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If you’re searching for a pure NAD supplement to support energy, focus, or healthy aging, you’re not alone.
But not all supplements are made the same. A pure NAD supplement means you’re getting a clean, concentrated formula—without unnecessary fillers—backed by science and trusted testing.
In this guide, we’ve handpicked 9 of the best pure NAD supplements in 2025.
Each one has been carefully reviewed based on quality, ingredients, clinical support, and real user results—so you can feel confident choosing what’s right for your health.
Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*
NMN + RESVERATROL
Best Pure NAD Supplements: Our Top Picks
Best Overall: Omre NMN + Resveratrol
Best Clinically Proven NR: Tru Niagen
Best Dual-Action Formula: Elysium Basis
Best High-Dose NMN Powder: ProHealth NMN Pro Powder
Best Budget NMN Capsules: Genex NMN Capsules
Best for Absorption: Quicksilver Scientific NAD+ Gold
Best Sublingual NR Powder: Renue By Science NR Powder
Best Sport-Certified NR: Thorne NiaCel 400
Best Value NR Option: Life Extension NAD+ Cell Regenerator
1. Best Overall: Omre NMN + Resveratrol
Omre’s formula stands out for its clean, research-based approach to NAD+ support. It combines 500 mg of ultra-pure NMN with 500 mg of Resveratrol—two compounds widely studied for their potential role in cellular health and aging.
The addition of BioPerine®, a black pepper extract, is a smart move to enhance Resveratrol absorption, which tends to be low on its own.
Each bottle provides a 30-day supply and is priced around $59.97, which offers solid value considering the purity (99% NMN, 98% Resveratrol), third-party testing, and GMP-certified production. You’ll need to take it with a bit of dietary fat for best results, but that’s a small ask for what you get.
Pros:
High-purity NMN and Resveratrol
Enhanced absorption with BioPerine®
GMP-certified and third-party tested
Well-balanced, research-backed dosing
Cons:
Requires fat intake for optimal results
Capsule form may not suit everyone
2. Best Clinically Proven NR: Tru Niagen
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Tru Niagen uses a patented form of nicotinamide riboside (NR), backed by strong human research. In clinical studies, NR has been shown to boost NAD+ levels by more than 50% within just two weeks.
It’s also FDA GRAS-certified and manufactured in NSF-certified facilities, which boosts trust in its safety and quality.
Each 30-day bottle, priced at around $47.50, delivers 300 mg of NR per capsule. It’s a straightforward, well-tested option—especially for those who want a pure NAD supplement with minimal additives.
Pros:
Clinically shown to boost NAD+ by 50%+
FDA GRAS-certified
Simple, clean formula
Third-party tested
Cons:
May require higher doses for some users
Doesn’t include synergistic ingredients
3. Best Dual-Action Formula: Elysium Basis
Elysium combines 250 mg of NR with 50 mg of pterostilbene, a potent antioxidant that may help combat oxidative stress. This dual-action approach supports both NAD+ production and cellular protection, making it appealing for long-term use.
It’s NSF Certified for Sport and backed by a clinical study showing a 40% NAD+ increase. At about $54 for a 30-day supply, it strikes a balance between scientific support and added value from its antioxidant content.
Pros:
Includes antioxidant pterostilbene
Backed by clinical data (40% NAD+ increase)
NSF Certified for Sport
Suitable for long-term cellular support
Cons:
NR dose may be low for some users
Slightly higher price for the amount of NR
4. Best High-Dose NMN Powder: ProHealth NMN Pro Powder
This powder offers a high-strength dose of NMN—1,000 mg per serving—in sublingual form for better absorption. It’s manufactured in a GMP-certified facility, rigorously third-party tested, and solvent-free.
Ideal for those who prefer a customizable approach, it costs around $79.80 for a 30-serving tub. It requires a bit more effort to take compared to capsules, but the dose and delivery make it worthwhile for advanced users.
Pros:
High-dose NMN (1,000 mg per serving)
Sublingual format for faster absorption
Solvent-free and lab-tested
Customizable dosage
Cons:
Powder may be less convenient than capsules
Higher price than lower-dose options
5. Best Budget NMN Capsules: Genex NMN Capsules
Genex provides an accessible entry point to NMN supplementation. Each capsule contains 250 mg of NMN and is third-party tested for safety and purity. It’s a solid starter option for those curious about NAD+ boosting.
At $29.99 for 60 capsules, it’s one of the most affordable choices on the market. Those needing higher doses may need to take more capsules daily, but the cost makes it manageable.
Pros:
Great price for beginners
250 mg dose per capsule
Clean, tested formula
Easy to scale up dosing
Cons:
May require multiple capsules for full effect
No added synergistic ingredients
6. Best for Absorption: Quicksilver Scientific NAD+ Gold
This supplement uses a liposomal liquid delivery system with 50 mg of NMN per 1 mL serving, along with TMG to support methylation. The format allows for quick absorption through the mouth, which may benefit users sensitive to capsules.
A bottle costs about $68.50 for 50 servings, offering good flexibility in dosing. The low dose might not be sufficient for everyone, but the efficient delivery makes it effective for many.
Pros:
Liposomal delivery improves absorption
Includes TMG for methylation support
Liquid format is convenient for travel
Flexible, easy dosing
Cons:
Low NMN dose per serving
More expensive per mg than capsules
7. Best Sublingual NR Powder: Renue By Science NR Powder
Renue’s sublingual NR powder provides a potent 1,000 mg dose per serving, designed for faster absorption directly through oral tissues. The brand is known for rigorous testing and high-quality standards.
At $109 for a 60-serving tub, it’s on the premium side, but the higher absorption rate and adjustability make it a strong contender for those who want efficient NAD+ support.
Pros:
High dose of NR (1,000 mg)
Sublingual form for faster delivery
Trusted, transparent brand
Flavored for easier use
Cons:
Higher cost than capsule options
Powder form may not suit all preferences
8. Best Sport-Certified NR: Thorne NiaCel 400
Thorne’s NiaCel 400 includes 415 mg of NR along with betaine (TMG), offering strong support for energy metabolism and healthy aging. The NSF Certified for Sport label ensures it's safe for athletes and tested for banned substances.
A bottle costs around $67.62 for 30 servings, which reflects its premium manufacturing and quality assurance. It doesn’t include antioxidants, but the formulation is solid for NAD+ and cellular support.
Pros:
High-dose NR with TMG
NSF Certified for Sport
Well-respected brand
Clean, professional-grade manufacturing
Cons:
Doesn’t include antioxidants like Resveratrol
Higher price than basic NR supplements
9. Best Value NR Option: Life Extension NAD+ Cell Regenerator
This supplement provides 300 mg of NIAGEN® (a patented NR) per vegetarian capsule. It’s clean, third-party tested, and produced by a trusted name in supplements.
At $36.45 for a month’s supply, it’s an affordable and reliable way to support NAD+ levels without breaking the bank. It doesn’t include other ingredients, but that simplicity can be a plus for new users.
Pros:
Affordable and beginner-friendly
300 mg of patented NR per capsule
Non-GMO and vegetarian
Long-standing brand with good reputation
Cons:
No extra ingredients for enhanced effects
Moderate dose compared to others
How We Selected These Pure NAD Supplements
We didn’t just pick random products off the shelf. Each pure NAD supplement on this list was chosen based on quality, transparency, and scientific support. Our goal was to highlight clean, effective options that are safe and actually do what they claim.
First, we focused on formulas that use well-researched NAD+ precursors like NMN and NR. These are the most studied ingredients for naturally increasing NAD+ levels, and we prioritized brands that clearly list dosages and avoid hidden blends.
We also checked for third-party testing and GMP-certified manufacturing. These are key signs of product safety and purity—especially important when it comes to long-term daily use.
Finally, we reviewed clinical data, expert opinions, and real customer feedback. We looked for consistent results in areas like energy, focus, and aging support, and balanced this with overall value for the price.
What is NAD+?
NAD+ (short for Nicotinamide Adenine Dinucleotide) is a tiny molecule that plays a big role in how your body works. It’s found in every single cell and helps turn the food you eat into energy. It also helps repair damaged DNA, keep your cells healthy, and support your body’s natural defenses.
One of its biggest jobs is helping your mitochondria—often called the “batteries” of your cells—do their thing. When NAD+ levels are high, your cells can create energy efficiently, repair themselves better, and deal with stress more easily.
But as we age, our NAD+ levels naturally go down. That drop can affect how we feel and function. A well-known study published in Nature Reviews Molecular Cell Biology pointed out that this decline in NAD+ is closely linked to aging, lower energy, and a greater risk of age-related issues (1).
According to Dr. Christopher Martens, a researcher studying aging and NAD at the University of Delaware, “NAD is involved in hundreds of reactions in the body, especially those tied to energy and repair.” He explains that when NAD+ levels drop, your body might start feeling more tired, and your cells may not work as well as they used to.
Things like stress, poor sleep, or even a not-so-great diet can lower NAD+ even more. That’s why many people look into supplements—to help bring those levels back up and support their overall health.
So, while your body does make NAD+ on its own, using a supplement—especially a pure NAD supplement—might help give your cells the extra boost they need as you get older.
Why Take a Pure NAD Supplement?
As we get older, our bodies start to make less NAD+. This slow decline might not be something you feel right away, but over time it can affect your energy, how fast you recover, and even how clearly you think.
That’s where a pure NAD supplement comes in. These supplements are made to help bring your NAD+ levels back up, which may support better energy, sharper focus, and healthier aging.
Researchers have found that boosting NAD+ levels might help in a few key areas:
Energy Support: NAD+ plays a big role in how your cells turn food into energy. When your levels drop, it can leave you feeling drained. According to Dr. Rishi Mandavia, “NAD helps your body make ATP, which is like fuel for your cells.”
Cellular Health: In a 2022 review published in Frontiers in Aging, scientists noted that raising NAD+ levels may support DNA repair and help cells stay healthy as we age (2).
Brain Function: Some early studies suggest NAD+ precursors like NMN and NR may improve focus and memory (3). In animal research, they’ve been shown to boost cognitive performance, and human studies are now starting to explore similar results (4).
Aging Gracefully: Dr. Amanda Kahn, a longevity researcher, explains it simply: “If NAD+ is going down as we age, it makes sense to look at ways to bring it back up.” While she cautions that supplements aren’t a cure-all, there’s growing evidence that supporting your NAD+ levels might help you age in a healthier way.
Of course, it’s important to keep expectations realistic. These supplements won’t make you feel 20 again overnight. But over time, many users report more steady energy, better sleep, and improved recovery from workouts.
And if you’re taking a pure NAD supplement—one that avoids fillers and uses clean, research-backed ingredients—you’re giving your body what it needs without unnecessary extras.
Types of NAD Supplements
Not all NAD supplements are the same. Some give you NAD+ directly, while others help your body make it using something called precursors. Knowing the difference can help you choose the one that fits your needs best.
1. Pure NAD+
Some supplements try to give you NAD+ in its full, ready-made form. While that might sound like the quickest way to boost your levels, it doesn’t really work that well.
NAD+ is a large molecule, and research shows that our bodies can’t absorb it efficiently—not even through IV drips.
In fact, studies have found that NAD+ IV therapy doesn’t live up to the hype. Because the molecule is too big, it struggles to enter cells where it's actually needed (5).
That’s why most experts recommend using NAD+ precursors like NMN or NR instead—your body can absorb and convert these much more easily.
2. Nicotinamide Riboside (NR)
NR is one of the most well-researched NAD+ precursors. It’s a form of vitamin B3, and once inside your body, it helps create NAD+ through a multi-step process.
One study published in Nature Communications found that NR supplements raised NAD+ levels by about 60% after just three weeks (5). Tru Niagen, one of the most popular NR brands, has also been through multiple human trials and has been granted “Generally Recognized As Safe” status by the FDA.
NR is usually taken in capsule form and is known for being stable, safe, and easy to fit into a daily routine.
3. Nicotinamide Mononucleotide (NMN)
NMN is another top choice and is actually one step closer to NAD+ than NR. For a long time, scientists believed NMN couldn’t be absorbed directly by cells—but that changed in 2019, when researchers discovered a special transporter in the gut (called Slc12a8) that helps NMN get into the cells quickly, especially in older individuals.
Because of this, many experts now see NMN as the most efficient precursor. It's available in powders, capsules, and even under-the-tongue forms for faster absorption.
4. Liposomal NAD+ or Precursors
Some brands use liposomal delivery systems. That’s a fancy way of saying they wrap the supplement in tiny fat-like bubbles to help it absorb better. This method may protect the ingredients from breaking down in the stomach so more of it makes it into your bloodstream.
You’ll often see liposomal NMN or NR in sprays, gels, or liquids. While the science behind liposomal delivery is promising, there’s still not a lot of human research comparing it directly with regular capsules.
How to Choose the Right Pure NAD Supplement
Choosing the right pure NAD supplement isn’t just about picking the most popular brand—it’s about finding one that’s clean, effective, and fits your needs. Here’s what to look for:
Purity & Testing: Look for supplements that clearly mention the purity level of their active ingredients (like “99% pure NMN”) and are third-party tested. This helps ensure you’re getting a product free from unnecessary fillers or hidden ingredients.
Type of NAD Precursor: Most pure NAD supplements use NMN (Nicotinamide Mononucleotide) or NR (Nicotinamide Riboside), both of which your body can turn into NAD+. NMN is closer in the conversion chain and often preferred for its efficiency, while NR is widely studied and easy to find.
Delivery Format: Pure NAD supplements come in capsules, powders, sublingual tablets, or liposomal liquids. Powders and sublingual forms may offer better absorption, but capsules are more convenient.
Dose and Daily Use: Check the dosage per serving and how many servings you need daily. Some people prefer a single capsule; others may choose flexible powder forms for custom dosing.
Price vs. Quality: A pure NAD supplement might cost more than a generic blend, but it often offers better results and transparency. Consider it an investment in your long-term health.
Are NAD Supplements Safe?
Pure NAD supplements are generally safe when taken at recommended doses. That means NMN or NR supplements that are clearly labeled, tested for quality, and don’t include unnecessary additives.
Mild side effects like nausea, headache, or digestive discomfort can sometimes occur—especially when starting a new routine. These usually go away as your body adjusts.
As with any supplement, it’s best to talk to your doctor if you’re pregnant, taking medications, or managing a health condition. While the early research on NAD+ is promising, we’re still learning about its long-term effects—especially with high doses.
Who Should Consider Taking a Pure NAD Supplement?
You might benefit from a pure NAD supplement if you're looking for more daily energy, better recovery, or overall healthy aging support. Here’s who might find it helpful:
Adults over 30: NAD+ levels drop with age, and supplements may help restore what the body naturally loses.
Athletes & active individuals: NAD+ supports mitochondrial energy, which can help with endurance and recovery (6).
People under chronic stress: Stress can wear down your cellular health—NAD+ may help replenish it.
Anyone focused on longevity or brain health: Early studies suggest NAD+ plays a role in supporting cognitive function, DNA repair, and inflammation control (7).
Those feeling low on energy or focus: A pure formula ensures you’re getting only what you need to support NAD+ without anything extra.
Conclusion
NAD+ is essential for energy, cell repair, and healthy aging—but our levels naturally drop as we get older. That’s why a pure NAD supplement—made with high-quality NMN or NR—can be a smart addition to your wellness routine.
When choosing one, look for purity, third-party testing, and ingredients backed by research. Whether you want better focus, improved recovery, or just to support your body as it ages, the right supplement can make a difference.
If you're ready to start with something trusted and well-reviewed, Omre NMN + Resveratrol is one of the top picks for 2025. It’s clean, research-backed, and easy to take daily.