Liposomal NAD+ vs NMN: Which Supplement Boosts Energy and Longevity Better?
Updated on Feb 23, 2026
Medically reviewed by Dr Pedram Kordrostami— Written by Dr. Dominic Gartry M.D.
Updated on Feb 23, 2026
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If you’re looking to stay energized and keep your body feeling youthful, you’ve probably heard of NAD+ and NMN supplements.
These are two heavy hitters when it comes to supporting cellular health.
Now, with liposomal NAD+ entering the market, there’s a buzz about whether this advanced delivery system can outshine regular NMN.
Is it worth the hype, or are we better off sticking to the basics?
Let’s unpack the details and see which one truly delivers on its promises.
What Are NAD+ and NMN?
Both NAD+ and NMN are essential players in cellular energy and repair, but they operate in slightly different ways. Understanding their roles can help you decide which supplement fits your needs better.
What is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell, responsible for converting food into energy and aiding in essential cellular functions like DNA repair and metabolism.
Think of NAD+ as the fuel that keeps your cells running smoothly. Without it, your body struggles to turn food into usable energy, leaving you feeling sluggish and drained. On top of that, NAD+ helps repair damaged DNA and supports metabolic health.
The tricky part? NAD+ levels naturally decline as you age. This drop is linked to slower recovery, fatigue, and even some age-related diseases. Supplementing with NAD+ or its precursors has become a popular way to counter this decline and promote healthier aging.
It’s important to note that NAD+ doesn’t just boost energy—it plays a central role in many processes that keep your body functioning at its best. From supporting your immune system to keeping your brain sharp, NAD+ is a multi-tasker that deserves attention.
What is NMN?
NMN (Nicotinamide Mononucleotide) is a molecule that acts as a precursor to NAD+, helping to restore declining levels and support cellular energy and repair.
If NAD+ is the fuel, NMN is like the raw material used to create it. NMN is converted into NAD+ once it enters your body, making it a practical way to replenish those dwindling NAD+ levels naturally.
Why not just take NAD+ directly? The body has a hard time absorbing NAD+ in its pure form, while NMN is more easily taken up and processed, thanks to specialized transporters in cells.
Studies suggest that NMN supplementation can improve physical performance, enhance DNA repair, and support cognitive health—all by increasing NAD+ levels (1).
It’s also naturally found in foods like broccoli and avocado, but the amounts are too small to make a significant impact without supplements.
So, if you’re looking to give your cells the tools they need to function optimally as you age, NMN is a well-researched and effective option.
What is Liposomal Delivery and How Does It Work?
About the medical reviewer
Dr Pedram Kordrostami
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