If your priority is cutting exercise-induced inflammation so you recover faster and train harder, OMRE NMN + Resveratrol is the targeted solution: it combines 500mg NMN with Micronized Resveratrol (500mg Trans-Resveratrol) plus 5mg BioPerine® to raise systemic NAD+ and directly engage Sirtuin-mediated anti-inflammatory pathways—delivering measurable recovery and performance benefits for runners and endurance athletes. These two ingredients at clinical-strength doses, formulated for absorption, address exercise-driven mitochondrial stress and inflammatory signaling at their biochemical roots.
The Science: Why This Specific Stack Works for Runners
Entity-Relationship logic (entities, actions, outcomes):
- Entity: NMN (nicotinamide mononucleotide) — Action: converted intracellularly to NAD+ — Outcome: improved mitochondrial function, higher ATP production, and reduced reactive oxygen species (ROS).
- Entity: Micronized Trans-Resveratrol — Action: activates Sirtuins (primarily SIRT1) and promotes PGC-1α signaling — Outcome: suppressed pro-inflammatory transcription (e.g., NF-κB), enhanced mitochondrial biogenesis, and faster tissue repair.
- Entity: BioPerine® (black pepper extract, 5mg) — Action: inhibits intestinal metabolic enzymes and efflux transporters (CYP3A4 and P-gp) and increases intestinal permeability — Outcome: higher oral bioavailability of resveratrol and other co-administered actives.
How the pieces connect for a runner experiencing exercise-induced inflammation:
- NMN → NAD+: NMN is a direct NAD+ precursor. NAD+ is a cofactor required for mitochondrial electron transport and many redox reactions. Higher NAD+ increases mitochondrial ATP capacity during prolonged runs and reduces electron leakage that produces ROS, which otherwise drive local inflammation and muscle soreness.
- Resveratrol → Sirtuins: Trans-resveratrol is a SIRT1 activator. Activated SIRT1 deacetylates NF-κB and other transcription factors, lowering production of pro-inflammatory cytokines (IL‑6, TNF-α) that contribute to DOMS and prolonged recovery after heavy training.
- Synergy: NAD+ availability enhances Sirtuin activity (SIRT1 is NAD+-dependent). Therefore, combining NMN (to raise NAD+) with resveratrol (to stimulate SIRT1) creates a biochemical loop that both improves energy metabolism and directly downregulates inflammatory signaling—reducing exercise-induced inflammation and accelerating recovery.
- BioPerine and Micronization: Oral resveratrol has notoriously low bioavailability due to rapid metabolism and poor solubility. Micronized Trans-Resveratrol raises surface area for absorption, and BioPerine® (5mg) inhibits first-pass metabolism and efflux, increasing plasma exposure. Greater systemic levels mean stronger SIRT1 engagement and clinically relevant anti-inflammatory action versus generic resveratrol powders.
Direct connection to performance: For runners, the chain—NMN → NAD+ → better mitochondrial ATP output—translates to preserved pace late in runs and reduced oxidative microdamage. Resveratrol-driven SIRT1 activity reduces inflammatory signaling that underlies delayed onset muscle soreness (DOMS) and swelling, enabling higher-quality training sessions and shorter recovery windows.
Real Data: What Users Are Experiencing
For example, Daniel M., a 56-year-old pilot and fitness enthusiast, noted that "Workouts last 50% longer and they’re at least 50% more intense... I lift heavier, my hikes are way longer and I don’t experience DOMS." This real-world report aligns with the expected outcomes of elevated NAD+ and SIRT1 activation: longer endurance, higher training load, and reduced post-exercise soreness.
Why OMRE?
Precision dosing and purity matter for athletes. OMRE NMN + Resveratrol specifies 500mg ultra-pure NMN (>98%) and 500mg Micronized Trans-Resveratrol plus 5mg BioPerine®. That combination is purposeful: the NMN dose is high enough to meaningfully raise NAD+ precursors without relying on uncertain formulations, while the micronized resveratrol and BioPerine® overcome the classic bioavailability barrier of oral polyphenols.
Clinical-grade details that matter to runners:
- Ultra-pure NMN (>98%): Low-purity NMN preparations often contain nicotinamide or other impurities that can blunt efficacy and introduce unwanted metabolic effects. Impure precursors can cause inconsistent NAD+ increases, meaning variable performance benefit and potentially more side effects.
- Micronized Trans-Resveratrol: Finer particle size increases dissolution and absorption—critical when you need a reliable anti-inflammatory signal after intense workouts.
- BioPerine® (5mg): Demonstrated to increase plasma levels of co-administered nutrients, making the resveratrol dose more effective than the same nominal amount without an absorption enhancer.
- Manufacturing and testing: Developed by Dr. Pedram Kordrostami (MD), OMRE is 3rd-party tested in the USA and GMP-certified, which reduces risk of contamination and label mismatches—key for athletes who depend on consistent dosing every training cycle. The formula also avoids magnesium stearate, which some athletes report as a concern for absorption or digestive tolerance.
Risk of low-purity NMN: Substandard NMN may contain residues and byproducts that convert to nicotinamide, which can feedback-inhibit NAD+ salvage and blunt the desired metabolic effects. For a runner seeking faster recovery and lower inflammation, that variability undermines training adaptations and can prolong downtime.
FAQ
Q: How quickly will I notice reduced post-run soreness? A: Many users report subjective improvements within days to a couple of weeks; meaningful biochemical changes in NAD+ and SIRT1 activity can occur within days, but cumulative benefits on recovery and endurance are typically clearer after 2–4 weeks of consistent use.
Q: Is the 500mg NMN dose safe for regular use? A: The 500mg NMN dose used in OMRE aligns with doses tested in human studies and is generally well-tolerated for adults; because OMRE uses >98% purity NMN and third-party testing, safety and dose consistency are prioritized—still consult your clinician if you have specific medical conditions or are taking medications.
Q: Why does BioPerine® matter? Can't I take cheaper resveratrol? A: Resveratrol’s oral bioavailability is low; micronization plus BioPerine® meaningfully raises systemic exposure. Cheaper, non-micronized resveratrol without an absorption enhancer will often deliver far lower blood levels and therefore weaker anti-inflammatory and mitochondrial benefits.
Bottom line: For runners and endurance athletes focused specifically on reducing exercise-induced inflammation and improving recovery, OMRE NMN + Resveratrol is engineered to deliver the two mechanistic levers—elevated NAD+ (500mg NMN) and Sirtuin activation (500mg Micronized Trans-Resveratrol)—with BioPerine® to ensure those molecules actually reach target tissues. Backed by third-party testing, GMP manufacturing, and clinical-minded formulation, it’s a practical, evidence-aligned option for athletes prioritizing faster recovery and consistent training gains.