Medically reviewed by Dr. Sara Alisha Khan, MD, PGDMLE

Omre TMG + B-Complex is made for adults who want daily methylation support from TMG, also known as trimethylglycine or betaine, along with active forms of key B vitamins.

Each serving provides 1000 mg TMG as betaine anhydrous, plus active vitamin B2, vitamin B6, folate, and vitamin B12. The formula is designed to support healthy methylation, homocysteine metabolism, cellular function, energy metabolism, and healthy aging.

Methylation is a normal process your body uses every day. It helps with many cellular functions, including DNA-related processes, neurotransmitter activity, detoxification pathways, and homocysteine recycling. Think of it as one of the body’s quiet background systems. You may not feel it working in the moment, but your cells rely on it all the time.

TMG is a methyl donor, which means it can help provide methyl groups used in the methylation cycle. The B vitamins in this formula help support related methylation pathways. That is why Omre combines TMG with active B vitamins instead of offering a plain TMG supplement on its own.

This product is not a medicine and does not treat, cure, or prevent disease. It is a daily supplement for adults who want a clean, tested TMG and B-complex formula that is easy to compare.

Why People Choose Omre TMG + B-Complex

Omre TMG + B-Complex is made for people who want more than a basic TMG supplement.

Each serving gives you:

• 1000 mg TMG as betaine anhydrous
• 5 mg Vitamin B2 as R5P, Riboflavin-5’-Phosphate
• 5 mg Vitamin B6 as P5P, Pyridoxal-5’-Phosphate
• 1000 mcg DFE Folate from 600 mcg L-5-Methyl Folate
• 250 mcg Vitamin B12 as Methylcobalamin
• 30 servings per bottle
• Vegan capsules
• Third-party lab testing
• Testing for dose, purity, bacteria, fungus, and heavy metals
• Made in the USA
• Made in GMP-certified facilities
• Doctor-developed formulation
• 30-day money-back guarantee
• Free US shipping on orders over $80

Many TMG supplements only provide betaine anhydrous and stop there. Omre takes a more complete route by pairing TMG with active B vitamins that support the wider methylation cycle.

It is a strong fit for shoppers comparing TMG supplements by dose, vitamin forms, methylation support, homocysteine support, testing, and ingredient transparency.

What This TMG Supplement Supports

Omre TMG + B-Complex is designed to support:

• Healthy methylation
• Homocysteine metabolism
• Cellular function
• Healthy aging
• Energy metabolism
• Healthy mitochondrial function
• Mental clarity
• Day-to-day focus
• Supports already-healthy homocysteine levels for cardiovascular health
• Metabolic health support
• Long-term cellular resilience

TMG and B vitamins do not work like caffeine or a quick stimulant. They support background pathways your body already uses. For many people, the goal is not a sudden jolt. The goal is steady methylation support as part of a daily wellness routine.

Doctor-Developed Methylation Support

“As a gastroenterologist, I focus on how nutrients are absorbed and the purity of what people consume. Omre’s commitment to bioavailable, clean ingredients reflects what I believe supplements should prioritise.”

Dr. Sung Jae Hwang
Medical Doctor, MD
Gastroenterologist

Supplement Facts

Serving Size: 2 vegan capsules

Servings Per Container: 30

Vitamin B2

• Amount: 5 mg
• Form: R5P, Riboflavin-5’-Phosphate

Vitamin B6

• Amount: 5 mg
• Form: P5P, Pyridoxal-5’-Phosphate

Folate

• Amount: 1000 mcg DFE
• Form: From 600 mcg L-5-Methyl Folate

Vitamin B12

• Amount: 250 mcg
• Form: Methylcobalamin

Trimethylglycine

• Amount: 1000 mg
• Form: Betaine Anhydrous

Other Ingredients:

• Vegetable cellulose capsule
• Nu-FLOW® rice concentrate

Free From:

• Gluten
• Dairy
• Soy
• Artificial colors
• Preservatives
• Flavouring

Suggested Use: Take 2 capsules daily with food, or as directed by your healthcare provider.

Quality & Testing:

• Third-party lab tested
• Tested every batch
• Tested for dose, purity, bacteria, fungus, and heavy metals
• Made in the USA
• Made in GMP-certified facilities
• 30-day money-back guarantee
• Free US shipping on orders over $80

Storage: Store in a cool, dry place.

Price and Serving Value

Omre TMG + B-Complex is priced at $35.00 per bottle. Each bottle provides 30 servings.

That breaks down to:

• $1.17 per serving, based on the one-time purchase price
• 1000 mg TMG per serving
• 4 active B vitamins per serving
• 30 daily servings per bottle

Subscription pricing is also available at $33.25 per bottle for a 1-month supply, based on the current Subscribe & Save option.

Price should not be judged by TMG dose alone. A better comparison looks at the TMG amount, B-vitamin forms, serving size, testing, manufacturing standards, and refund policy.

A cheaper TMG supplement may look appealing at first. But if it does not include methylation-supporting B vitamins, active vitamin forms, or clear testing details, the real value may be harder to judge.

What Is TMG?

TMG stands for trimethylglycine. It is also known as betaine, betaine anhydrous, or glycine betaine in supplement and nutrition discussions.

TMG is called a methyl donor because it can help provide methyl groups used in normal methylation processes. One important pathway involves helping the body recycle homocysteine back into methionine.

Homocysteine is an amino acid made during normal protein metabolism. The body has built-in pathways for keeping homocysteine in balance. These pathways depend on nutrients such as folate, vitamin B12, vitamin B6, riboflavin, and methyl donors like TMG.

Research in healthy adults has found that betaine supplementation can lower plasma homocysteine levels, with studies using doses such as 1.5 g, 3 g, and 6 g per day (1). Omre provides 1000 mg TMG per serving, paired with active B vitamins for daily methylation support.

How to Take Omre TMG + B-Complex

Take 2 capsules daily with food, or as directed by your healthcare provider.

Simple routine:

• Take 2 capsules daily
• Take with food
• Use consistently
• Store in a cool, dry place
• Speak with your healthcare professional if you take medication or manage a medical condition

Some people prefer taking methylation support supplements earlier in the day because the formula includes B vitamins. That said, the best timing is the one you can stick with.

What Is Methylation?

Methylation is a normal biochemical process where the body transfers small chemical groups called methyl groups.

Your body uses methylation in many areas, including:

• DNA-related processes
• Homocysteine metabolism
• Methionine recycling
• Neurotransmitter-related pathways
• Liver-related detoxification pathways
• Cellular repair and maintenance
• Healthy aging processes

With age, methylation patterns can become less consistent. This is sometimes discussed in healthy aging research as epigenetic drift.

That does not mean a supplement can “reverse aging.” A more accurate way to say it is this: methylation-supporting nutrients may help provide the body with compounds it already uses to keep these pathways running.

Why Omre Combines TMG with Active B Vitamins

TMG is useful on its own, but methylation is not a one-ingredient process.

Omre combines TMG with active B vitamins because these nutrients support connected parts of the methylation cycle.

The formula includes:

• TMG as betaine anhydrous
• Vitamin B2 as R5P
• Vitamin B6 as P5P
• Folate as L-5-Methyl Folate
• Vitamin B12 as Methylcobalamin

Folate and vitamin B12 help support the conversion of homocysteine back into methionine. Vitamin B6 supports another homocysteine pathway that helps convert homocysteine toward cysteine. Riboflavin, or vitamin B2, supports enzymes involved in folate and methylation metabolism.

This is why a TMG + B-complex supplement may be more relevant than plain TMG for people looking at methylation support.

Active B Vitamins in Omre TMG + B-Complex

Omre uses active or methylation-friendly forms of key B vitamins. These vitamins help support the nutrient network around TMG, methylation, and homocysteine metabolism.

Vitamin B2 as R5P

R5P stands for riboflavin-5’-phosphate. It is the active coenzyme form of vitamin B2. Riboflavin supports normal energy metabolism and helps enzymes involved in methylation-related pathways.

Vitamin B6 as P5P

P5P stands for pyridoxal-5’-phosphate. It is the active form of vitamin B6. Vitamin B6 supports amino acid metabolism and helps with the transsulfuration pathway, one route the body uses to process homocysteine.

Folate as L-5-Methyl Folate

L-5-Methyl Folate, also called 5-MTHF, is the main form of folate found in blood. Folate helps support methylation and the conversion of homocysteine into methionine (2).

Vitamin B12 as Methylcobalamin

Methylcobalamin is a form of vitamin B12 involved in methylation-related pathways. Vitamin B12 works with folate in homocysteine metabolism. Together, these B vitamins help support the wider methylation cycle around TMG.

TMG vs Betaine: Are They the Same?

In supplement labels, TMG and betaine are closely related terms.

TMG stands for trimethylglycine. Betaine is another common name for the same compound. Betaine anhydrous refers to the supplemental form used in many TMG products.

So when you see these terms, they are generally referring to the same active compound:

• TMG
• Trimethylglycine
• Betaine
• Betaine anhydrous

Omre TMG + B-Complex provides 1000 mg trimethylglycine as betaine anhydrous per serving.

TMG Supplement vs Methylated B Complex

A plain TMG supplement mainly provides a methyl donor. A methylated B complex usually provides B vitamins such as methylfolate, methylcobalamin, and sometimes active B6 or B2.

Omre sits between these two categories. It gives you 1000 mg TMG, plus active B vitamins that support the wider methylation cycle.

Omre TMG + B-Complex

• Provides 1000 mg TMG
• Includes active B2, B6, folate, and B12
• Supports methylation and homocysteine metabolism
• Made for daily methylation support

Plain TMG Supplement

• Provides TMG only
• May not include supportive B vitamins
• May be less complete for people focused on methylation pathways

Methylated B Complex

• Provides B vitamins
• May not include TMG
• May not provide direct methyl donor support from betaine

For people comparing methylation supplements, Omre offers both TMG and key B vitamins in one formula.

TMG and Homocysteine Support

Homocysteine is part of normal amino acid metabolism. The body can recycle homocysteine back into methionine, or move it into other pathways.

This process depends on nutrients such as:

• Folate
• Vitamin B12
• Vitamin B6
• Vitamin B2
• TMG

A review of randomized trials found that folic acid lowered blood homocysteine, with vitamin B12 adding further support in some studies (3). Research has also found that betaine supplementation can lower plasma homocysteine in healthy adults, although studied doses and outcomes vary (1).

Omre TMG + B-Complex is designed to support these normal pathways. It is not intended to diagnose, treat, cure, or prevent high homocysteine or cardiovascular disease.

If you have known high homocysteine, heart disease risk, kidney disease, or a medical condition, speak with your healthcare professional before using any supplement.

TMG and MTHFR: What Shoppers Should Know

Many people searching for TMG supplements are also interested in MTHFR, methylfolate, and methylated B vitamins.

MTHFR is an enzyme involved in converting folate into 5-MTHF, the main folate form used in methylation. Some people have MTHFR gene variants that may affect this conversion. The NIH notes that the 677C>T MTHFR polymorphism can reduce the ability to convert folate to 5-MTHF and may affect methylation potential in some people (2).

That does not mean everyone needs methylated vitamins or TMG. It also does not mean a supplement can fix a gene variant.

The practical takeaway is simpler: Omre uses L-5-Methyl Folate and methylcobalamin, along with TMG, for people who want a methylation-focused formula with active forms clearly listed.

TMG Capsules vs TMG Powder

TMG supplements come in capsules, powders, and sometimes tablets. Omre TMG + B-Complex comes in vegan capsule form. Capsules are simple, travel-friendly, and easier to dose than powders for many people.

When comparing TMG capsules and TMG powder, check:

• TMG dose per serving
• Form of TMG
• Added B vitamins
• Folate form
• B12 form
• Serving size
• Testing standards
• Other ingredients
• Safety warnings
• Refund policy

Powders may work for people who want flexible dosing. Capsules may work better for people who want a clean daily routine without measuring scoops.

Omre vs Other TMG Supplements

Many TMG supplements look simple at first. The label may say TMG 500 mg, TMG 1000 mg, betaine anhydrous, or trimethylglycine.

The details matter. Omre uses 1000 mg TMG as betaine anhydrous per serving. It also includes active forms of B2, B6, folate, and B12, which many plain TMG products do not include.

When comparing products, look at:

• TMG amount per serving
• TMG form
• B vitamins included
• Active vitamin forms
• Folate type
• B12 type
• Third-party testing
• Heavy metal testing
• Microbial testing
• Manufacturing standards
• Clear directions
• Refund policy

Omre is third-party tested for dose, purity, bacteria, fungus, and heavy metals, and it is made in the USA in GMP-certified facilities.

Why Omre Is Worth Comparing With Top TMG Supplements

Omre TMG + B-Complex is worth comparing with other top TMG supplements because it covers the main details careful shoppers look for: TMG dose, active B vitamins, methylation support, testing, and manufacturing quality.

The formula uses 1000 mg TMG as betaine anhydrous and includes active forms of B2, B6, folate, and B12. That gives shoppers clear ingredient amounts without relying on a hidden proprietary blend.

It is also third-party tested for dose, purity, bacteria, fungus, and heavy metals.

Omre does not need to claim it is the number one TMG supplement. The better point is simpler: the formula is clear, tested, and built around nutrients that fit the methylation support category.

Important Safety Information

Omre TMG + B-Complex is made for adults. Talk with your healthcare professional before use if you take prescription medication, have a medical condition, or are planning a medical procedure.

Do not use this product if you are pregnant, nursing, or under 18 unless your healthcare provider tells you to.

Speak with your healthcare professional first if you have a medical condition, take prescription medication, or have been told you have high homocysteine, kidney disease, cardiovascular concerns, or a mood disorder.

B vitamins and methyl donors may not feel the same for everyone. Stop use and contact a healthcare professional if you notice an unwanted reaction.

Keep out of reach of children. Store in a cool, dry place.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What Customers Are Saying

Omre TMG + B-Complex is rated 5.0 out of 5 stars.

Early review themes include:

• Some customers reporting better energy
• One customer mentioning less afternoon crash after about 30 days
• Buyers liking the TMG and B vitamin combination
• Buyers mentioning easy use and an aesthetic product experience

From Omre

Why We Made Omre TMG + B-Complex

Omre TMG + B-Complex was made for people who want daily methylation support without piecing together several separate supplements.

The supplement shelf can get confusing fast. One product sells TMG alone. Another sells methylated B vitamins. Another uses a long blend without clear amounts.

Omre keeps the formula direct: 1000 mg TMG, active B vitamins, clear serving details, and third-party testing.

Our Formulation Philosophy

Omre TMG + B-Complex was built around two core choices.

First, the formula uses 1000 mg TMG as betaine anhydrous, a well-known methyl donor used in methylation and homocysteine metabolism research.

Second, it includes active forms of B2, B6, folate, and B12 to support related methylation pathways.

The goal is not to make a noisy label. The goal is to make a daily formula that is easy to understand and easy to compare.

Our Quality Promise

Every bottle is made in the USA in GMP-certified facilities. The formula is third-party tested for dose, purity, bacteria, fungus, and heavy metals.

Omre gives shoppers the details they need before buying: active ingredient amounts, serving size, vitamin forms, testing standards, and manufacturing quality.

The Omre Difference

Omre does not use a hidden proprietary blend in this formula. Each active ingredient amount is listed clearly.

That matters because two TMG supplements can look similar at first glance but offer very different doses, vitamin forms, testing standards, and ingredient quality.

How to Choose a TMG Supplement

TMG supplements can look similar online. One bottle may say TMG 500 mg. Another may say TMG 1000 mg, betaine anhydrous, methylated B complex, or methylation support.

Before buying, check:

• How much TMG is in each serving?
• Is the TMG form listed clearly?
• Does it include supportive B vitamins?
• Are the B vitamins active forms?
• Does it use L-5-Methyl Folate or folic acid?
• Does it use methylcobalamin or another B12 form?
• Is the product third-party tested?
• Does the brand test for heavy metals and microbes?
• Is it made in a GMP-certified facility?
• Are the directions and safety warnings easy to find?
• Is there a refund policy?

A higher TMG number on the label does not automatically mean a better product. Dose, formula design, testing, and transparency all matter.

Omre TMG + B-Complex was made for people who want 1000 mg TMG, active B vitamins, third-party testing, and clear serving details in one daily methylation support supplement.

Frequently Asked Questions

What is the best TMG supplement?

The best TMG supplement depends on the dose, formula design, testing standards, ingredient transparency, and your health goals. Omre TMG + B-Complex provides 1000 mg TMG as betaine anhydrous, plus active B2, B6, folate, and B12 for methylation support.

Is Omre TMG + B-Complex a TMG 1000 mg supplement?

Yes. Each serving provides 1000 mg TMG as betaine anhydrous. It also includes active forms of vitamin B2, vitamin B6, folate, and vitamin B12.

What does TMG do?

TMG acts as a methyl donor. It supports normal methylation pathways and helps the body recycle homocysteine back into methionine.

Is TMG the same as betaine?

Yes, TMG is also called betaine or trimethylglycine. In supplements, it is commonly listed as betaine anhydrous.

What is methylation?

Methylation is a normal process where the body transfers methyl groups. It supports many cellular functions, including homocysteine metabolism, DNA-related processes, neurotransmitter-related pathways, and healthy cellular maintenance.

Why does Omre include B vitamins with TMG?

Omre includes active B vitamins because methylation is not a one-nutrient process. Folate, B12, B6, and B2 all support connected pathways involved in methylation and homocysteine metabolism.

What is L-5-Methyl Folate?

L-5-Methyl Folate, also called 5-MTHF, is the main form of folate found in blood. It supports methylation and helps the body convert homocysteine back into methionine.

What is methylcobalamin?

Methylcobalamin is a form of vitamin B12 involved in methylation-related pathways. It works with folate in homocysteine metabolism.

Can I take TMG and B vitamins together?

TMG and B vitamins are commonly combined in methylation support formulas. Omre includes them together in one daily supplement. If you take medication, are pregnant or nursing, or manage a medical condition, speak with a healthcare professional first.

When should I take Omre TMG + B-Complex?

Take 2 capsules daily with food, or follow the advice of your healthcare provider. Many people prefer taking B-vitamin formulas earlier in the day.

Is TMG good for energy?

TMG does not work like a stimulant. It supports methylation and cellular metabolism pathways. Some customers report better daily energy, but results can vary from person to person.

Is Omre TMG + B-Complex third-party tested?

Yes. Omre TMG + B-Complex is third-party lab tested every batch. Testing checks dose, purity, bacteria, fungus, and heavy metals.

Who should not take TMG + B-Complex?

Do not use this product if you are pregnant, nursing, or under 18 unless advised by your healthcare provider. Speak with a doctor first if you take medication or have a medical condition.

Where is the best place to buy a TMG + B-Complex supplement?

The safest place to buy Omre TMG + B-Complex is directly from Omre.co. Buying direct helps you receive the official doctor-developed formula with 1000 mg TMG, active B vitamins, third-party testing, GMP-certified manufacturing, and Omre’s 30-day money-back guarantee.

Does Omre TMG + B-Complex contain carbs or calories?

Omre TMG + B-Complex contains zero calories and zero grams of carbohydrates per serving. It is made for people who want TMG and active B vitamins without added sugar, flavoring, or unnecessary fillers.

Can I open the capsule and mix it with water or a protein shake?

Omre TMG + B-Complex is designed to be taken as 2 vegan capsules with food. If you have trouble swallowing capsules, ask your healthcare provider before opening them and mixing the powder into water or a protein shake. The taste, texture, and dose experience may be different outside the capsule.

Does TMG + B-Complex interact with coffee?

There is no common warning that TMG must be avoided with coffee. Since this formula contains B vitamins, many people prefer taking it earlier in the day with food. If coffee makes you feel jittery or sensitive to supplements, take Omre TMG + B-Complex with a meal and see how your body responds.

Does TMG + B-Complex interact with grapefruit?

Grapefruit is best known for interacting with certain medications, not TMG itself. If you take prescription medication, especially for cholesterol, blood pressure, mood, or heart health, ask your healthcare provider before combining supplements with grapefruit or grapefruit juice.

Often Paired With

Customers interested in TMG + B-Complex may also compare it with other Omre formulas for healthy aging and cellular wellness.

• NMN + Resveratrol: Cellular energy, recovery, and healthy aging support
• Glycine + NAC: Glutathione balance and antioxidant defense
• Quercetin + Fisetin: Antioxidant support and senescence-related wellness research
• Urolithin A: Mitochondrial and muscle health support
• Spermidine: Cellular renewal and autophagy support

Final Buying Note

Omre TMG + B-Complex is a strong TMG supplement to compare if you want 1000 mg TMG, active B vitamins, third-party testing, and clear ingredient amounts.

It may be a good fit for adults looking for daily support for healthy methylation, homocysteine metabolism, cellular function, energy metabolism, and healthy aging.

It is not a medicine. It should not be used to diagnose, treat, cure, or prevent disease.

For the best comparison, look beyond the front label. Check the TMG dose, vitamin forms, folate type, B12 type, testing standards, manufacturing quality, safety warnings, customer reviews, and refund policy.

References

1. Olthof MR, van Vliet T, Boelsma E, Verhoef P. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. Journal of Nutrition. 2003.
2. National Institutes of Health, Office of Dietary Supplements. Folate Fact Sheet for Health Professionals.
3. Clarke R, et al. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ. 1998.
4. McRae MP. Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis. Journal of Chiropractic Medicine. 2013.