I’m a Doctor. Here’s what I tell patients over 50 who say they’re “not as sharp as they used to be.”

The name took a second longer to come back.

You knew it. You’ve known this person for years. And for one long beat in the middle of a conversation, it wasn’t there.

Or it’s the third meeting of the day, and the thing that used to be routine - holding six threads at once, deciding fast - costs more than it should. Or you read the same paragraph twice and realise you weren’t in it the first time.

If you’re over 50 and any of that sounds familiar, I want to say the thing my patients need to hear first, before anything else:

This is almost never what you’re afraid it is.

I’ve had this conversation in clinic more times than I can count. A capable person - running a company, a department, a household, sometimes all three - sits down and says some version of: “I’m not as sharp as I was. Should I be worried?”

The honest answer, for the overwhelming majority, is no. What they’re describing isn’t a disease. It’s a change in capacity - in how much mental energy is available for the demanding part of the day, and how fast it comes back after you’ve spent it.

And capacity is something you can work on.

Your brain is roughly 2% of your body weight and uses something like a fifth of your energy. It is the most energy-hungry organ you own, and “being sharp” is, at the cellular level, mostly a question of whether your brain cells have the fuel to do demanding work on demand.

Deep inside every one of those cells is a molecule called NAD+. It’s central to how cells turn what you eat into usable energy, and to the day-to-day maintenance work that keeps cells running well.

Research suggests NAD+ levels tend to decline as we get older. Exactly how much varies by tissue and by study, so I won’t quote you a dramatic percentage - I distrust those when I see them in supplement ads. What matters is the direction and the pattern: less NAD+ available, less cellular energy on demand, and a body that recovers from a hard day a little more slowly than it did at 35.

That pattern lines up uncomfortably well with what people describe: the mid-afternoon fade, the extra second to find the word, the meeting that used to be easy.

This is not a diagnosis. It’s a mechanism. And mechanisms are useful, because they tell you where to look.

I’m going to give you the same advice I give in the consulting room, in the same order, because if I skipped it you’d be right not to trust the rest of this page.

1. Sleep - actual sleep. Seven hours, most nights, without a screen in the last thirty minutes. Nothing on this page works as well as this does.

2. Move most days. Not a programme. A 30-minute walk. Strength work twice a week if you can. Movement is one of the most reliable things we know of for supporting the brain.

3. Look honestly at alcohol. Not “give it up” - look at it. For many people over 50 the two glasses that used to be fine are now costing them the next morning’s clarity.

If you’re already doing those three, or you’re working on them, then the next thing I say is:

“And look at NAD+.”

Because you can support your body’s NAD+ directly, with a compound called NMN, and that’s the part most people haven’t heard of.

I didn’t set out to sell a supplement. I set out to find one for my own parents, and I couldn’t find one I was willing to put in front of them.

The problem wasn’t that NMN didn’t exist. It was that most of what I found either used a fraction of the dose used in human research, hid the dose inside a “proprietary blend”, or couldn’t show me a lab report for the bottle I’d actually be buying. NMN is sensitive to heat and moisture. A milligram number on a label is a promise, not a fact, unless someone has tested the batch.

So I formulated Omre NMN + Resveratrol the way I’d want it formulated for my family:

• 500 mg NMN per daily dose - the amount used in randomised human trials, at over 99% purity.
• 500 mg micronised trans-resveratrol - the form and dose the research uses, to support the pathways that put NAD+ to work.
• 5 mg BioPerine® - because resveratrol is notoriously hard to absorb on its own.
• Nothing else. No magnesium stearate, no fillers, no “blend”.
• Tested twice - raw ingredients and finished capsules - by an independent lab, and I publish the results. Every batch. The certificate for the current batch is right below this paragraph.
• Made in the USA in a GMP-certified, FDA-registered facility.

I’m careful about how I say this next part, so let me be precise: what follows are reported experiences from real customers, not clinical outcomes, and results vary from person to person.

But when more than 1,500 people have reviewed the same product, and the same notes keep coming up from people in their fifties and sixties, I think you should be able to read them.

I’d rather lose the sale than have you disappointed in week three, so here is the honest timeline.

Weeks 1–3: most people notice nothing. NMN isn’t a stimulant. You won’t feel it the way you feel coffee. In the research, blood NAD+ measures rise within about a month - but you don’t feel a blood test.

Weeks 4–8: this is where most of the reviews above were written. Subtle first. The afternoon doesn’t fall off a cliff. You realise you didn’t reach for the second coffee. The word comes back on time.

90 days: this is when I ask patients to judge it. Same routine, same markers, then decide whether it has earned its place.

If you’re the kind of person who’ll stop at day 18 because nothing has happened yet - and I understand the impulse - this probably isn’t for you, and I’d rather tell you that now.

If you’re willing to give it the same 90 days you’d give any real change, keep reading.

“Is it safe with my medication?” NMN and resveratrol have good safety profiles in the published human trials, and they aren’t stimulants. But I don’t know your history, and this page can’t replace your own doctor. If you take prescription medication - particularly blood thinners or anything for blood sugar - show your doctor the label before you start. Nutrition Facts

“Why not the $25 bottle on Amazon?” You can buy cheaper NMN. Before you do, check three things on its label and lab report: Is it 500 mg of NMN - not a 500 mg “blend”? Is there a published third-party test for the batch? Does it include resveratrol at a research-level dose, in the trans form, with something to help absorption? If it passes all three, buy it; I mean that. Most don’t, and what you save on the bottle you pay for in not knowing what you took. Omre works out at $2.30 a day on a single bottle - [$2.07 on the 3-month supply / $1.84 subscribed - which is less than the coffee it tends to replace at 3 pm.

“How will I know it’s working?” Pick two or three markers before you start and write them down: how often you reach for the afternoon coffee, how the 4 pm meeting feels, how you feel at the end of a long day. Check them at week 6 and week 12. Subjective, yes - but it’s your subjective, measured consistently, which is worth more than “I think I feel better.”

“What if it does nothing for me?” Then send it back. Thirty days, money back, even if the bottle is empty. No forms to fight through. email hello@omre.co; Our team responds to all queries within 6 hours, 24/7.

“Do I have to subscribe?” No. One bottle is $69, full stop. Subscription is there for people who’ve decided to give it the 90 days and would rather not think about reordering - you can skip, pause or cancel any time from your account, and we tell you before every shipment. Save up to 20% with Subscription, Free Delivery and Subscriber offers

“Is it HSA/FSA eligible?” Yes

I’ll end where I started.

If the name is taking a second longer, you are almost certainly not losing anything. You’re running the most demanding organ you have on less cellular energy than it had at 35 - and that is a workable problem.

Sleep. Move. Look at the wine. And look at NAD+.

I formulated this for my own parents. If you decide to try it, give it the 90 days, keep your two or three markers honest, and then judge it the way you’d judge anything else that asks for a place in your morning.

- Dr Pedram Kordrostami, M.D. Founder, Omre

P.S. If you read this far and you’re still skeptical, good - that’s the right instinct in this category. The lab report is above, the guarantee is real, and my email is hello@omre.co. Ask me anything before you buy.

Onset runs four weeks to three months against a thirty-day refund window. Mark day 25 and decide then. It refunds on an opened bottle, which is the only thing that makes thirty days usable.

Every trial above is in PubMed, and two argue against the product. Read Martens and Zhang first.

Then buy one bottle and give yourself what you would give any patient. A real dose, an honest timeline, and permission to conclude it did nothing.

I still type that word most weeks. I would like to keep typing it about other people.