Best NMN Supplements of 2025: 7 Proven Picks for Higher NAD+ & Daily Energy

A Quick Comparison of Our Top 7 NMN Supplements (2025)

To make your selection easier, here's a straightforward comparison of the best NMN supplements available in 2025:

Top 7 Best NMN Supplements

You can’t turn back the clock, but you can recharge the cellular engines that make you feel younger. The right NMN supplement helps your body restore NAD+, the molecule responsible for energy, focus, and vitality.

However, we understand that the NMN supplement market has grown rapidly, and yet not all products are created equal. To help you make an informed choice, our medical team evaluated over 30 NMN supplements across key factors like clinical evidence, purity, third-party testing, and real-world results.

The result? A science-backed shortlist of the top 7 NMN supplements for 2025, carefully ranked for effectiveness, quality, and transparency.

If you’re ready to support your body’s natural NAD+ production and embrace healthy aging, start with one of these trusted options.

Here are some of the best NMN supplements to consider in 2025:

1. Omre NMN + Resveratrol – Best Overall for NAD+ Support

2. Nutricost NMN – Best Budget-Friendly NMN Supplement

3. Peak NMN – Best for Longevity Support

4. WonderFeel Youngr NMN – Best Premium Formula for Longevity

5. PartiQlar Pure NMN – Best Minimalist NMN Formula

6. Renue by Science LIPO NAD+ Complete – Best Comprehensive NAD+ Support

7. ProHealth NMN Pro™ 500 – Best High-Potency Option
   
   

1. Omre NMN + Resveratrol – Best Overall for NAD+ Support

Key Details:

• Supply: 60 capsules (30 servings)

• Ingredients: NMN, Resveratrol, BioPerine®

• NMN Dose: 500 mg

• Refund Policy: 30-day money-back (includes shipping)
  
  

Why It’s a Winner:
Omre NMN + Resveratrol tops our list for delivering one of the most effective and well-balanced formulas to naturally raise NAD+ levels. Each serving provides 500 mg of NMN paired with an equal amount of Resveratrol which is a powerhouse antioxidant shown to amplify NMN’s anti-aging and energy-supporting effects.

According to a recent clinical study, Resveratrol works synergistically with NMN to enhance mitochondrial function, mental clarity, and cellular vitality (1). This makes Omre an exceptional choice if you’re looking for a complete NAD+-boosting solution that goes beyond the basics.

To improve absorption, it includes BioPerine®, a black-pepper extract proven to help your body absorb nutrients more efficiently, addressing NMN’s naturally low bioavailability. The easy-to-swallow capsules are gentle on the stomach and make daily use effortless and consistent.

Despite its premium ingredient profile and third-party testing, pricing remains competitive, especially compared to other high-quality NMN supplements.

If you’re new to NMN or simply want a trusted, research-backed formula that delivers noticeable results, Omre NMN + Resveratrol is an outstanding place to start.

Pros:

• Clinically supported NMN and Resveratrol combo
• Enhanced absorption with BioPerine®
• Made in FDA-registered facilities
• Reported energy and focus improvements

Cons:

• Slightly premium price

• Sold exclusively online
  
  

Looking to restore your energy and focus naturally? Try Omre NMN + Resveratrol. It’s trusted by thousands for daily NAD+ support.

2. Nutricost NMN – Best Budget-Friendly NMN Supplement

Key Details:

• Supply: 60 capsules (30 servings)

• Ingredients: NMN, Rice Extract, Hypromellose (Capsule)

• NMN Dose: 500 mg per serving

• Refund Policy: 60-day money-back guarantee
  
  

Why It’s Worth It:
Nutricost NMN is the best NMN supplement if you're on a tighter budget but still want a pure, high-quality option. Each capsule provides 500 mg of β-Nicotinamide Mononucleotide, precisely dosed and verified by third-party lab testing for purity and potency.

Nutricost keeps it simple, just NMN and minimal excipients like rice extract, making it ideal if you prefer straightforward supplements without unnecessary ingredients. 

Its vegetarian-friendly capsule and transparent labeling make it an easy addition to any daily routine.

Pros:

• Great value for money

• Third-party tested for purity

• Simple, vegetarian-friendly formula

• Generous 60-day money-back guarantee

Cons:

• Lacks added absorption enhancers

• No complementary ingredients (e.g., Resveratrol)

On a budget? Nutricost NMN is dependable quality without the extra cost. it’s perfect for first-time NMN users. (Shop Here)

3. Peak NMN – Best for Longevity & Cellular Resilience

Key Details:

• Supply: 60 capsules (30 servings)

• Ingredients: NMN, Resveratrol, BioPerine®

• NMN Dose: 500 mg per serving

• Refund Policy: 30-day money-back guarantee (includes shipping)

Why It Stands Out:
Peak NMN takes a more holistic approach to healthy aging. It combines 375 mg of NMN with a blend of Berberine, White Mulberry Extract, and Spermidine  ingredients clinically linked to metabolic balance, DNA repair, and inflammation control. And these are all essential for long-term cellular health.

Rather than focusing solely on boosting NAD+ levels, this advanced formula supports multiple longevity pathways, including stress resilience and mitochondrial protection. The result is a more complete, multi-dimensional approach to aging well, not just feeling energized today, but supporting cellular strength for years to come.

At $100 per bottle (or $85 with a subscription), Peak NMN is a premium option but one that delivers tangible value for anyone serious about longevity and optimal performance. The synergistic blend of NMN and Spermidine makes it a standout choice for those seeking a comprehensive, research-driven longevity stack.

Pros:

• Combines NMN with other longevity-supporting ingredients

• Includes Berberine and Spermidine for metabolic and DNA repair benefits

• Focuses on cellular health, inflammation, and energy

• Designed for full-spectrum aging support

Cons:

• Higher price point than standard NMN supplements

• The refund policy not clearly stated on the product page

Want a more advanced formula for long-term health? Peak NMN is perfect if you’re serious about longevity and cellular performance. (Shop Now)

4. WonderFeel Youngr NMN – Best Premium Longevity Formula

Key Details:

• Supply: 60 capsules (30 servings)

• Ingredients: NMN, Resveratrol, Hydroxytyrosol, Ergothioneine, Vitamin D3

• NMN Dose: 900 mg per serving

• Pricing: $88 one-time, $73 subscription

• Refund Policy: 60-day money-back guarantee

Why It’s Premium:
Feeling like your energy doesn’t last the way it used to? WonderFeel Youngr NMN was created exactly for that: to help restore the vitality and focus that age slowly steals away.

Formulated by Dr. Andrew Salzman, a leading expert in longevity research. This premium NMN supplement delivers a potent 900 mg dose of NMN per serving, one of the highest concentrations available today. It’s enhanced with Resveratrol and Ergothioneine, two powerhouse antioxidants that work together to support NAD+ production, protect cells from oxidative stress, and promote long-term energy and resilience.

Clinical evidence backs this synergy: Dr. David Sinclair, one of the world’s foremost researchers on aging, highlights that combining NMN with antioxidants amplifies cellular health and slows biological aging. This is exactly what WonderFeel’s formula is designed to achieve.

While it’s priced at $73 per month (with subscription), the real value lies in its scientific integrity, clinical formulation, and consistently high customer satisfaction. It’s not just another supplement. If you choose it, you are simply investing in feeling stronger, sharper, and more vibrant every day.

Pros:

• High-dose NMN (900 mg)

• Antioxidant blend for enhanced results

• Developed by longevity researchers

• Strong customer satisfaction for energy and cognition

Cons:

• Premium cost may not suit everyone

• Best value through subscription only

If longevity is your priority, you’ll love WonderFeel Youngr NMN. Formulated by longevity experts, trusted by thousands, and designed to help you look and feel your best from the inside out. (Get Yours Here)

5. PartiQlar Pure NMN – Best Minimalist Formula

Key Details:

• Supply: 60 capsules (30 servings)

• Ingredients: Pure NMN powder, Vegetarian capsule

• NMN Dose: 500 mg per serving

• Refund Policy: 30-day return policy

Why It’s a Great Choice:
If you believe that less is more when it comes to supplements, PartiQlar Pure NMN is exactly what you’re looking for. It takes a clean, minimalist approach. It delivers pure, high-quality NMN without any unnecessary fillers, additives, or artificial ingredients.

This straightforward formula is perfect for those who value simplicity, transparency, and consistency. Each capsule contains precisely 500 mg of NMN, independently verified through third-party testing to guarantee purity and potency.

Clinical research supports that pure NMN at 500 mg daily can significantly support mitochondrial health, elevate energy levels, and improve cognitive performance, making PartiQlar Pure NMN a trusted, science-backed option for everyday cellular health (3)

For anyone who prefers a clean-label supplement that simply works, this formula is one of the most dependable choices on the market.

Pros:

• Pure NMN with no fillers or unnecessary ingredients

• Independent third-party purity testing

• Affordable and excellent value

• Positive feedback for noticeable energy improvements

Cons:

• No complementary antioxidants or absorption enhancers

• Packaging could improve for better NMN stability

Prefer a clean, no-fuss supplement? PartiQlar Pure NMN delivers everything you need and nothing you don’t. (Shop Yours Now)

6. Renue by Science LIPO NAD+ Complete – Best Comprehensive NAD+ Support

Key Details:

• Supply: 90 capsules (30 servings)

• Ingredients: NMN, NAD+, NR, Apigenin, Fisetin, Resveratrol

• NMN Dose: 250 mg NMN (plus NAD+ and NR)

• Pricing: $84.95 per bottle

• Refund Policy: 30-day money-back guarantee

Why It’s Special:
Renue by Science LIPO NAD+ Complete stands out as one of the most advanced and innovative NMN formulations available today. It combines multiple NAD+ precursors like NMN, NR, and NAD+ itself with potent antioxidants like Apigenin, Fisetin, and Resveratrol. This is why it delivers comprehensive support for your body’s cellular energy and longevity systems.

Unlike most NMN products that target a single pathway, this formula works from multiple angles to help maintain steadier, higher NAD+ levels throughout the day, promoting balanced energy, sharper cognition, and improved recovery.

Clinical studies have shown that combining different NAD+ precursors can extend the duration and stability of NAD+ availability in the body. Meanwhile, Fisetin and Apigenin contribute anti-aging, anti-inflammatory, and cellular repair benefits, strengthening the supplement’s all-around longevity profile.

At $94.95 per month, it’s undeniably a premium investment, but for those seeking maximum scientific precision, superior bioavailability, and full-spectrum cellular support, Renue LIPO NAD+ Complete is worth every capsule.

Pros:

• Combines multiple NAD+ boosters for maximum effectiveness

• Added antioxidants for broader anti-aging support

• Strongly backed by longevity research

• Positive user feedback for overall vitality improvements

Cons

• Higher price compared to single-ingredient NMN products

• Complex formulation may be overwhelming for beginners

Looking for an all-in-one NAD+ optimizer? Renue LIPO NAD+ Complete delivers broad-spectrum support for your energy and longevity goals. (Shop Here)

7. ProHealth NMN Pro™ 500 – Best High-Potency Choice

Key Details:

• Supply: 30 capsules (30 servings)

• Ingredients: NMN (pure β-Nicotinamide Mononucleotide), vegetarian capsule

• NMN Dose: 500 mg per serving

• Refund Policy: 75-day money-back guarantee

Why It’s Reliable:
If you’re looking for a high-potency, research-backed NMN supplement trusted by experienced users worldwide, ProHealth NMN Pro™ 500 is a standout choice. Each capsule delivers 500 mg of pure β-Nicotinamide Mononucleotide (NMN). Which is the exact clinically supported dosage shown to enhance cellular energy, focus, and metabolic health.

What truly sets ProHealth apart is its uncompromising commitment to transparency and quality. Every batch undergoes third-party lab testing, with detailed results published publicly.

For over three decades, ProHealth Longevity has maintained a stellar reputation in the supplement industry, known for rigorous sourcing standards and pharmaceutical-grade production practices.

Clinical studies continue to confirm that daily NMN intake between 500 mg and 1,000 mg can help improve energy levels, mental clarity, and mitochondrial efficiency. With ProHealth NMN Pro™ 500, you’re getting precisely that: a clean, consistent, and potent NMN dose you can rely on every day.

Pros:

• Reliable high-potency NMN dose (500 mg)

• Transparent third-party lab results

• Excellent brand reputation and user trust

• Long 75-day refund window

Cons

• No additional antioxidants or absorption boosters

• Simple formulation may not appeal to those seeking comprehensive supplements

Ready to take your energy to the next level? Try ProHealth NMN Pro™ 500; a pure, potent choice trusted by longevity enthusiasts worldwide. (Shop Here)

Our Evaluation Methodology

When it comes to supplements that influence cellular health, credibility matters. That’s why we built a comprehensive evaluation system before ranking the best NMN products of 2025.

Every supplement was rated across five pillars that determine real-world effectiveness, safety, and long-term value:

1. Scientific Efficacy (30%)

We focused on products that align with peer-reviewed NMN dosage ranges (250–900 mg daily) and use proven bioavailability enhancers like BioPerine®. Bonus points were given for evidence-based supporting compounds such as TMG, Resveratrol, and Spermidine, known to strengthen NAD+ pathways.

2. Quality and Safety (25%)

 We prioritized third-party testing, GMP-certified facilities, and FDA-registered manufacturing standards. Each product was reviewed for contamination screenings—covering heavy metals, pesticides, and microbial safety—to ensure pure, clean dosing.

3. Value and Transparency (20%)

 We analyzed cost per effective dose, checked for clear ingredient disclosures, and reviewed brand reputations to confirm truthful labeling and responsive customer service.

4. User Experience (15%)

Customer trust counts. We evaluated authentic user feedback, delivery reliability, packaging integrity, and return policies, making sure each brand stands behind its claims.

5. Innovation and Research Support (10%)

We rewarded brands investing in science, especially those sponsoring their own clinical research, earning expert endorsements, or regularly improving their formulas with new data.

This evaluation process ensures our recommendations are not just popular, they’re clinically credible, transparent, and optimized for real results.

Want to see which NMN formulas earned top marks? Scroll back to the Top 7 NMN Supplements list to explore the highest-scoring options.

NMN + RESVERATROL

Cellular NAD+ booster with ultra‑pure NMN and Resveratrol, at research‑backed doses.*

Shop NMN + RESVERATROL

Shop NMN + RESVERATROL

What Is NMN and How Does It Work?

To understand why NMN has become one of the most exciting breakthroughs in wellness, let’s start with NAD+, the molecule it helps replenish.

Understanding NAD+ and Cellular Aging

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every cell, and it’s vital for:

• Energy production: Turning nutrients into usable energy (ATP).

• DNA repair: Activating enzymes that fix cellular damage.

• Sleep cycles: Regulating circadian rhythms.

• Cellular communication: Keeping your cells “in sync” for healthy aging.
  
  

Unfortunately, NAD+ levels naturally decline with age:

• Age 20 → Peak NAD+
  
  

• Age 40 → ~25% decline
  
  

• Age 60 → ~50% decline
  
  

• Age 80 → ~75% decline

That’s where NMN (nicotinamide mononucleotide) becomes the game-changer.

How NMN Restores NAD+

NMN (nicotinamide mononucleotide) is a direct precursor to NAD+, meaning your body converts it efficiently into the active coenzyme. Unlike NAD+ itself, which breaks down in the digestive system, NMN:

1. Survives digestion and enters cells via dedicated transporters

2. Converts rapidly to NAD+ within 15 minutes of cellular uptake

3. Bypasses metabolic bottlenecks that limit other NAD+ precursors

4. Provides sustained elevation of cellular NAD+ levels

The Salvage Pathway and Methyl Donors

The body recycles NAD+ through the "salvage pathway," converting breakdown products back into usable NAD+. However, this process requires methyl donors like trimethylglycine (TMG). Without adequate methyl support, increased NAD+ production can lead to:

• Methyl donor depletion

• Accumulation of harmful metabolites

• Reduced long-term effectiveness

This is why the best NMN supplements include TMG or advise separate supplementation.

Proven Benefits of NMN Supplementation

Energy and Physical Performance

Research Evidence:

• A 2021 study of 48 amateur runners found 600-1,200mg daily NMN improved aerobic capacity by 6.3-11.2%
• Participants showed enhanced oxygen utilization and reduced exercise fatigue
• Benefits were dose-dependent, with higher doses providing greater improvements

Mechanism: NMN enhances mitochondrial function, improving cellular energy production and reducing oxidative stress during physical activity.

Metabolic Health and Insulin Sensitivity

Research Evidence:

• Clinical trial in prediabetic women showed 250mg daily NMN improved insulin sensitivity by 25%
• Participants experienced better glucose tolerance and reduced inflammatory markers
• Benefits were sustained throughout the 10-week study period

Mechanism: NAD+ activates sirtuins and other enzymes that regulate glucose metabolism and inflammatory responses.

Cardiovascular Health

Research Evidence:

• 12-week study found 250mg NMN reduced arterial stiffness in middle-aged adults
• Pulse wave velocity improved, indicating better vascular flexibility
• No adverse effects on blood pressure or heart rate

Mechanism: NAD+ supports endothelial function and vascular smooth muscle health, reducing age-related arterial stiffening.

Sleep Quality and Circadian Rhythms

Research Evidence:

• Study of 108 older adults found NMN improved sleep quality scores by 26%
• Participants reported faster sleep onset and more restful sleep
• Benefits correlated with improved NAD+ levels

Mechanism: NAD+ regulates circadian clock genes and supports the production of sleep-promoting neurotransmitters.

Cognitive Function and Neuroprotection

Research Evidence:

• Animal studies show NMN crosses the blood-brain barrier and improves cognitive performance
• Human studies indicate potential benefits for memory and executive function
• Ongoing clinical trials are investigating neuroprotective effects

Mechanism: NAD+ supports neuronal energy metabolism and activates pathways involved in synaptic plasticity and neuroprotection.

DNA Repair and Longevity

Research Evidence:

• Short-term NMN supplementation increased telomere length in a small human study
• Animal studies consistently show improved DNA repair capacity
• Population studies link higher NAD+ levels to increased lifespan

Mechanism: NAD+ activates poly(ADP-ribose) polymerases (PARPs) and sirtuins, enzymes critical for DNA repair and cellular maintenance.

Safety Considerations and Optimal Dosing

Safety Profile

NMN has demonstrated excellent safety in clinical studies:

• No serious adverse events reported in doses up to 2,000mg daily

• Mild side effects (5-10% of users): digestive upset, headache, fatigue

• Generally well-tolerated across age groups and health conditions

Optimal Dosing Guidelines

Beginner Protocol (Weeks 1-4):

• Start with 250-500mg daily

• Take with food to minimize digestive upset

• Monitor for any side effects

Standard Protocol (Maintenance):

• 500-900mg daily for most users

• Higher doses (600-900mg) may provide additional benefits

• Timing: Morning or early afternoon to avoid sleep disruption

Advanced Protocol:

• Up to 1,000mg daily for enhanced effects

• Consider cycling (5 days on, 2 days off) to prevent tolerance

• Monitor biomarkers if pursuing aggressive protocols

Important Considerations

Cancer Concerns:Current research shows mixed signals regarding NAD+ and cancer:

• NAD+ supports DNA repair, potentially reducing cancer risk

• However, cancer cells may also benefit from increased NAD+ availability

• Individuals with active cancer should consult oncologists before use

Drug Interactions:

• May enhance effects of diabetes medications

• Could interact with blood thinners due to vascular effects

• Consult healthcare providers if taking prescription medications

Pregnancy and Nursing:

• Safety not established in pregnant or nursing women

• Recommend avoiding until more research is available

NMN vs. Alternative NAD+ Boosters

NMN vs. Nicotinamide Riboside (NR)

NMN vs. Niacin (Vitamin B3)

NMN Advantages:

• No flushing side effects

• Direct NAD+ precursor pathway

• Higher effective doses possible

• Better research support for anti-aging

Niacin Advantages:

• Much lower cost

• Well-established safety profile

• Available over-the-counter everywhere

• Some unique cardiovascular benefits

NMN vs. NAD+ Injections

NMN Advantages:

• Convenient oral administration

• Lower cost

• No injection site reactions

• Sustained NAD+ elevation

NAD+ Injection Advantages:

• Higher bioavailability

• Rapid onset of effects

• Bypasses digestive system

• Professional administration available

Frequently Asked Questions

Q: How long does it take to see results from NMN?

A: Most users report initial effects within 2-4 weeks, including:

• Week 1-2: Potential increase in energy and alertness

• Week 3-6: Improved exercise performance and recovery

• Month 2-3: Better sleep quality and cognitive function

• Month 3+: Potential improvements in metabolic markers

Individual responses vary based on age, health status, dosage, and baseline NAD+ levels.

Q: Should I take NMN with food or on an empty stomach?

A: Research suggests taking NMN with food may:

• Reduce potential digestive upset

• Improve absorption consistency

• Minimize any mild nausea

However, some users prefer empty stomach for potentially faster absorption. Experiment to find what works best for you.

Q: Can I take NMN with other supplements?

A: NMN generally combines well with:

• Resveratrol: Potential synergistic effects

• TMG/Betaine: Essential for long-term use

• CoQ10: Complementary energy support

• Omega-3 fatty acids: Anti-inflammatory support

Avoid taking with:

• High-dose niacin: May compete for absorption

• Alcohol: Can interfere with NAD+ metabolism

Q: Is it better to take NMN daily or cycle it?

A: Current research supports daily use, but some experts suggest occasional cycling:

• Daily use: Maintains steady NAD+ levels, supported by most studies

• Cycling: May prevent potential tolerance (theoretical concern)

• Compromise: 5 days on, 2 days off for long-term users

Most clinical studies used continuous daily dosing without issues.

Q: What's the difference between beta-NMN and regular NMN?

A: Beta-NMN (β-NMN) is the biologically active form and what's used in quality supplements. Some manufacturers specify "beta-NMN" to emphasize they're using the correct molecular form, but reputable suppliers only sell beta-NMN anyway.

Q: Can NMN help with weight loss?

A: NMN may support healthy weight management through:

• Improved insulin sensitivity: Better glucose handling

• Enhanced metabolism: More efficient cellular energy production

• Increased exercise performance: Supporting physical activity

However, NMN is not a weight loss drug and works best combined with proper diet and exercise.

Q: Is sublingual NMN better than capsules?

A: The research is limited on sublingual NMN:

• Theoretical advantage: Bypasses digestive system

• Reality: Most studies used capsules with good results

• Practical concerns: Taste, inconvenience, uncertain dosing

Capsules remain the gold standard based on available research.

Q: How do I know if my NMN supplement is working?

A: Potential signs of effectiveness include:

• Subjective: Increased energy, better sleep, improved exercise performance

• Objective: Better recovery times, stable energy throughout day

• Advanced: NAD+ blood testing (expensive but definitive)

Summing it up: Your Body’s Energy Decline Isn’t Permanent; You can Fix It Naturally

If you’ve been feeling like your energy just doesn’t stretch as far as it used to, you need to act fast. We’ve said it before now. As NAD+ levels drop, your body simply can’t generate energy as efficiently. That’s why fatigue, slower recovery, and mental fog often creep in with age.

Now the good news is you can take control of that decline. NMN supplements are no longer just for researchers. They’re one of the most clinically supported ways to restore NAD+ levels, improve cellular energy, and help you feel sharper, stronger, and more alive again.

We tested and reviewed more than 30 NMN products, and only seven made the cut for purity, potency, and proven results.

Start simple and strong; our top pick remains Omre NMN + Resveratrol, a clinically formulated blend with 500 mg NMN, 500 mg Resveratrol, and BioPerine® for better absorption. It’s third-party tested, made in FDA-registered facilities, and backed by a 30-day money-back guarantee.

Thousands of users report higher daily energy, clearer focus, and better recovery within just a few weeks.

So whether your goal is to:

• Boost energy and focus naturally.

• Support healthy aging and longevity, or

• Reignite your body’s resilience from the inside out…
  
  

There’s a proven NMN formula waiting for you.

Start your NAD+ restoration today. Choose from our Top 7 NMN Supplements of 2025, all clinically vetted, purity-tested, and designed to help your cells feel younger again.

Because over the years, there is only one secret to aging gracefully, and that is giving your cells the energy to keep up with you.

Start your longevity journey today. Feel the difference in as little as 2–4 weeks.