Mitopure is the urolithin A most people find first, so the real question is what your $99 buys.

You've read about mitophagy. You've seen the trials. You've seen the price.

Maybe you've tried Mitopure already. Maybe you're comparing it with urolithin A bottles that cost less.

We make one of these.

So we held Mitopure and four others to the same four checks we built ours to pass.

First, what is in Mitopure. Then the checks, so you can use them on any bottle. Then the ranking.

What is in Mitopure

Mitopure is Timeline's brand name for urolithin A. Timeline's parent company, Amazentis, ran the best-known human trials on it.

The molecule is urolithin A. Other brands sell the same molecule.

So the useful question is which bottle proves what its label says.

Where urolithin A labels differ

You want energy and strength that last. Urolithin A has human trials behind that goal.

In healthy older adults, 250 to 1,000 mg a day for 4 weeks was well tolerated. At 500 and 1,000 mg, it changed muscle gene activity linked to healthy mitochondria.

In middle-aged adults, 500 or 1,000 mg a day for 4 months improved leg muscle strength compared with placebo.

So the dose is easy to check. The rest takes more digging.

"Highly pure" is a word. 98% is a number.

"Third-party tested" can mean a potency check only. Heavy metals and microbes need their own lines on the lab report.

Guarantees have fine print too. Some refund only unopened bottles. With those, you can't try the product and still get your money back.

You should be able to check all of this before you pay.

The 4 checks that matter

Hold any urolithin A bottle to these four.

We rank by checks passed. Ties go to the lower cost per day.

In our last customer survey, 93% said evidence matters more to them than price.

How the top 5 compare

Swipe the table sideways to see every column →

One-time prices at time of writing, for one label serving a day.

Mitopure and 4 alternatives, ranked

Our pick is Omre Urolithin A. It's the lowest-cost bottle here that passes all 4 checks.

1. Omre Urolithin A: All 4 checks, lowest cost

2. Timeline Mitopure Softgels: All 4 checks, $3.30 a day

3. Codeage Liposomal Urolithin A: NSF seal, no purity number

4. Perpetua.Life Urolithin-A Liposomal: Higher dose, fewer published results

5. Aeternum Urolithin A: Highest stated purity, unopened returns only

The proof behind our #1

You want to know who stands behind the bottle.

Every batch of Omre Urolithin A is independently tested for dose, purity and contaminants, including heavy metals and microbes. The lab report sits on the product page.

It's made in the USA in a GMP-certified, FDA-registered facility.

Omre was founded by Dr. Pedram Kordrostami, a London-trained medical doctor who practiced in the NHS. His GMC number is 7528786.

Some reviewers notice it within weeks:

Start with one bottle, backed by 30 days →

Questions before you buy

Is Mitopure the same as urolithin A?

Yes. Mitopure is Timeline's brand name for its urolithin A, which Timeline states is made at over 99% purity. Other brands sell the same molecule. What changes from bottle to bottle is the published purity, the testing, the guarantee and the price.

Is 500 mg enough, or do I need 1,000 mg?

Trials used both. In the 4-month trial in middle-aged adults, 500 mg a day improved leg muscle strength compared with placebo. 500 mg is also the daily amount Timeline recommends for Mitopure.

Why pay more than a cheaper bottle?

Two bottles here cost less per day at time of writing: Perpetua.Life at $1.97 and Aeternum at $2.16. Each misses 2 of the 4 checks. At $2.30 a day, Omre is the lowest-cost bottle here that passes all 4.

Can I take urolithin A with medication?

If you take prescription medication, ask your doctor first, especially for blood thinners or statins. Don't use Omre Urolithin A if you're pregnant, nursing, or under 18.

Do I have to subscribe?

No. One bottle is $69 as a one-time purchase. Subscribe & Save takes 5% off a 1-month plan, 10% off 3 months and 20% off 6 months. Cancel, skip or pause anytime.

How long until I notice a difference?

The strength trial ran for 4 months. Timeline also recommends at least 4 months for Mitopure. Plan on 2 capsules a day, with food, for at least that long.

The bottom line