Table of Contents
- What is NAD+?
- What Is NAD and Why Does It Matter for Health?
- NAD+ vs. NADH vs. NR vs. NMN: What’s the Difference?
- Benefits of NAD+ Supplements
- Can NAD Supplements Reverse Aging?
- Risks and Side Effects of NAD+ Supplements
- Do NAD Supplements Really Work? Here’s What Research Says
- How to Choose the Right NAD Supplement
- Can You Boost NAD Naturally Without Supplements?
- Conclusion
- FAQs
If you're feeling low on energy, mentally foggy, or simply curious about anti-aging supplements, you’ve probably come across NAD+.
This coenzyme plays a major role in how our cells function—and its levels decline as we age.
In this guide, we’ll break down what NAD is, whether supplements really help, and share the best NAD+ supplements in 2025 based on expert input, clinical research, and real user feedback.
NMN + RESVERATROL
Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*
Best NAD Supplements: Our Top Picks
Best Overall: Omre NMN + RESVERATROL
Best for Research Backing: TRU NIAGEN
Best Antioxidant Blend: Thorne Advanced Nutrients
Best for Variety of Delivery Methods: Renue by Science
Best for Longevity Research: Elysium Basis
Best Value Subscription: Novos Boost
Best Budget Option: Toniiq NMN 300
Best for Advanced Delivery System: IM8 Daily Ultimate Longevity
Best Liposomal Formula: Codeage Liposomal NAD+ ULTRA
Best Clinically Proven Boost: Qualia NAD+
Best Budget Pick: Life Extension Cell Regenerator + Resveratrol Elite
1. Best Overall: Omre NMN + RESVERATROL
Key Ingredients: Uthever® NMN, Micronized Trans-Resveratrol, BioPerine®
Cost of Monthly Supply: $59.97 (or $50.97 with multipack discount)
Omre’s formula combines ultra-pure NMN with trans-resveratrol and BioPerine® for enhanced absorption.
The NMN source—Uthever®—is one of the most studied forms on the market, and resveratrol is included for its synergy with sirtuin activation, a key pathway in longevity research. BioPerine® (black pepper extract) improves bioavailability.
This supplement is produced in GMP-certified facilities in the USA and is third-party tested for purity and potency.
Users commonly report improvements in energy and mental clarity over time, aligning with findings from early-stage research into NMN’s effects on NAD+ levels and mitochondrial function.
Customer Review: “I’m only 49, but was already feeling the effects of aging. I feel younger, my skin looks better, and I actually think it has slowed my greying.”
2. Best for Research Backing: TRU NIAGEN
Key Ingredients: Nicotinamide Riboside (Niagen®)
Cost of Monthly Supply: $48
Tru Niagen features Niagen®, a patented form of nicotinamide riboside (NR), which has been studied in over 400 scientific publications.
Clinical trials have shown this ingredient can raise NAD+ levels by more than 50% in under two weeks. Its safety profile has been acknowledged by the FDA through multiple New Dietary Ingredient notifications and GRAS (Generally Recognized As Safe) status.
Manufactured in NSF-certified facilities and third-party tested, Tru Niagen supports cellular repair, muscle function, and neuroprotection. It’s widely recommended in academic studies and aging-focused clinics.
Customer Review: “Tru Niagen gives me a clean energy boost that lasts all day. I’ve noticed better focus and overall stamina.”
3. Best Antioxidant Blend: Thorne Advanced Nutrients
Key Ingredients: Nicotinamide Riboside, Resveratrol, Quercetin, Bilberry
Cost of Monthly Supply: $67.45
This multi-functional supplement from Thorne blends NAD+ precursors with antioxidant compounds like quercetin and resveratrol.
These compounds work synergistically to support mitochondrial health, enhance cellular function, and reduce oxidative stress—factors often linked to age-related decline.
Thorne’s products are manufactured with pharmaceutical-level quality standards and are trusted by U.S. National Teams and research hospitals, including Mayo Clinic. The formulation also excludes common allergens and artificial additives.
Customer Review: “I’ve felt more energized and noticed improved recovery time from workouts since switching to Thorne.”
4. Best for Variety of Delivery Methods: Renue by Science
Key Ingredients: NMN, NR, Trigonelline (varies by product)
Cost of Monthly Supply: Around $20 (with 90-capsule pack)
Renue by Science is known for offering a wide range of delivery options, including liposomal capsules, sublingual powders, oral sprays, nasal sprays, and topical formulations. This allows for better personalization based on lifestyle, absorption needs, or preference.
Their NMN and NR products are third-party tested and formulated for maximum bioavailability, and many include absorption enhancers or time-release technology.
The company is involved in ongoing product innovation, and their liposomal encapsulation method is designed to improve nutrient uptake.
Customer Review: “I love that I can add the powder to my smoothie or use the spray on busy days—super flexible and effective.”
5. Best for Longevity Research: Elysium Basis
Key Ingredients: Nicotinamide Riboside (NR-E), Pterostilbene
Cost of Monthly Supply: $60
Elysium Health’s Basis is formulated by Dr. Leonard Guarente of MIT, a pioneer in aging research. It features a proprietary form of vitamin B3 (NR) alongside pterostilbene, a compound related to resveratrol, thought to support sirtuin activity and cellular repair.
A published clinical trial found that Basis significantly increased NAD+ levels in healthy adults by 40%. The supplement is NSF Certified for Sport and manufactured in GMP-compliant facilities.
Customer Review: “I’ve been taking Basis for over a year and feel more mentally sharp and physically active. A great product backed by science.”
6. Best Value Subscription: Novos Boost
Key Ingredients: High-purity (>99%) Nicotinamide Mononucleotide (NMN)
Cost of Monthly Supply: $32 (with subscription)
Novos Boost delivers >99% pure NMN, independently tested for stability and potency. The brand is backed by aging scientists affiliated with Harvard and MIT and promotes evidence-based longevity strategies.
This supplement supports NAD+ production, metabolic health, and DNA repair. It’s intended to be taken daily and can be paired with Novos Core for broader health effects, though it’s effective on its own. It’s free from artificial additives and manufactured in the U.S.
Customer Review: “Novos Boost is the only supplement that’s given me consistent energy and better sleep. Feels clean and effective.”
7. Best Budget Option: Toniiq NMN 300
Key Ingredients: Nicotinamide Mononucleotide (98% purity)
Cost of Monthly Supply: $40
Toniiq offers a straightforward NMN supplement with 98% purity and third-party testing at a competitive price point. It is manufactured in GMP-certified U.S. facilities and rigorously tested for heavy metals and contaminants.
While it doesn’t include extra ingredients or delivery technology, it delivers value and clean formulation. Toniiq also includes a satisfaction guarantee, which adds trust for first-time users.
Customer Review: “Great value for the quality. I’ve definitely noticed a difference in my daily energy levels.”
8. Best for Advanced Delivery System: IM8 Daily Ultimate Longevity
Key Ingredients: NAD3® Complex, Cell Rejuvenation Technology 8™
Cost of Monthly Supply: $75
IM8’s Daily Ultimate Longevity uses a patented delivery system (Capsugel®) to optimize absorption of both water- and fat-soluble ingredients. The formula combines NAD+ precursors with adaptogens, antioxidants, and vitamins to target aging at the cellular level.
It is vegan, free from allergens, and third-party tested for purity and efficacy. The brand emphasizes bioavailability and systems-based design, which appeals to those seeking clinically inspired supplementation.
Customer Review: “IM8 gave me a noticeable boost in mental clarity. It feels like I’m functioning on a higher level.”
9. Best Liposomal Formula: Codeage Liposomal NAD+ ULTRA
Key Ingredients: NAD+, Resveratrol, Quercetin, Betaine, B12, Riboflavin
Cost of Monthly Supply: $89.99
Codeage’s Liposomal NAD+ ULTRA combines a wide range of NAD+ precursors, antioxidants, and B vitamins in a liposomal matrix to aid cellular uptake. Liposomal delivery is designed to bypass degradation in the digestive tract and improve bioavailability.
The formula is non-GMO, gluten-free, and manufactured in the USA in a cGMP facility. It’s a full-spectrum dietary supplement for those focused on comprehensive NAD+ support, cellular health, and nutrient synergy.
Customer Review: “This one made a real difference in my stamina throughout the day. Expensive, but worth it.”
10. Best Clinically Proven Boost: Qualia NAD+
Key Ingredients: Nicotinamide Riboside (Niagen®), B-Vitamin Complex, NAD+ Precursors
Cost of Monthly Supply: $79
Qualia NAD+ is backed by clinical research showing a 67% increase in NAD+ levels. It includes a blend of NAD+ precursors and supportive compounds designed using complex systems science for maximum synergy and mitochondrial support.
Each ingredient is included for a specific role in cellular energy, repair, and cognitive function. The formula is vegan, gluten-free, and third-party tested.
Customer Review: “This is the most powerful NAD+ supplement I’ve tried. I feel younger, sharper, and more focused.”
11. Best Budget Pick: Life Extension Cell Regenerator + Resveratrol Elite
Key Ingredients: Nicotinamide Riboside, Trans-Resveratrol, Quercetin, Fisetin
Cost of Monthly Supply: $15 (with subscription)
Life Extension’s budget-friendly NAD+ support supplement combines NR with resveratrol and other polyphenols that have been studied for their role in cellular aging and inflammation.
The formulation is vegetarian, third-party tested, and supported by the brand’s decades-long reputation in supplement science. Despite the low price, it maintains quality and effectiveness through well-studied ingredients.
Customer Review: “Great value and noticeable results—my energy is up, and it didn’t cost me a fortune.”
NMN + RESVERATROL
Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*
What Is NAD and Why Does It Matter for Health?
NAD stands for nicotinamide adenine dinucleotide. It’s a molecule found in every cell in your body and is essential for turning food into energy. Beyond energy, it also helps with DNA repair, immune function, and maintaining healthy cell activity.
As we get older, our NAD+ levels naturally drop. According to a 2022 review in Nature Reviews Molecular Cell Biology, lower NAD+ levels have been linked to fatigue, aging-related decline, and even metabolic issues (1).
Dr. Christopher Martens, a professor of physiology at the University of Delaware, explains: “NAD is involved in hundreds of reactions, especially in energy production and repairing damage. Its decline may be one of the reasons we feel tired or age faster.”
Because of this, researchers and health experts are exploring ways to boost NAD+ levels—through lifestyle, diet, and increasingly, through supplements like NMN and NR.
NAD+ vs. NADH vs. NR vs. NMN: What’s the Difference?
There are a few different types of NAD-related supplements, and the names can get confusing. Here's a breakdown of the most common ones:
NAD+
This is the active form of the molecule your body uses. While it’s essential, NAD+ itself doesn’t absorb well when taken as a pill. That’s why most supplements use its precursors instead.
Some NAD+ IV therapies deliver NAD+ directly into the bloodstream, but its bioavailability is lower when crossing cell membranes, which is why precursors are often preferred.
NADH
This is the reduced form of NAD+. It helps transport electrons during energy production. Some supplements contain NADH, and while it may support brain and energy function, fewer studies back its effectiveness compared to NR or NMN.
NR (Nicotinamide Riboside)
NR is one of the most researched forms of vitamin B3 and is a widely studied precursor nicotinamide for boosting NAD+.
A study published in Nature Communications showed that taking NR significantly increased NAD+ levels in healthy adults (2). It’s considered stable, safe, and widely available in capsule form.
NMN (Nicotinamide Mononucleotide)
NMN is one step closer to NAD+ than NR. Studies in animals have shown promising results, including better endurance, insulin sensitivity, and longevity (3).
Human trials are more limited, but a 2022 study published in Frontiers in Aging found NMN supplementation increased NAD+ levels and improved energy markers (4).
Benefits of NAD+ Supplements
NAD+ plays a vital role in how our body produces energy, repairs DNA, and maintains healthy cells. As we age, NAD+ levels naturally decline, which can impact everything from metabolism to brain function.
This is why researchers and healthcare professionals are increasingly interested in NAD+ supplements and their potential benefits.
According to Edwina Clark, RD, early studies suggest that NAD+ supplements may support heart health by improving markers like total cholesterol, LDL, and HDL.
Some research has also shown improved insulin sensitivity, muscle function, and aerobic capacity, especially in older adults and athletes (5).
These benefits may stem from NAD’s role in energy production and mitochondrial function, which is essential for how cells generate and use energy efficiently.
Tiffany Ma, RDN, highlights that NAD+ is gaining popularity for its potential cognitive benefits. “With all the attention on brain health and longevity, NAD+ has become more popular due to its brain health-promoting properties.”
This is supported by animal studies and emerging human trials that show a link between NAD+ and memory, focus, and mental clarity.
Dr. Rishi Mandavia explains the core function this way: “NAD plays a big role in your metabolism, which is how your body turns food into energy. It helps with key processes that produce ATP—the energy your cells need to function.”
In other words, low NAD+ levels may mean your body struggles to keep up with its daily energy needs, especially as you get older.
Preclinical studies in rodents have suggested a wide range of benefits, from delaying aging to improving fertility and reducing gut inflammation.
A 2018 human study found that taking nicotinamide riboside (NR) supplements increased NAD+ levels significantly in just six weeks (6).
"We know in both animals and humans, if we ingest these precursors, the amount of NAD in blood goes up dramatically,” said Dr. Christopher Martens, who co-led the study.
That said, more research is needed—particularly in humans with age-related or chronic health conditions. “Some trials are starting to look at groups of people that may be more vulnerable to chronic disease, and who knows, maybe that’s where we’ll see a bigger impact,” Martens notes.
Can NAD Supplements Reverse Aging?
NAD+ has been called a promising tool in the fight against aging—but calling it a miracle cure would be premature. “The NAD stores drop with age, so that’s a very obvious target in terms of slowing down or even reversing the aging process by giving it back to you,” says Dr. Amanda Kahn, a longevity researcher.
The idea is simple: if we can restore NAD+ levels that drop due to age-related decline, we might be able to slow down its effects on cellular function.
Preclinical studies in animals have supported this theory. When NAD+ levels are boosted, animals often show improvements in energy, muscle strength, and even lifespan. But translating those results to humans is still a work in progress.
While NAD+ precursors like NR and NMN have been shown to raise NAD+ levels in the blood, it’s less clear whether that leads to slower aging or fewer age-related diseases in people.
“We’re really still in the early phases of trying to figure out if this stuff is going to have a benefit or not,” says Dr. Christopher Martens. So far, many human trials have focused on healthy individuals, and their results—though promising—are often small in scale.
Still, the potential is worth exploring. NAD+ is involved in DNA repair, mitochondrial health, and inflammation regulation—all key factors in the aging process.
While we don’t yet have all the answers, ongoing studies are helping to build a clearer picture of how boosting NAD+ might support aging well, if not actually reversing it.
Risks and Side Effects of NAD+ Supplements
NAD+ supplements are generally well tolerated by most healthy adults when taken at recommended doses. Mild side effects like nausea, flushing, or headaches may occur, especially with higher doses or IV administration.
As with any supplement, it's important to use them responsibly and consult a healthcare provider if you have underlying conditions.
"Potential side effects include gastrointestinal discomfort, nausea, flushing, and headaches," explains registered dietitian Michelle Routhenstein.
Additional effects like bloating, itching, and changes in digestion have also been reported, according to Edwina Clark, RD. However, these side effects tend to be mild and short-lived for most users.
A 2023 review of NAD+ research found that supplementation was “safe and well-tolerated” in healthy middle-aged and older adults (7).
But experts still caution that long-term safety data is limited. "Given the role of NAD+ in various cellular processes, there are theoretical concerns regarding potential interference with biological pathways," adds Routhenstein.
Dr. Amanda Kahn notes that while oral supplements of NAD+ are generally safe, NAD+ IV therapy carries more risk due to potential infections or improper administration.
“It really depends on who’s doing the IV. A lot of people go to med spas, which are less regulated,” she says. If you experience any adverse effects, stop using the supplement and consult your doctor.
Do NAD Supplements Really Work? Here’s What Research Says
NAD+ supplements can increase NAD+ levels in the body—but their long-term effects on aging and disease are still being studied.
Multiple human studies have shown that precursors like NR and NMN effectively raise NAD+ levels in the blood. A 2018 randomized trial led by Dr. Martens confirmed that NR supplementation boosted NAD+ significantly within weeks (8).
However, researchers also point out that raising NAD+ is just one step. The real question is whether this leads to better health outcomes.
So far, results in animals are promising—showing benefits like improved metabolism, heart function, and even brain health—but larger human studies are still needed.
“There’s strong evidence that these precursors increase NAD+ in the bloodstream,” says Dr. Amanda Kahn, a longevity researcher. “But we’re still learning how that translates into long-term health improvements in people.”
Some users report better sleep, clearer thinking, and more stamina—but individual results can vary.
How to Choose the Right NAD Supplement
Choosing the right NAD supplement isn’t just about grabbing the first bottle you see. It’s about finding a product that’s actually effective, safe, and tailored to your needs. Here are a few key things to consider before making your choice:
Is it third-party tested? - Supplements aren’t tightly regulated, so third-party testing ensures you’re getting what’s promised—no fillers, contaminants, or fake claims.
Check the ingredient label: Does it contain NR or NMN? - Your body can’t absorb straight NAD+ from the gut. Look for precursors like Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN)—both well-studied and shown to increase NAD+ levels effectively.
What form does it come in? - Capsules are most common, but you can also find sublingual powders, nasal sprays, IV drips, or even NAD shots. Capsules are convenient, while sublingual or topical forms may offer faster absorption.
Any dietary preferences or allergies? - If you're vegan or gluten-intolerant, check for labels like vegan-friendly, gluten-free, or no fillers. These make a difference if you're taking the supplement daily.
Price and delivery method - Some brands offer one-time purchases, while others provide subscriptions with discounts. Also, look for formulas that use sustained release technology or ingredients like BioPerine® to improve absorption.
If you’re looking for a clean, research-backed option, OMRE NMN + Resveratrol might be a good place to start. It combines 500mg of ultra-pure NMN with resveratrol in a 2-capsule serving—no fillers, just clinically aligned doses.
It also includes BioPerine®, which helps improve absorption, especially of resveratrol, a fat-soluble compound. The product is third-party tested, made in the USA, and comes in a simple capsule form for daily use.
While individual results vary, many users appreciate its transparency and commitment to ingredient purity.
Can You Boost NAD Naturally Without Supplements?
You can increase your NAD levels naturally without supplements by making certain lifestyle changes that support your body’s own NAD+ production. These methods may not deliver the same concentrated boost as supplements, but they are beneficial for long-term health and maintenance.
Here are some ways to support NAD+ levels naturally:
Exercise regularly – Both aerobic and resistance training have been shown to increase NAD+ production and sirtuin activity.
Try intermittent fasting or time-restricted eating – Fasting helps activate sirtuins and may boost NAD+ levels by increasing metabolic stress in a controlled way.
Get good sleep – NAD+ plays a role in circadian rhythms. Poor sleep can throw off these cycles and reduce NAD+ efficiency.
Limit alcohol and processed sugar – Both can interfere with NAD+ production and deplete your body’s levels over time.
Eat NAD-boosting foods – Foods rich in tryptophan (like turkey, eggs, and dairy) and niacin (like peanuts and brown rice) support NAD+ synthesis.
While these methods may take longer to show effects compared to supplements, they work in harmony with your body and come with other health benefits—making them a great foundation for healthy aging.
Conclusion
NAD+ is a powerful molecule that supports cellular energy production, DNA repair, and overall cellular health—and research shows its levels decline as we age.
While more studies are needed to fully understand its long-term benefits, early evidence suggests that NAD+ supplements—especially those containing NR or NMN—may help support metabolism, brain function, and healthy aging.
From understanding the science behind NAD to knowing which type of supplement to choose, it's clear that quality and expert backing matter.
Whether you're focused on energy, longevity, or recovery, the right NAD+ supplement can be a helpful addition to your routine—especially when paired with a healthy lifestyle.
If you're looking for a research-backed, high-purity option to support NAD+ levels, check availability for Omre NMN + Resveratrol.
FAQs
Can NAD really reverse aging?
NAD+ can’t reverse aging, but it may help slow some of its effects. It supports cellular repair, energy production, and mitochondrial health—all important for healthy aging. That said, more human research is needed to confirm long-term benefits.
Is NR or NMN better?
Both are NAD+ precursors, but NMN is one step closer to NAD+ in the body’s conversion process. NR is more widely studied in humans, while NMN has shown promising results in animal studies. Choosing between them often depends on personal preference and how your body responds.
How long until NAD supplements start working?
Some users report increased energy and focus within 1–2 weeks. Clinical studies on NR show significant increases in blood NAD+ levels within 6 weeks. Full benefits may take longer and vary from person to person.
Can you take NAD daily?
Yes, NAD+ precursors like NR and NMN are typically taken daily and are considered safe for most people. Still, it’s best to follow the product’s instructions and check with your doctor if you have health conditions or take other medications.