Top 15 Anti-Aging Supplements

Here are some of the best anti-aging supplements that may help support healthy skin, energy, and longevity:

• NMN (Nicotinamide Mononucleotide) – Supports NAD+ levels and cellular energy
• Resveratrol – Fights inflammation and supports heart and brain health
• Fisetin – Clears damaged cells and promotes healthy aging
• Curcumin – Natural antioxidant with anti-inflammatory effects
• EGCG (from Green Tea) – Boosts mitochondrial function and supports skin
• Collagen – Improves skin elasticity, hydration, and joint health
• Rhodiola – Helps manage stress and supports energy
• CoQ10 – Supports energy production and heart health
• Crocin (from Saffron) – Supports brain health and mood
• Ashwagandha – Reduces stress and supports joint comfort
• Vitamin C – Boosts collagen, skin repair, and immunity
• Astragalus – May support immune function and telomere health
• Vitamin E – Protects cells from oxidative stress
• L-Theanine – Promotes calm focus and brain health
• Sulforaphane – Supports detox and protects against age-related damage

1. Nicotinamide Riboside / Nicotinamide Mononucleotide (NR / NMN)

Nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) are known to help replenish NAD+ levels—a molecule your cells need for energy, DNA repair, and gene regulation. NAD+ declines with age, and low levels are linked to age-related issues, including physical decline and brain health concerns.

One study of men aged 75 found that supplementing with 1 gram of NR each day for 21 days boosted NAD+ levels in muscle and decreased inflammation markers (1).

Similarly, another study noted that NMN supplements significantly lengthened telomeres—DNA sequences associated with aging—in both humans and mice (2).

For a well-rounded NAD+ booster, OMRE’s NMN + Resveratrol supplement combines pure NMN with Resveratrol, designed to support cellular energy and longevity. It’s highly rated and available as a one-time or subscription option.

2. Fisetin

Fisetin is a natural compound with the unique ability to clear out senescent, or "zombie," cells—old cells that no longer function but still release inflammatory signals that can harm healthy cells.

Animal studies show that fisetin helps reduce these senescent cells, which may improve tissue health and even extend lifespan (3) (4).

If you’re interested in this powerful duo, OMRE's Quercetin + Fisetin supplement provides a potent formula that supports cellular rejuvenation and is designed to help reduce aging markers and inflammation.

3. Curcumin

Curcumin, the active ingredient in turmeric, is known for its antioxidant and anti-inflammatory effects. As we age, cells naturally stop dividing in a process called cellular senescence, which can speed up aging. Curcumin has shown promise in slowing down this process, as it activates proteins that delay cellular aging (5) (6).

Animal studies even suggest that curcumin might extend lifespan and reduce age-related conditions. It’s no wonder that turmeric has been linked to a reduced risk of cognitive decline (7).

4. EGCG

Epigallocatechin gallate (EGCG) is a powerful polyphenol found in green tea with benefits for both heart health and longevity.

EGCG helps rejuvenate mitochondria, the energy centers in our cells, which become less efficient as we age. It also stimulates autophagy, a natural process that removes damaged cellular material, helping cells stay healthy (8).

Studies have linked regular green tea intake with better skin health and less hyperpigmentation from UV exposure, while daily green tea may even reduce age-related stress in brain cells (9).

You can get your EGCG by drinking green tea or opting for a green tea extract supplement for a concentrated dose (10).

5. Collagen

Collagen is essential for maintaining firm, elastic skin. However, collagen production decreases as we age, leading to more visible wrinkles and dryness.

Studies show that collagen supplements can significantly improve skin hydration, texture, and elasticity. For example, in a study with 72 women, taking 2.5 grams of collagen daily improved skin hydration, smoothness, and elasticity (11).

This protein also supports joint and nail health, making it a popular choice for those looking to maintain a youthful appearance inside and out (12).

6. Rhodiola

Rhodiola, a traditional medicinal plant, has gained popularity for its anti-inflammatory and potential longevity-promoting properties.

Animal studies indicate that rhodiola can help reduce inflammation and extend lifespan, though more human studies are needed to fully understand its effects (13) (14).

7. Resveratrol

Resveratrol is a polyphenol antioxidant found in foods like grapes, berries, and red wine. It’s known for activating sirtuins, enzymes that help regulate cellular health and longevity.

While human research is still ongoing, animal studies suggest that resveratrol may increase lifespan by protecting against cellular aging (15).

Its popularity largely comes from the idea that it may offer the benefits of red wine without the alcohol, targeting heart health and supporting brain function.

For those wanting the benefits of Resveratrol along with NAD+ support, OMRE’s NMN + Resveratrol supplement offers a powerful combination to help promote cellular health and longevity.

8. CoQ10

Coenzyme Q10, or CoQ10, is an antioxidant that naturally occurs in the body, playing a key role in energy production and cellular protection. As we age, our CoQ10 levels drop, which can impact our energy and contribute to the natural wear and tear on our cells (16).

Research supports CoQ10’s role in promoting better health in older adults; in one study with 443 participants over four years, CoQ10 and selenium supplements improved quality of life, reduced hospital visits, and slowed physical and mental decline (17).

9. Crocin

Crocin, the vibrant yellow pigment found in saffron, is more than just a culinary delight; it has significant anti-aging properties. This carotenoid offers anticancer, anti-inflammatory, anti-anxiety, and even antidepressant benefits (18, 19).

Animal studies have shown that crocin protects against nerve damage, while in test-tube studies, it helps prevent UV-induced cellular aging in human skin cells (20, 21).

10. Ashwagandha

Ashwagandha, a traditional herb in Indian medicine, has long been used to support joint health, manage stress, and promote overall well-being.

Studies have shown that ashwagandha root extract can improve sleep quality, reduce stress, and support anti-aging effects by enhancing cellular function (22). It’s also known to provide benefits for joint health (23).

11. Vitamin C

Vitamin C is a powerhouse antioxidant that protects cells from damage, regulates inflammation, and boosts immune health. In a study with 80 adults aged 60, higher blood levels of vitamin C were linked to better focus, memory, and decision-making (24).

12. Astragalus

Astragalus, an herb used in traditional Chinese medicine, is known for its stress-relieving and immune-supporting benefits. It’s believed to help slow aging by reducing oxidative stress and preventing cellular damage (25).

One fascinating aspect of astragalus is its potential to activate telomerase, an enzyme that protects telomeres (26).

13. Vitamin E

Vitamin E is essential for immune health and helps regulate inflammation, both of which become more important as we age (27).

14. L-Theanine

L-theanine, an amino acid found in green tea, is well-known for promoting calmness and mental focus (28).

15. Sulforaphane

Sulforaphane is a compound found in cruciferous vegetables like broccoli and is recognized for its strong anti-inflammatory effects. Research has shown it to be promising for longevity (29) (30).

What Causes Aging?

Aging is a natural part of life, but its pace and effects can be slowed with the right lifestyle habits and supplements. Genetics, environment, and lifestyle choices like diet and exercise all play a role in how quickly we age.

Research shows that several anti-aging supplements support your body’s natural defenses, reducing inflammation and cellular damage.

What to Look for in an Anti-Aging Supplement

Natural, Clean Ingredients

Look for plant-based or naturally occurring compounds like NMN, turmeric, or green tea extract. Avoid anything with unnecessary fillers.

Clinically Studied Formulas

The best anti aging supplements aren’t just trendy, they’re backed by science.

Good Absorption

Some vitamins and compounds need to be combined with other ingredients to be properly absorbed.

Third-Party Testing

Third-party testing shows the product actually contains what it says it does.

Matches Your Goals

Choose supplements that fit your personal needs, not just what’s popular.

Other Natural Ways to Slow Down Aging

• Eat more plants – Leafy greens and berries are packed with antioxidants.
• Move your body – Even a daily 20-minute walk helps with blood flow.
• Sleep well – Your body repairs itself while you sleep.
• Protect your skin – Use sunscreen daily.
• Cut stress when you can – Chronic stress takes a toll on your body.
• Stay social and engaged – Spending time with people helps your mood.
  
  

Conclusion

Aging may be a natural process, but with the right supplements, you can support your body’s defenses against its more challenging effects.

If you’re interested in taking your anti-aging regimen a step further, OMRE’s supplements, like their NMN + Resveratrol and Quercetin + Fisetin formulas, offer high-quality options.

Check availability today to discover which OMRE supplement best suits your needs.

FAQs

How long does it take for anti-aging supplements to show results?

The effects vary. Collagen may show improvements within a few weeks, while NMN may take a few months to impact energy levels.

Are anti-aging supplements safe to take with other medications?

Many are safe, but it’s essential to consult your healthcare provider before starting any new supplement.

Can I get enough anti-aging nutrients from my diet alone?

While a balanced diet provides many nutrients, certain compounds like NMN and fisetin are difficult to get in sufficient amounts from food alone.

At what age should I start taking anti-aging supplements?

Many people begin considering them in their 30s or 40s when natural levels of collagen and cellular energy production decline.

Do anti-aging supplements work better if combined with a specific diet or lifestyle?

Yes, supplements are more effective when paired with a healthy lifestyle, including a balanced diet and regular exercise.