Every bottle promises 500 mg. The one worth buying can prove it reached the capsule.

You've read about mitophagy. You've seen Mitopure's price. You've opened more tabs.

Now you're looking for the best urolithin A supplement of 2026, and every label says the same two things: 500 mg, highly pure.

We make one of these.

So we held all five to the same four checks we built ours to pass. The checks first, so you can run them on any bottle. Then the ranking.

What most labels leave out

Urolithin A is made by your gut bacteria from compounds in pomegranate.

Most people don't make much. In a 100-person study, 12% had detectable urolithin A at baseline, and about 40% produced it after pomegranate juice. A direct 500 mg dose raised levels in everyone, with more than 6 times the exposure of juice.

That's why you buy it in a capsule. The question is what's in the capsule.

The human trials dosed 250 mg to 1,000 mg a day, for 4 weeks to 4 months, and the results came at 500 mg and above.

A lab report turns the number on the front of the bottle into a receipt.

The 4 checks that matter

Rank by checks passed. Break ties on cost per day at 500 mg. Prices are at time of writing, October 2026.

How the top 5 compare

Swipe the table sideways to see every column →

Cost per day is one bottle's price divided by its servings, for example $69 ÷ 30 days.

Best urolithin A supplements 2026, ranked

1. Omre Urolithin A: passes all four checks

2. Toniiq Urolithin A Complex 99.4%: lowest cost, blended label

3. Codeage Liposomal Urolithin A: close formula, no report

4. ProHealth Full Spectrum Urolithin A: longest guarantee, partial report

5. Timeline Mitopure Softgels: the known name, no numbers

The proof behind our #1

Every batch of Omre Urolithin A is independently third-party tested for dose, purity and contaminants, and the certificate is on the product page.

It's made in the USA in a GMP-certified, FDA-registered facility.

Omre was founded by Dr. Pedram Kordrostami, a London-trained medical doctor who practiced in the NHS. Founded by a doctor, for his family.

It's HSA/FSA eligible through Truemed, with a 30-day money-back guarantee.

Asked what changed, reviewers pick energy first, then focus, physical performance and recovery. In their words:

"Excellent product; after 4-6 weeks of consistent use the recovery after work outs was noticeably shorter." — Scott K., verified buyer

"I've taken other mitochondria support supplements but didn't feel a real change. I have to say, I do feel more energized since starting this supplement." — Sarah P., verified buyer

Start with one bottle, backed by 30 days →

Questions before you buy

Is urolithin A safe with my medications?

If you take prescription medication, including blood thinners or statins, ask your doctor before starting. The label says do not use if you are pregnant, nursing or under 18. In the human trials, 500 mg and 1,000 mg a day were well tolerated for up to 4 months.

Why pay more than the lowest-priced bottle?

The lowest-priced verified option here is $1.17 a day, inside a blend whose other amounts aren't itemized on the page. Omre is $2.30 a day for one ingredient, 500 mg, with a batch report that shows 262 mg per capsule and the heavy metals panel. You're paying for a number you can check.

Do I have to subscribe?

No. One-time purchase is $69. Subscribe & Save takes 5% off a 1-month supply, 10% off 3 months and 20% off 6 months, and you can cancel, skip or pause anytime.

Is pomegranate the best source of urolithin A?

Pomegranate supplies the precursor, and your gut bacteria do the converting. In the 100-person study, about 40% converted it after pomegranate juice, and a direct 500 mg dose gave more than 6 times the exposure. A capsule of urolithin A itself skips that step.

How long before I notice anything?

The strength result came at 4 months. Omre reviewers describe changes between 2 weeks and 3 months. Plan on a full bottle before you judge it.

The bottom line