You've read about mitophagy. The hard part is knowing which bottle delivers the dose the trials used.

You've compared urolithin A supplements by label. You've seen $35 and $99 bottles that both say 500 mg. You may already take NMN and want the right partner for it.

We make one of these.

So we held all five to the same checks we built ours to pass: the dose the human trials used, direct urolithin A, a lab report you can read, a formula you control, and a guarantee that covers the bottle you tried.

Then we ranked them. Ties go to the lower cost per day.

What most labels leave out

Your gut makes urolithin A from compounds in pomegranate and walnuts. Most people make little of it.

So a bottle of pomegranate extract or ellagic acid is a bet on your gut bacteria. Direct urolithin A skips the bet.

Dose is the second gap. The human trials used 500 mg to 1,000 mg a day. A label with a smaller number, or a dose folded into a blend total, sits below the evidence.

Purity is the third. "High purity" on the front of a bottle is a word. A third-party lab report with milligrams per capsule and a heavy-metals line is a number.

The five checks below turn those gaps into questions you can ask of any bottle.

The 5 checks that matter

How the top 5 compare

Swipe the table sideways to see every column →

Cost per day is the one-time bottle price ÷ 30 servings, at time of writing, Oct 2026.

Urolithin A supplements, ranked

1. Omre Urolithin A: all five checks, $2.30 a day

2. Codeage Liposomal Urolithin A: ties on checks, $2.33 a day

3. Timeline Mitopure Softgels: the trial ingredient, $3.30 a day

4. Toniiq Urolithin A Complex: lowest cost, one check missed

5. Perpetua Life Urolithin-A Liposomal: highest dose, two checks missed

The proof behind our #1

Every batch is independently third-party tested for dose, purity and contaminants. The report is on the product page, with milligrams per capsule, heavy metals and microbes on the same sheet.

It's made in the USA in a GMP-certified, FDA-registered facility.

Omre was founded by Dr. Pedram Kordrostami, a London-trained medical doctor. He practiced in the NHS across general internal medicine, dermatology and emergency medicine. He now focuses on evidence-based longevity science. Founded by a doctor, for his family.

HSA/FSA eligible through Truemed.

When reviewers answer "What changes have you felt?", more energy is the top answer, then less brain fog and better physical performance.

"I've been taking this for a month and I can already tell a difference!" — William D., verified buyer

Start with one bottle, backed by 30 days →

Questions before you buy

What is urolithin A supplement good for?

It supports mitophagy, the process your cells use to clear worn-out mitochondria and make room for new ones. In human trials, 4 months of daily urolithin A supported muscle strength and endurance in middle-aged and older adults. Our reviewers report energy and recovery first.

Is urolithin A worth taking?

The human trials ran 4 weeks to 4 months at 500 mg to 1,000 mg a day. They measured safety, mitochondrial markers, strength and endurance. If that's what you want supported, a bottle that passes the five checks is worth a 30-day trial.

Is it safe with my medications?

Ask your doctor first if you take any prescription medication, especially blood thinners or medicines processed by the liver's CYP450 enzymes. Do not use if you are pregnant, nursing or under 18. Urolithin A was well tolerated at up to 1,000 mg a day in the trials.

Why pay more than a cheaper bottle?

Compare cost per verified daily dose. Omre is $2.30 a day for 500 mg of direct urolithin A with a full lab report. Toniiq is $1.17 a day, with 117 mg of NMN you didn't choose. Perpetua is $1.97 a day with a potency-only report.

Do I have to subscribe?

No. One-time purchase is $69. Subscribe & Save takes 5% off a 1-month supply, 10% off 3 months and 20% off 6 months. Cancel, skip or pause anytime. US shipping is free over $80.

Is liposomal urolithin A better?

"Liposomal" means the urolithin A is wrapped in phospholipids. The trials that produced the results used direct urolithin A at 500 mg to 1,000 mg a day. Hold a liposomal bottle to the same five checks and compare cost per day.

The bottom line