthen both your ATP and NAD+ energy systems naturally.

4. Alpha-Lipoic Acid (ALA)

Best for: Antioxidant Protection & Nerve Support

Alpha-lipoic acid is a powerful antioxidant that helps your cells manage oxidative stress, which can damage mitochondria over time. 

It’s unique because it works in both water and fat, allowing it to reach deep into cells where it can neutralize harmful free radicals. It also helps regenerate other antioxidants like vitamin C and glutathione.

Research has shown that ALA is one of the supplements to help mitochondria function better, especially in the brain and nervous system (7). 

A study reported that ALA improved energy metabolism and reduced signs of oxidative damage in older adults. It may also support blood sugar balance, which has its own link to healthier mitochondria (8).

The typical dose ranges from 300 to 600 milligrams per day. It’s available in two forms: regular ALA and R-lipoic acid (R-ALA), the natural form your body uses more easily. R-ALA tends to be more expensive but is absorbed better.

Research insights:

• Improves mitochondrial energy metabolism.

• Reduces oxidative stress in aging populations.

• May support blood sugar balance and brain health.
  
  

Dosage: 300–600 mg per day, with R-ALA being the more bioavailable form.

ALA complements NMN beautifully; while NMN fuels your mitochondria, ALA shields them from damage. (Discover more)

5. Pyrroloquinoline Quinone (PQQ)

Best for: Creating New Mitochondria (Biogenesis)

PQQ is a nutrient that helps trigger mitochondrial biogenesis, which means your body starts producing new mitochondria. This process naturally slows down with age, but PQQ can help reactivate it by signaling certain pathways in your cells, like PGC-1α.

Several studies have found that PQQ not only helps increase the number of mitochondria but also supports their function and stability. It has also been shown to reduce inflammation and support cognitive performance, especially under stress (9). 

In animal studies, PQQ helped preserve mitochondria in brain tissue and may help with memory and focus (10).

Common doses range from 10 to 20 milligrams per day. It’s usually taken with meals to improve absorption. Some people also combine it with CoQ10 or NMN for broader mitochondrial support.

Clinical findings:

• Increases mitochondrial density and function.

• Supports cognitive performance and focus under stress.

• Reduces inflammation and oxidative damage.

Typical dosage: 10–20 mg daily with meals.

Stack PQQ with CoQ10 for double the mitochondrial support. One builds new energy factories; the other keeps them running smoothly. (Begin Here)

6. Calcium Alpha-Ketoglutarate (Ca-AKG)

Best for: Longevity, DNA Repair & Metabolism

Calcium alpha-ketoglutarate is involved in the Krebs cycle, the process your mitochondria use to convert food into energy. 

It also helps reduce oxidative stress by lowering the production of reactive oxygen species, which are byproducts of energy production that can damage cells if not kept in check.

Recent research has suggested that Ca-AKG may support healthier aging by improving how mitochondria function (11). In lab studies, it has been linked to better cell repair, stronger metabolism, and even longer lifespan in some animal models (12). 

It also helps with collagen production and DNA maintenance, both of which decline with age.

A common dose is around 1,000 milligrams per day. Many people take it in the morning to align with natural energy cycles. While research in humans is still growing, early findings are promising for its role in energy support and longevity.

Emerging research shows:

• Supports collagen synthesis and DNA repair.

• Promotes healthy metabolism and mitochondrial balance.

• May extend lifespan in some animal models.
  
  

Dosage: Around 1,000 mg daily, ideally in the morning for alignment with your body’s natural energy cycle.

For a complete longevity routine, try stacking Ca-AKG with NMN and resveratrol—your body’s best trio for energy and youthfulness. (Shop Now)

7. Acetyl-L-Carnitine (ALCAR)

Best for: Brain Energy, Focus & Mood Support

If you often feel mentally drained or struggle with focus, Acetyl-L-Carnitine might be your secret weapon.
 It’s a form of carnitine that helps transport fatty acids into your mitochondria, where they’re converted into clean, long-lasting energy.

This process becomes especially important during exercise or whenever your body relies more on fat for fuel.
 Unlike regular carnitine, ALCAR also crosses the blood-brain barrier, meaning it can power up your brain cells, sharpen focus, and support a balanced mood.

Benefits supported by studies:

• Improves mitochondrial function in both muscle and brain cells.

• Stabilizes cell membranes and supports production of key compounds like cardiolipin, vital for mitochondrial structure (13).

• Reduces oxidative stress while enhancing mood, mental clarity, and cognitive resilience in aging adults.
  
  

Typical dosage: 1,500–3,000 mg daily, split into two servings (morning and early afternoon) to sustain energy without affecting sleep.

What research shows:

• Enhances mitochondrial efficiency in the brain and muscles.

• Reduces oxidative stress and supports neurotransmitter function.

• May improve mood, memory, and clarity with consistent use.
  
  

Typical dosage: 1,500–3,000 mg daily, split between morning and afternoon doses.

If brain fog or fatigue is your struggle, ALCAR plus NMN can help recharge your mental energy from within. (Discover more)

8. Creatine

Best for: Cellular Power & Physical Performance

Best for: Cellular Power, Recovery & Brain Support

Most people think of creatine as just a muscle-building supplement, but its real power goes far deeper.

Creatine plays a crucial role in maintaining and recycling ATP, the molecule your mitochondria produce to fuel every movement, thought, and heartbeat.

When your cells need quick energy during a workout, a stressful day, or intense mental focus, creatine steps in to refill your energy reserves instantly.

What the research shows:

• Helps stabilize mitochondrial function during physical and mental stress (14).
  
  

• Supports brain health, memory, and focus by improving energy efficiency.
  
  

• Enhances strength, endurance, and recovery in muscle cells by making ATP production more effective (15).
  
  

Typical dosage: 3–5 grams per day. Some people use a short “loading phase” of about 20 grams per day for one week, but it’s optional. It mixes easily with water or a smoothie and absorbs best when taken with a small amount of carbohydrate.

Dosage: 3–5 grams daily (loading phase optional).

For all-day stamina, pair creatine with mitochondrial boosters like CoQ10 or NMN, a combination that powers both your muscles and your mind. (Shop Now)

9. Resveratrol

Best for: Healthy Aging, Longevity & Mitochondrial Defense

So you’re serious about aging well, looking sharper, thinking clearer, and feeling stronger for longer? Resveratrol deserves a spot in your routine.

This powerful plant compound, found in red grapes, berries, and peanuts, activates sirtuins, the “longevity proteins” that control how efficiently your mitochondria repair, recover, and adapt to stress.

When sirtuins are active, your cells handle stress better, use energy more efficiently, and stay younger on the inside.

What research shows:

• Supports mitochondrial biogenesis, helping your body create new mitochondria for sustained energy and resilience.

• Reduces oxidative damage and inflammation that accelerate aging.

• Improves metabolic balance and longevity markers in multiple studies (17).
  
  

Typical dosage: 250–500 mg per day, ideally with a fat-containing meal for better absorption (since it’s fat-soluble).

For best results, choose a supplement that combines resveratrol with NAD+ precursors like NMN for complete cellular support.

That’s exactly what OMRE NMN + Resveratrol does. It blends these two powerhouse ingredients for total energy, focus, and longevity in one daily dose.

NMN + RESVERATROL

Cellular NAD+ booster with ultra‑pure NMN and Resveratrol, at research‑backed doses.*

Shop NMN + RESVERATROL

Shop NMN + RESVERATROL

Is It Safe to Take Mitochondria Supplements?

Mitochondria supplements are generally considered safe for most healthy adults, especially when taken in clinically recommended amounts.

They’re formulated from compounds that naturally exist in your body or are found in everyday foods such as amino acids, vitamins, and plant extracts.

When used correctly, these supplements support energy metabolism and cellular repair without disrupting your body’s natural balance.

Here’s what to keep in mind for safety:

• Choose third-party tested brands to ensure purity and potency.

• Verify that the ingredients are at least 95% pure and used in research-backed doses.

• Avoid cheap fillers or artificial additives that may interfere with absorption.

• Store in a cool, dry place away from sunlight to preserve quality.
  
  

If you’re pregnant, nursing, taking prescription medication, or managing a medical condition, it’s always best to consult your doctor before starting any new supplement routine.

High-quality, clinically tested formulas like OMRE NMN + Resveratrol are designed for safety, purity, and consistent results, so you can focus on feeling better, not worrying about what’s in your bottle. (Get it Now)

Are There Any Side Effects?

Most people tolerate mitochondrial supplements very well, especially when starting with proper doses.

However, as your body adjusts, you may experience mild and temporary effects such as:

• Slight nausea or stomach discomfort (if taken on an empty stomach)

• Mild headaches (often from increased energy turnover)

• Restlessness or sleep disturbance (if taken too late in the day)

These are usually short-lived and can be minimized by:

• Taking supplements with meals

• Drinking enough water throughout the day

• Starting with a lower dose and gradually increasing
  
  

If side effects persist, it’s best to pause for a few days and speak with your healthcare provider.

Morning dosing is often ideal, especially for energy-boosting nutrients like NMN and ALCAR, which naturally align with your body’s circadian rhythm.

What to Look for in a Mitochondria Supplement

Not all supplements are created equal, and the quality of what you choose directly affects your results.

When shopping for a mitochondrial formula, here’s what matters most:

Ingredient Purity: Look for ingredients that are at least 95% pure. Lower-grade options may not deliver the intended cellular benefits.

Research-Backed Dosages: Check that each serving matches dosages used in clinical studies;  avoid vague “proprietary blends.”

No Fillers or Artificial Additives: Pure formulas absorb better and reduce the risk of digestive upset.

Third-Party Testing: Reputable brands verify potency and purity through independent lab testing.

Transparent Labeling: You should see exact ingredient quantities listed; transparency builds trust.

If you’re looking for a clinically clean, high-purity option that supports mitochondrial energy and healthy aging,

OMRE NMN + Resveratrol stands out for its dual-action formula, combining 500 mg of pure NMN with Resveratrol and BioPerine® for enhanced absorption.

Formulated in a GMP-certified facility, third-party tested, and free from fillers, OMRE is a supplement you can take daily with confidence.

Lifestyle Tips to Support Mitochondrial Health Naturally

Supplements can help, but how you live day to day also plays a big role in how well your mitochondria function. Here are some practical lifestyle tips that can make a real difference:

• Move regularly. Exercise helps your body make new mitochondria and improves the ones you already have. Walking, strength training, and interval workouts are all helpful.

• Get good sleep. Deep, restful sleep gives your cells time to repair. Aim for 7 to 8 hours of consistent sleep every night.

• Eat real food. A diet rich in whole foods, healthy fats, leafy greens, and berries supports mitochondrial function. Avoiding ultra-processed food also helps.

• Manage stress. Chronic stress wears out your mitochondria. Breathing exercises, quiet time, and nature walks help your body recover.

• Limit toxins. Smoking, air pollution, and even too much alcohol can damage mitochondria. Reducing exposure where you can makes a difference.

• Stay cool and get sunlight. Cold exposure (like cold showers) and short sun breaks can improve mitochondrial efficiency when done safely.

Just before you go…

Your mitochondria quietly power everything you do, starting from your first thought in the morning to your last burst of energy at night.

When they perform well, you perform well with sharper focus, steadier energy, and slower signs of aging.

Scientific research continues to confirm it: ingredients like NMN, CoQ10, Urolithin A, and Resveratrol can make a real difference in how efficiently your cells produce energy, repair damage, and defend against oxidative stress.

Of course, supplements work best alongside good habits, consistent movement, quality sleep, whole foods, and stress management. But if you’re ready to give your cells an edge, adding the right mitochondrial support can elevate your energy and longevity to a whole new level.

Start simple. Start strong.
OMRE NMN + Resveratrol combines two of the most researched, synergistic ingredients for cellular energy and healthy aging: pure NMN to boost NAD+ and Resveratrol to activate your longevity genes.

Formulated with BioPerine® for absorption and backed by third-party testing, it’s a formula built for clarity, vitality, and confidence you can feel every day.

Rebuild your energy from within. Try OMRE NMN + Resveratrol and experience what better cellular health feels like.

FAQs

Can you take multiple mitochondrial supplements together?

Many of these supplements work well together because they target different areas of mitochondrial function. For example, NMN supports NAD+ production, while CoQ10 supports ATP production. Just avoid doubling up on similar ingredients unless recommended by a healthcare provider.

How long does it take to see results?

Some people notice improved energy or mental clarity within a few weeks, but it often takes 6 to 8 weeks of consistent use for more noticeable changes. Everyone responds a bit differently depending on age, lifestyle, and current health.

Are these supplements safe long-term?

When used at recommended doses and sourced from reputable brands, most mitochondrial supplements are safe for long-term use. Still, it's a good idea to review your routine with a healthcare provider once in a while, especially if you’re taking medications.

Do I still need to exercise and eat well?

Yes. Supplements support your mitochondria, but they don't replace good habits. Daily movement, sleep, stress management, and a real-food diet still do most of the heavy lifting when it comes to energy and longevity.

Can mitochondrial supplements help with brain fog or fatigue?

They might. Several ingredients like ALCAR, NMN, and creatine have been studied for their impact on mental clarity and energy. While not a cure-all, they may support better focus and stamina when used consistently.