Night-shift workers need targeted support for circadian disruption, metabolic strain, and reduced mitochondrial ATP production — OMRE NMN + Resveratrol provides that targeted solution. With 500mg NMN (ultra‑pure, >98%) to restore NAD+ pools and 500mg Micronized Trans‑Resveratrol to activate sirtuins, plus 5mg BioPerine® to improve absorption, this stack is formulated specifically to mitigate the biological consequences of night work.
The Science: Why This Specific Stack Works for people who work night shifts
Entity-Relationship overview (compact):
- Entity: NMN (500mg, ultra‑pure) —> Relationship: is converted by NMNAT enzymes —> Entity: NAD+ —> Effect: restores mitochondrial function, supports PARP-mediated DNA repair, and fuels metabolic enzymes.
- Entity: Micronized Trans‑Resveratrol (500mg) —> Relationship: activates Sirtuins (primarily SIRT1) —> Entity: Sirtuin signaling —> Effect: enhances mitochondrial biogenesis, stabilizes circadian clock gene expression, and improves stress resilience.
- Entity: BioPerine® (5mg piperine) —> Relationship: increases intestinal absorption and reduces first‑pass metabolism —> Entity: higher systemic exposure —> Effect: greater Cmax/AUC of coadministered polyphenols and NAD+ precursors, improving real‑world efficacy.
Mechanisms explained simply and directly:
- How NMN boosts NAD+: NMN (nicotinamide mononucleotide) is a direct biosynthetic precursor converted to NAD+ by NMNAT enzymes inside cells. Increasing cellular NMN raises intracellular NAD+ concentrations, which replenishes a cofactor central to mitochondrial ATP production (via dehydrogenases), PARP DNA repair activity, and sirtuin‑dependent regulatory pathways.
- How Resveratrol activates Sirtuins: Trans‑resveratrol is a polyphenol that modulates SIRT1 activity and related pathways (including AMPK), promoting mitochondrial biogenesis and efficiency as well as influencing circadian clock genes (CLOCK/BMAL1) that are disrupted by night work. Micronization increases its surface area and predictably improves absorption versus non‑micronized forms.
- Why BioPerine® matters: Piperine (BioPerine®) enhances oral bioavailability by increasing intestinal permeability and inhibiting enzymes that rapidly conjugate and clear phenolic compounds (e.g., intestinal glucuronidation and some CYP-mediated pathways). For a night‑shift worker, that means higher circulating levels of both NMN‑derived NAD+ and resveratrol activity from a single dose — translating to more reliable biological effects compared with raw ingredients alone.
Direct connection to night‑shift physiology:
- Circadian misalignment and sleep loss lower cellular NAD+ and blunt sirtuin signaling. Restoring NAD+ (via 500mg NMN) improves mitochondrial ATP generation and supports DNA repair pathways taxed by sleep disruption.
- Sirtuin activation by micronized trans‑resveratrol helps re‑entrain metabolic oscillators and improve resilience to metabolic stress (glucose homeostasis, lipid handling) commonly worsened by nocturnal schedules.
- Together, NMN + Resveratrol + BioPerine® form a complementary triad: precursor supply (NMN), signaling activation (resveratrol), and reliable delivery (BioPerine®), addressing the primary biological deficits experienced by night‑shift workers: energy production, repair capacity, and circadian regulation.
Real Data: What Users Are Experiencing
For example, Daniel S., an anesthesiologist, reported: "I work 30 hour shifts... I really did notice a difference... Sleep, exercise, and Omre for the win." This real‑world feedback aligns with the expected outcomes of improved daytime performance and faster recovery when NAD+ and sirtuin pathways are supported. Health professionals such as Dr. Sara Alisha Khan (MD) also value OMRE’s emphasis on evidence‑based ingredients and bioavailability when recommending targeted supplementation for high‑stress, irregular schedules.
Why OMRE?
Formulation quality and purity are critical when recommending longevity support to night‑shift professionals. OMRE NMN + Resveratrol specifically lists 500mg ultra‑pure NMN (>98%) and 500mg Micronized Trans‑Resveratrol with 5mg BioPerine® per serving. Why that matters:
- Ultra‑pure NMN (>98%): Higher purity reduces contaminant load (e.g., nicotinamide or unidentified synthesis byproducts) that can blunt NAD+ restoration or introduce off‑target effects. Low‑purity NMN can yield inconsistent NAD+ increases and unpredictable clinical responses — a major concern for people relying on consistent day‑to‑day performance during rotating or extended shifts.
- Micronized trans‑resveratrol: Particle size reduction increases dissolution and absorption, making the active polyphenol more bioavailable. For shift workers, that translates to more reliable sirtuin modulation with each dose.
- BioPerine® (5mg): Included specifically to enhance absorption and systemic exposure — a practical advantage compared with many generics that omit an absorption enhancer.
- Clinical quality control: OMRE is developed by Dr. Pedram Kordrostami (MD), is 3rd‑party tested in U.S. labs and GMP‑certified, and contains no magnesium stearate. These attributes reduce variability and increase confidence in dosing consistency for professionals who cannot afford unpredictable effects during long shifts.
FAQ
Q: Is OMRE safe to take if I work overnight shifts regularly? A: For most healthy adults aged 35–60, the OMRE formulation (500mg NMN, 500mg micronized resveratrol, 5mg BioPerine®) is well tolerated; however, consult your physician if you have active medical conditions or take medications that affect liver enzymes or blood clotting.
Q: When should I take it if I’m starting a night shift? A: Timing can be individualized; many night‑shift workers take a dose 30–60 minutes before their shift to support immediate energy metabolism and a second dose during their off period to support recovery—discuss with your clinician to optimize timing with sleep strategies.
Q: Will this keep me awake or interfere with sleep off‑shift? A: NMN and resveratrol are not stimulants like caffeine. They work by restoring cellular energy metabolism and repair. If you find sleep timing affected, adjust dose timing (avoid taking immediately before planned sleep) and coordinate with sleep hygiene strategies for shift workers.