David Sinclair’s 2026 supplement stack includes NMN (1g), resveratrol (1g), metformin (800 to 1,000 mg), taurine (2g), fisetin (500 mg), spermidine (1 to 2 mg), fish oil, alpha-lipoic acid (300 mg), vitamin D3, vitamin K2, TMG, aspirin, and rapamycin. Each one supports a different part of aging, like boosting NAD+, improving mitochondria, or reducing inflammation.

Here’s a breakdown of everything Sinclair takes, what each supplement does, and the research behind it.

David Sinclair Supplements 2026: Full Stack Overview

These are the key supplements David Sinclair takes in 2026, based on public interviews, podcast appearances, and his book Lifespan.

What Supplements Does David Sinclair Take in 2026?

Here’s what David Sinclair takes daily in 2026 to support healthy aging, NAD+ levels, and cellular repair:

• NMN (Nicotinamide Mononucleotide) – 1g
• Resveratrol – 1g
• Metformin – 800–1,000mg
• Spermidine – 1–2mg
• Fisetin – 500mg
• Taurine – 2g
• Fish Oil (Omega-3s) – dose not specified
• Alpha Lipoic Acid (ALA) – 300mg
• Vitamin D3 – 4,000–5,000 IU
• Vitamin K2 – 180–360 mcg
• Trimethylglycine (TMG) – 500–1,000mg
• Low-dose Aspirin – 83mg
• Rapamycin – dose not publicly confirmed

NMN (Nicotinamide Mononucleotide) – 1g per day

NMN is a molecule that helps the body produce NAD+, which is essential for energy and cell repair. Sinclair takes 1 gram of NMN each morning, often mixed with yogurt to aid absorption and support cellular health and energy metabolism by boosting NAD+ (nicotinamide adenine dinucleotide) levels.

Scientific evidence suggests NMN can boost NAD+ (nicotinamide adenine dinucleotide), a key component in cellular energy production and DNA repair processes, which naturally decline with age (1).

A 2022 human trial showed NMN may improve muscle strength and insulin sensitivity in older adults. While long-term safety is still being studied, early results are promising (2).

Resveratrol – 1g per day

Resveratrol is a natural compound found in red grapes and berries. It's known for activating sirtuins, proteins that protect our DNA and may slow aging.

Sinclair takes 1 gram of resveratrol every morning with yogurt or olive oil to improve absorption.

He was one of the early researchers to highlight resveratrol's potential. Although human studies are limited, animal studies suggest it may reduce inflammation and improve heart health (3).

Some experts recommend pterostilbene as an alternative due to better absorption, but Sinclair still sticks with resveratrol.

Metformin – 800–1,000mg per day

Metformin is a common diabetes drug that Sinclair uses for its potential anti-aging effects. He takes it at night but skips it on workout days, citing concerns it might interfere with exercise benefits. In his words: "I take metformin not because I have diabetes, but because of its potential to mimic fasting."

Studies have linked metformin to improved insulin sensitivity and even longer lifespans in diabetic patients (4).

Spermidine – 1–2mg per day

Spermidine is a food supplement found in wheat germ and cheese, valued for its role in cellular renewal and promoting autophagy. Sinclair takes it in the morning alongside his other core supplements.

Animal studies show spermidine may support heart health and brain function as we age (5).

Fisetin – 500mg per day

Fisetin is a plant-based compound with senolytic properties found in strawberries and apples. Sinclair takes 500mg in the morning with yogurt to help remove damaged "zombie cells."

Research in mice shows fisetin can extend lifespan and reduce age-related inflammation (6).

Quercetin – 500mg per day (possibly cycled)

Quercetin is another senolytic found in onions and apples. It often works best when paired with fisetin, though Sinclair may now cycle it to avoid interfering with certain cellular pathways (7).

Taurine – 2g per day

Taurine is an amino acid that supports heart health and mitochondrial function (8). Sinclair started taking 2 grams daily after studies showed it extended lifespan in mice.

Fish Oil (Omega-3s) – Dose not specified

Omega-3 fish oil is rich in EPA and DHA, known to support cardiovascular health and reduce chronic inflammation (9). Sinclair recently added it to his stack for brain and heart support.

Alpha Lipoic Acid (ALA) – 300mg per day

ALA is a powerful antioxidant that supports mitochondria and energy production. Sinclair takes 300mg, likely on an empty stomach for better absorption.

Vitamin D3 – 4,000–5,000 IU per day

Vitamin D plays a key role in immune response and maintaining bone strength. A 2017 meta-analysis found that D3 supplements may reduce mortality risk in older adults (10).

Vitamin K2 – 180–360 mcg per day

K2 helps direct calcium to bones instead of arteries. Sinclair takes it daily with vitamin D3 to optimize calcium metabolism (11).

Trimethylglycine (TMG) – 500–1,000mg per day

TMG supports DNA methylation. Sinclair takes 500 to 1,000mg daily alongside NMN to avoid methyl group depletion.

Aspirin – 83mg per day

Sinclair takes a low-dose aspirin daily for its potential to reduce cancer risk and inflammation. This is one of the more debated parts of his protocol due to bleeding risks.

Rapamycin – Dose unknown (likely weekly)

Rapamycin targets mTOR, a key pathway in aging. Both Sinclair and Dr. Peter Attia have discussed its potential in slowing aging. It has extended lifespan in multiple animal studies (12).

Read more:

• Andrew Huberman supplements list
• Bryan Johnson supplements list

What’s New in Sinclair’s Routine for 2026?

In 2026, Sinclair added Taurine (2g/day), Fish Oil, Alpha Lipoic Acid (reintroduced), and Rapamycin (weekly) to his routine based on evolving longevity research.

Supplements David Sinclair May Have Stopped Taking

• Quercetin – Possibly phased out or cycled.
• CoQ10 – No longer mentioned in recent stack updates.
• Alpha Lipoic Acid – Was previously removed, but is now back in the stack.

How These Supplements Target Aging

Sinclair’s stack addresses the Hallmarks of Aging, including NAD+ decline (NMN), mitochondrial dysfunction (Taurine, ALA), and cellular cleanup (Spermidine, Rapamycin).

David Sinclair’s Longevity Lifestyle Beyond Supplements

• Intermittent fasting: Skipping meals to mimic calorie restriction.
• Mostly plant-based diet: Avoiding sugar and red meat.
• Regular exercise: Including strength training and cardio.
• Sauna and cold exposure: Activating stress response pathways.
• Tracking biomarkers: Using frequent lab tests and CGMs.
• Sleep optimization: Prioritizing recovery.

Is It Safe to Try David Sinclair’s Stack?

Always consult with a doctor. While supplements like NMN are over-the-counter, drugs like metformin and rapamycin require medical supervision.

If you’re ready to explore longevity, Omre’s collection includes NMN + Resveratrol, Quercetin + Fisetin, and Spermidine.

Conclusion

David Sinclair’s 2026 routine combines staples like NMN with new additions like taurine and rapamycin. Interested in starting your own journey? Check availability at Omre.

FAQs

What supplements does David Sinclair take daily?

NMN, resveratrol, metformin, spermidine, fisetin, taurine, fish oil, ALA, D3, K2, TMG, aspirin, and rapamycin.

Does David Sinclair still take NMN?

Yes, 1g daily in the morning.

Is rapamycin part of David Sinclair’s stack?

Yes, likely taken on a weekly basis.

Why did Sinclair stop taking quercetin?

Likely concerns over interference with SIRT6, though he still uses fisetin.

Are Sinclair’s supplements safe to try?

Consult a professional, as some are prescription medications.