Published: April 14, 2025
Last Updated: September 16, 2025
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Best Form of NAD Supplement: What Science Really Says
Published: January 8, 2021
Last Updated: January 19, 2024
Evidence based
3 min read
Best Form of NAD Supplement: What Science Really Says
Written & fact checked by
The Question Everyone Asks
Why NAD Matters
The Options Compared
Liposomal Supplements
NAD Injections
OMRE'S Complete NAD Booster
Why OMRE is Different?
The Question Everyone Asks
“The answer is simple: not NAD+ itself. NAD+ is too large to be absorbed directly into your cells. The most effective approach is to take a precursor like NMN or NR, which your body can convert efficiently into NAD+. And the best way to take these precursors is in capsule or powder form — not IV injections or liposomal formats.”
- Dr. Pedram Kordrostami M.D.
Why NAD Matters
NAD+ is a molecule found in every cell of your body. It’s essential for:
Converting food into energy
Repairing damaged DNA
Supporting healthy cellular function
The problem? NAD+ levels decline steadily with age. By middle age, you may have less than half the NAD+ you did in youth. This drop has been linked to lower energy, slower recovery, and reduced resilience.
That’s why people are searching for the best form of supplement to restore NAD+
The Options Compared
1. Oral Capsules or Powder (Best Option)
This is where all the research has been done — and the results are clear.
NMN studies:
A 2022 trial found that 300mg of NMN raised NAD+ levels in healthy adults by 38%.
A 12-week study in overweight adults showed NMN supplementation improved muscle performance and boosted NAD+.
NR studies:
A 2016 study showed NR at 100–300mg per day increased NAD+ in a clear dose-dependent way.
A 2020 study found NR doubled NAD+ levels in middle-aged and older adults after six weeks.
These human trials confirm that oral NMN and NR in capsule or powder form are proven to work.
Liposomal Supplements
Some brands promote liposomal delivery, but here’s the truth:
Not necessary for NAD precursors. NMN and NR are water-soluble and absorb well in standard capsule or powder form.
Liposomal is best for fat-soluble molecules (like curcumin from turmeric or berberine), not water-soluble ones.
Questionable claims. Liposomal technology is complex — yet many raw ingredient suppliers simply mix some fat into the powder and market it as “liposomal,” with no proven benefit.
Bottom line: liposomal NAD precursors don’t make scientific sense.
Taken together, the evidence shows that the best way to raise NAD+ is not by taking NAD directly, but by taking precursors like NMN.
NAD Injections
Clinics often promote NAD+ injections, but:
No evidence they work. There are no published human studies proving injections raise NAD+.
NAD+ is too large. Even if injected, it struggles to cross into cells.
Expensive and invasive. Sessions often cost hundreds of dollars and must be repeated regularly.
That’s why I don’t recommend injections.
The Verdict: The best form of NAD supplement is clear: oral NMN or NR in capsule or powder form.
This is where the research is strongest, with multiple human trials proving they reliably raise NAD+ levels
Liposomal formats don’t make sense for water-soluble molecules like NMN and NR.
Injections are expensive, invasive, and unproven.
OMRE'S Complete NAD Booster
At OMRE, we’ve formulated a supplement designed to target NAD+ through multiple pathways:
500mg NMN — pure, tested, and efficiently absorbed by the body.
500mg Micronized Resveratrol — activates sirtuins, longevity proteins that stimulate NAD+ production
5mg BioPerine® — boosts Resveratrol absorption by up to 13x.
This isn’t just NMN — it’s a complete NAD booster that delivers results backed by science.
Shop NMN + Resveratrol
Why OMRE Is Different?
At OMRE, quality is non-negotiable.
We use the highest quality ingredients available on the market.
We test the raw NMN powder and then test it again after the product is encapsulated. Every batch is tested twice.
The finished product also undergoes testing for heavy metals, fungi, and bacterial contamination.
All supplements are manufactured in the USA in a GMP-certified facility.
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