Best Supplements for Men Over 40: Top Picks for Health & Wellness

Why Supplements Are Important For Men Over 40

As men get into their 40s, certain health changes can sneak up on them. You might notice less energy, a slight dip in muscle strength, or maybe even your stamina isn’t quite what it used to be. Eating a balanced diet goes a long way, but sometimes getting all the nutrients you need just from food is tough. 

This is where adding a few supplements can come in handy.

For instance, vitamin D is great for keeping bones strong, especially as our bodies slowly absorb it from sunlight. Omega-3s are fantastic for heart health and worth monitoring as the years pass. 

A simple protein powder or some creatine can make a difference for anyone looking to maintain muscle mass. It’s all about giving your body extra help where it needs it.

Think of supplements as small ways to stay in your groove, keep your energy up, and feel good without complicating things. Simple, straightforward additions can make a real difference.

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Best Supplements For Men Over 40: Our Top Picks

Certain nutrients become even more essential as men age to maintain energy, muscle health, and overall vitality. Here are some of the best supplements for men over 40, tailored to meet specific needs.

• Best Overall - NMN + Resveratrol - Anti-aging & longevity

• Essential nutrients in one - Men Multivitamins

• Best for bone health - Vitamin D 

• Best for heart health - OMEGA-3 Fatty Acids

• Best for energy and sleep - Magnesium

• Best for energy and sleep - Magnesium

• Best for energy booster and cognitive function - Vitamin B12

• Best for immune support and testosterone boost - Zinc

• Best for digestive health and immune support - Probiotics

• Best for inflammation-fighting and joint support - Turmeric/Curcumin

• Best for support for joints and skin health - Collagen

• Best for energy levels - COQ10

• Best for stress management and hormone balance - Ashwagandha

1. Best Overall - NMN + Resveratrol - Anti-Aging & Longevity

NMN and Resveratrol are making waves in the anti-aging scene, and for good reason. Both of these nutrients work together to keep cells functioning efficiently as we age. 

NMN is known to increase NAD+ levels, which are essential for energy production. However, NAD+ naturally declines with age, meaning reduced energy and slower cellular function.

Resveratrol, another powerhouse, activates enzymes called sirtuins, which help regulate NAD+ and keep cells healthy. 

Research suggests that when NMN and Resveratrol are combined, they offer complementary benefits: NMN boosts NAD+ levels, and Resveratrol activates sirtuins, creating a synergy that supports cellular energy and reduces signs of aging (1).

NMN + Resveratrol supplements deliver 500 mg of each ingredient in two capsules, carefully packed at research-backed doses. The addition of BioPerine® enhances absorption, ensuring your body gets the best possible effect from these nutrients. Think of it as a targeted energy boost for your cells, helping you feel sharp, lively, and youthful.

If you are over 40 and seeking to support energy and vitality with age, NMN + Resveratrol is an excellent option. It’s cost-effective, made with high-quality ingredients, and designed to keep you feeling active and resilient as the years roll on.

2. Essential Nutrients In One - Men Multivitamins

A good multivitamin can be like a daily safety net, covering nutrients that might slip through the cracks, especially as we age. For men over 40, your body may need extra help to keep things running smoothly. 

Getting every nutrient from food alone is difficult, so a solid multivitamin steps in. A study found that supplementing with Vitamin D and K, Magnesium, and Zinc supports immunity, muscle function, and heart health, especially in adults over 40, as maintaining these levels through diet alone can be challenging (2). 

When choosing a multivitamin, look for Vitamin D for bone strength and immunity, Magnesium for muscle and heart health, and Zinc to support immunity and testosterone. B vitamins also help with energy and brain function, keeping you sharp and energized throughout the day.

Adding a multivitamin to your routine makes it easy to support overall health without fuss, helping you feel your best every day.

3. Best For Bone Health - Vitamin D

Vitamin D is a powerhouse for keeping bones and immunity in check, especially for men over 40. It helps your body pull in calcium, which is critical for bone strength and can help ward off osteoporosis. Strong bones, fewer fractures—always a win.

In addition, Vitamin D plays a big role in supporting the immune system, helping your body defend against infections. 

A study revealed that regular Vitamin D intake, around 1,000 to 2,000 IU daily, significantly supports bone density and immune function in adults over 40 by enhancing calcium absorption and reducing fracture risk. (3). 

However, Vitamin D deficiency is surprisingly common, especially if you are indoors a lot or live somewhere with limited sunlight. A lack of it can mean weaker bones, more health risks, and even a harder time fighting off illnesses.

Keeping up with Vitamin D is like adding a little backup support to your body’s natural defenses—simple, but it can make a difference.

4. Best For Heart Health - Omega-3 Fatty Acids

Omega-3 fatty acids are well-known for their heart-friendly and anti-inflammatory benefits, making them a great choice for men over 40. They can help lower triglycerides, keep blood pressure in check, and support heart health—especially useful if heart disease is a concern.

A study found that regular Omega-3 supplementation, particularly EPA and DHA, significantly reduced triglycerides and promoted heart health in adults at risk for cardiovascular issues (4). 

But it doesn’t stop there. Omega-3s also have anti-inflammatory properties, which can help ease joint pain and stiffness and keep you mobile and active. This can be a real plus for anyone feeling creaky after a long day.

Fish oil is a popular source of Omega-3s, especially for the types known as EPA and DHA, which are particularly effective. If fish oil isn’t your thing, algae-based supplements are a solid plant-based alternative with similar benefits.

Omega-3s even support brain function, which may help keep memory sharp as you age. Adding Omega-3s to your routine might be a simple way to help your heart, keep your joints moving, and maintain mental clarity.

5. Best For Energy And Sleep - Magnesium

Magnesium is a real multitasker, especially for men over 40. It’s involved in energy production and muscle function and even helps with sleep. Think of it as a helping hand that keeps you energized during the day and relaxed at night.

By supporting ATP production—the body's main energy source—magnesium can give you a natural boost to feel more alert without jitters. A study found that magnesium supplementation significantly reduced blood pressure in adults, supporting cardiovascular health (5).

Magnesium is great for easing muscle tension and preventing pesky cramps after exercise or even at night. And if sleep quality has been hit or miss, magnesium’s ability to relax the nervous system might be just the ticket.

Regarding heart health, magnesium helps regulate blood pressure and keeps your heartbeat steady, reducing cardiovascular risks. It's a reliable option for muscle support, especially if cramps and stiffness are a regular issue.

Magnesium citrate and glycinate are popular choices if you’re wondering which types to choose. They’re easily absorbed and gentle on the stomach, so you’ll likely feel the benefits without unwanted digestive surprises.

6. Best For Energy Booster And Cognitive Function - Vitamin B12

Vitamin B12 is a powerhouse, especially for men over 40. It’s key for keeping red blood cells healthy, which means better oxygen delivery to your muscles and organs—keeping you feeling strong and energized. 

A study highlighted that adequate B12 intake is essential for maintaining cognitive function and nerve health in older adults. Moreover, B12 supports red blood cell production and helps prevent neurological issues such as numbness and memory decline (6).

B12 is also important for nerve health. It supports a healthy nervous system, helping prevent numbness and tingling. In addition to its physical benefits, B12 is often seen as an energy booster that helps keep you sharp. It converts food into fuel, which can help you stay alert and active. 

For most men, around 2.4 mcg of B12 daily does the trick, but some may need more if they have absorption issues. You can find B12 in tablets, under-the-tongue supplements, or injections, often helpful if your body struggles to absorb it.

NMN + RESVERATROL

Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*

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7. Best For Immune Support And Testosterone Boost - Zinc

Zinc is an unsung hero, especially for men over 40. This mineral significantly strengthens the immune system by helping your body produce the cells it needs to fight infections, so staying on top of your Zinc intake can mean staying healthier and more resilient. 

In fact, a study showed that adequate Zinc intake supports immune cell production and helps maintain testosterone levels, which is crucial for overall hormonal balance as we age (7).

It doesn’t stop there—Zinc is also linked to testosterone production, which naturally tends to dip with age. By helping maintain proper testosterone levels, Zinc can support hormonal balance, keeping you feeling your best.

Zinc’s benefits go beyond immunity and hormones; it’s also important for wound healing and prostate health. It speeds up healing by aiding in cell repair, and in the prostate, Zinc may help reduce the risk of issues like enlargement.

The daily recommendation for men over 40 is around 11 mg, though you might need a little more if you have a deficiency. Zinc gluconate and zinc picolinate are popular forms the body can absorb easily. Adding a bit of Zinc to your routine is a straightforward way to support your health as you age.

8. Best For Digestive Health And Immune Support - Probiotics

Gut health is crucial for maintaining digestion and immunity, especially as men age. As we age, our digestive systems can slow down, sometimes leading to bloating, indigestion, and even a dip in immune strength.

A healthy gut isn’t just about digestion—it’s also your body’s way of breaking down food, soaking up nutrients, and keeping out harmful bacteria. Probiotics can be helpful here. These are live “good” bacteria that help balance out the gut, making digestion smoother and improving nutrient absorption. 

Research found that probiotic strains significantly improve digestive health and support immune function. The study demonstrated that these probiotics help balance gut bacteria, enhance nutrient absorption, and reinforce the gut lining, aiding immune defense (8).

With a well-balanced gut, you’re likely to experience fewer of those everyday digestive issues, plus you’ll get more out of the vitamins and minerals in your food, which is handy as your nutritional needs evolve with age. 

Adding a quality probiotic to your routine is a simple step towards keeping things moving smoothly and healthily.

9. Best For Inflammation-Fighting And Joint Support - Turmeric/Curcumin 

Turmeric, specifically its active compound curcumin, is popular for tackling inflammation and supporting joint health. As men age, joint stiffness and pain can become common, and curcumin works by addressing inflammation at its root.

A study found that curcumin significantly reduces joint pain and inflammation, especially in individuals with osteoarthritis. This research supports curcumin’s ability to ease discomfort and improve joint mobility, making it beneficial for anyone with ongoing aches (9).

Curcumin doesn’t just ease pain—it also supports overall mobility by reducing swelling in the joints, helping you stay active without too much discomfort. For men over 40, this can mean keeping up with an active lifestyle while supporting your joints.

When picking a curcumin or turmeric supplement, look for one with BioPerine® (black pepper extract) or liposomal curcumin, as curcumin doesn’t absorb well. These additions help your body get the most out of each dose, making it an effective way to manage inflammation and keep you feeling flexible.

10. Best For Support For Joints And Skin Health - Collagen 

Collagen is the backbone that keeps joints flexible and skin firm. As a building block for connective tissues, it helps maintain joint strength and skin elasticity. However, as men age, collagen levels tend to dip, leading to stiffer joints, less mobility, and the arrival of wrinkles and sagging skin.

Adding collagen to your routine can help replenish what’s naturally lost with age. A study demonstrated that collagen supplementation improved joint comfort and mobility, particularly for those with activity-related joint pain (10).

For men, collagen can mean better joint health and smoother movement, plus the perk of hydrated, more elastic skin, helping to reduce wrinkles and fine lines. Types I and II are most helpful when looking for collagen. Type I supports skin health, while Type II is ideal for joint support.

Hydrolyzed collagen and collagen peptides are popular options because they’re already broken down for easy absorption and mix well into drinks or smoothies, making them convenient additions to your day.

11. Best For Energy Levels - Coq10

CoQ10, or Coenzyme Q10, plays a key role in keeping your heart healthy and your energy levels steady. It helps your cells produce ATP, responsible for everything from muscle movements to heartbeats. However, as men age, natural CoQ10 levels begin to decline, impacting energy and heart health.

For men, especially those taking statins to lower cholesterol, CoQ10 is even more important. Statins can reduce the body’s CoQ10 levels, often leading to fatigue and muscle discomfort. 

A study found that CoQ10 supplementation significantly improved energy levels and reduced muscle discomfort in individuals taking statins. This research highlights CoQ10’s role in supporting cellular energy and mitigating some of the side effects associated with statins, like fatigue and muscle pain, making it especially beneficial for heart health (11).

If you’re considering a CoQ10 supplement, look for Ubiquinol, the active form of CoQ10, which is more readily absorbed by the body. Ubiquinol in soft gels or liquid capsules works better than regular tablets. 

Adding CoQ10 to your daily routine is a straightforward way to help protect your heart and maintain energy as the years go by. It’s a small step with noticeable benefits.

12. Best For Stress Management And Hormone Balance - Ashwagandha 

Ashwagandha is a well-loved adaptogen, especially for men over 40 looking to manage stress and keep their hormones balanced. It helps reduce cortisol, the main stress hormone, making it easier for the body to handle daily pressures and keep stress in check.

A study reveals that Ashwagandha supplementation significantly reduced stress by lowering cortisol levels, helping individuals better manage stress and improve overall well-being (12).

This can also support healthy testosterone levels, which often decline with age. Ashwagandha doesn’t just help with stress—it’s also known for improving energy, mental clarity, and even sleep. 

Many men find they feel more relaxed yet focused, making it easier to manage the demands of work and everyday life. Calming the nervous system can also contribute to a better night's rest and feeling less drained.

If you’re considering adding Ashwagandha to your routine, a daily dose of 300-600 mg is often recommended. It is available in capsule and powder form. 

Consistent use is the way to go, as Ashwagandha’s adaptogenic benefits build up over time, naturally supporting stress and hormone balance.

Tips For Choosing The Right Supplements

Choosing the right supplements can make a noticeable difference in your health routine, but it helps to know what to look for. Here are some handy tips:

• Identify your needs: Start with your goals and any specific health concerns, whether heart health, joint support, or energy. Your age and lifestyle also play a role in determining what might work best for you.

• Look for quality: Pick supplements that have been third-party tested or certified. This helps ensure that what’s on the label is what you’re getting—no unpleasant surprises.

• Choose bioavailable forms: Some forms absorb better than others. For example, magnesium glycinate or CoQ10 in the Ubiquinol form is known for being more easily absorbed.

• Skip the fillers. Choose products without unnecessary artificial additives, colors, or preservatives. Less is more when it comes to quality ingredients.

• Consult a pro: If you’re on medications or have existing health conditions, it’s smart to chat with a healthcare professional before starting something new.

• Check dosage and serving size: Ensure you get an effective dose without going overboard. It’s all about balance.

• Read reviews: Customer feedback can be useful. Check reviews for insights on effectiveness, side effects, and overall quality.

Finding the right supplement doesn’t have to be overwhelming—just a few thoughtful choices can help you get the most out of your supplements.

Conclusion

In summary, supplements are essential in supporting men's health over 40 by addressing concerns like energy, heart health, and hormone balance. Key options such as Omega-3s, Vitamin D, CoQ10, and Ashwagandha can enhance overall wellness and help maintain vitality. Choosing the right supplements involves considering your individual needs, opting for high-quality products and focusing on bioavailable forms for better absorption.

Making informed choices can boost your health and energy as you age. Explore our NMN + Resveratrol supplement to support cellular energy and longevity today.

FAQs

Why Are Supplements Important For Men Over 40?

As men age, their bodies may not absorb nutrients as effectively, and specific health concerns like reduced energy, joint pain, and cardiovascular issues become more common. Supplements help fill these nutritional gaps and support overall health and vitality.

Which Supplements Boost Energy Levels In Men Over 40?

CoQ10, Vitamin B12, and Ashwagandha are excellent for boosting energy and maintaining mental clarity. They support cellular energy production and hormone balance.

How Do Omega-3 Fatty Acids Benefit Heart And Joint Health?

Omega-3s help lower triglyceride levels, reduce inflammation, and support heart function. They also improve joint mobility by reducing stiffness and pain, making them great for cardiovascular and joint health.

What Are The Best Supplements For Supporting Hormone Balance, Particularly Testosterone?

Ashwagandha and Zinc are key supplements for balancing hormones and supporting healthy testosterone levels, especially in men over 40.

What Should I Consider When Choosing A Supplement?

Focus on your specific health needs, opt for high-quality, third-party-tested supplements, and select bioavailable forms that your body can easily absorb, like Ubiquinol for CoQ10 or magnesium glycinate.