9 Best Senolytic Supplements for Healthy Aging

What Are Senolytic Supplements?

Senolytic supplements are compounds that may help the body clear senescent cells, sometimes called zombie cells, which build up as we age. These cells no longer divide but remain active and release inflammatory signals that can stress nearby healthy cells.

Research has found that senescent cells increase with age and are linked to chronic inflammation and tissue dysfunction (1). By targeting these cells, senolytics may support healthier cellular environments rather than stopping aging itself.

Senolytics can be synthetic or natural. Most supplements focus on plant-derived compounds found in foods such as fruits, vegetables, tea, and spices. 

These natural options are being studied because they appear to act more gently and may be better suited for long-term use.

How Senolytics May Support Cellular Health

As cells age, some enter senescence as a protective response. The problem is that these cells do not always clear out on their own. Over time, they can contribute to low-grade inflammation throughout the body.

Research has reported that certain natural compounds can trigger programmed cell death in senescent cells while leaving healthy cells largely unaffected (2). This selective action is what makes senolytics different from general antioxidants.

Potential ways senolytics may support cellular health include:

• Reducing inflammatory signals released by senescent cells

• Supporting healthier tissue function over time

• Helping the body maintain a better balance between damaged and healthy cells

Most of this evidence comes from laboratory and animal research, with early human data continuing to emerge. For that reason, senolytics are best viewed as supportive tools rather than standalone solutions.

Best Natural Senolytic Supplements Based on Research

Several plant-based compounds have been studied for their ability to target senescent cells and support healthier aging. Below are the natural senolytic supplements most often discussed in current research, explained in a clear and practical way.

1. Fisetin

Fisetin is a flavonoid found in small amounts in foods like strawberries, apples, and persimmons. Among natural senolytics, fisetin has received significant attention because of its selective action on senescent cells.

Research has found that fisetin was able to reduce senescent cell burden in multiple tissues while leaving healthy cells largely unaffected. In animal models, fisetin supplementation was associated with improved tissue function and extended lifespan (2). 

These effects were seen at higher doses than what is typically obtained from food alone, which is why fisetin is often studied in supplement form.

Early human research is still limited, but fisetin is considered one of the more promising natural senolytic candidates based on its consistent results across preclinical studies.

2. Quercetin

Quercetin is another well-studied flavonoid found in apples, onions, and leafy greens. It has long been researched for its antioxidant and anti-inflammatory properties, but it is also known for its senolytic activity.

Research has reported that quercetin can help trigger programmed cell death in senescent cells by interfering with survival pathways that allow these damaged cells to persist (3). 

Quercetin has often been studied alongside other senolytic agents, including pharmaceutical compounds, where it appeared to enhance senescent cell clearance.

Quercetin is generally well tolerated, though like most senolytics, it is typically studied in structured doses rather than continuous high intake.

Combining fisetin and quercetin:

Research suggests that fisetin and quercetin may work through overlapping but slightly different cellular pathways. When used together, they may support broader senescent cell targeting than either compound alone (4).

This is why many senolytic protocols combine the two. At Omre, our Quercetin + Fisetin formula was designed around this complementary relationship, focusing on research-informed dosing and ingredient purity rather than complex blends.

3. EGCG from Green Tea

Epigallocatechin gallate, commonly called EGCG, is a polyphenol found in green tea. It has been studied for its role in cellular stress responses and inflammation.

Research has found that EGCG may help limit the survival of senescent cells by influencing pathways involved in oxidative stress and apoptosis (5). It also appears to reduce inflammatory signaling associated with senescent cell accumulation.

While green tea is a natural source of EGCG, supplements are often used in research to reach consistent intake levels. Higher doses should be approached cautiously, as excessive intake has been linked to liver stress in some individuals.

4. Piperlongumine

Piperlongumine is a compound extracted from long pepper. It has drawn attention for its ability to increase oxidative stress specifically within senescent cells.

Research has reported that piperlongumine can selectively induce cell death in senescent cells while sparing normal cells, at least in laboratory settings (6). This targeted stress response is what gives it potential senolytic activity.

Because this mechanism relies on oxidative stress, dosing appears to matter. Human safety data is still limited, so piperlongumine is generally discussed as a developing area of senolytic research rather than a first-line option.

Quercetin + Fisetin

Quercetin and Fisetin help manage 'zombie' senescent cell burden and support cellular rejuvenation.*

Shop Quercetin + Fisetin

Shop Quercetin + Fisetin

5. Apigenin

Apigenin is a flavonoid commonly found in chamomile, parsley, and celery. It has been studied for its calming, anti-inflammatory, and cell-protective effects.

Research suggests that apigenin may help suppress inflammatory pathways linked to senescent cells (7). By reducing chronic low-grade inflammation, it may indirectly support healthier cellular environments as we age.

Apigenin is commonly consumed as chamomile tea, though supplements are sometimes used to reach amounts studied in research settings.

6. Curcumin

Curcumin is the active compound in turmeric and is widely known for its anti-inflammatory properties. In the context of senescence, curcumin has been studied for its effects on oxidative stress and inflammatory signaling.

Research has found that curcumin may help reduce markers associated with cellular senescence and improve tissue function in aging models (8). Its effects appear to be more supportive than aggressive, making it a gentler option.

One important factor with curcumin is absorption. Studies consistently report better results when curcumin is paired with piperine, which can increase bioavailability significantly.

7. Oleuropein

Oleuropein is a polyphenol found in olive leaves and extra virgin olive oil. It has been studied for its antioxidant and cell-protective properties.

Research suggests that oleuropein may support the removal of senescent cells and help reduce oxidative damage in aging tissues (9). It also appears to support cardiovascular and metabolic health, which often decline with age.

While olive oil provides small amounts, supplements are typically used to reach levels explored in research.

8. Hydroxytyrosol

Hydroxytyrosol is another olive-derived compound and is considered one of the most potent natural antioxidants found in the human diet.

Research has reported that hydroxytyrosol may support mitochondrial function and reduce oxidative stress, both of which are closely linked to cellular aging (10). By supporting healthier energy production, it may help cells better manage age-related stress.

Hydroxytyrosol is often discussed alongside oleuropein because they naturally occur together in olive products and appear to complement each other.

9. Resveratrol

Resveratrol is found in grapes, berries, peanuts, and red wine. It has been widely studied for its effects on longevity-related pathways, including sirtuin activation.

Research has found that resveratrol may reduce the inflammatory secretions associated with senescent cells, known as the senescence-associated secretory phenotype (11). This may help limit tissue damage linked to cellular aging.

At higher concentrations, resveratrol has been shown to stress cells, which is why moderate dosing is commonly emphasized in research.

Resveratrol is often paired with NAD-focused supplements. At Omre, our NMN + Resveratrol formula reflects this relationship by supporting both cellular energy pathways and longevity-related signaling in a balanced way.

Final Words

Senolytic supplements are gaining attention because they focus on one specific part of aging, the buildup of senescent cells and the inflammation they create. 

Research so far suggests that certain plant-based compounds, such as fisetin, quercetin, curcumin, and resveratrol, may help support healthier cellular environments when used thoughtfully. 

Most of the evidence comes from laboratory and animal research, with early human data still developing, which is why senolytics are best seen as part of a broader, long-term approach to healthy aging.At Omre, we focus on science-led formulations and research-informed dosing. Our Quercetin + Fisetin was created around the complementary relationship between these two compounds, without unnecessary fillers or overstated claims. 

We also developed NMN + Resveratrol to support cellular energy and longevity-related signaling, which may work alongside senolytic strategies for people focused on long term cellular health.

FAQs

What is the most effective natural senolytic supplement?

Fisetin and quercetin are often highlighted because research has consistently shown senolytic activity in aging models. They are commonly discussed together because they appear to act through complementary cellular pathways.

Can senolytic supplements really remove senescent cells?

Research has found that certain compounds can trigger programmed cell death in senescent cells, mainly in lab and animal studies. Human research is still limited, so results may vary between individuals.

Is it better to take quercetin and fisetin together?

Studies suggest that combining quercetin and fisetin may support broader senescent cell targeting than using either alone. This combination is often used in structured senolytic protocols rather than daily use.

How long does it take to notice effects from senolytics?

Senolytic supplements do not work overnight. Any noticeable changes are likely subtle and may take weeks or longer, depending on dosage, cycling, and individual health factors.

Are senolytic supplements safe for long-term use?

Natural senolytics are generally well tolerated when used responsibly, but timing and dose matter. Because research is still evolving, it is a good idea to discuss long-term use with a healthcare professional, especially if you have underlying health conditions.