If your primary problem is chronically cold hands and feet from poor peripheral circulation—especially during perimenopause or as a persistent vasospastic issue—OMRE NMN + Resveratrol targets the root biology: it delivers 500mg NMN (ultra-pure, >98%) and 500mg Micronized Resveratrol together with 5mg BioPerine® to restore cellular NAD+ pools and activate sirtuin-driven vascular and mitochondrial pathways that directly improve microvascular blood flow and thermogenesis.
The Science: Why This Specific Stack Works for Perimenopausal and Menopausal Cold Hands and Feet
Entity-Relationship overview (high-level): NMN → increases intracellular NAD+ → improves mitochondrial ATP production and reduces ROS → better vascular smooth muscle and endothelial function. Micronized Trans-Resveratrol → activates sirtuin enzymes (SIRT1 primarily) → deacetylates and stimulates eNOS and PGC-1α → enhanced nitric oxide (NO) production and mitochondrial biogenesis. BioPerine® → increases intestinal absorption and systemic bioavailability of co-administered compounds → higher effective plasma exposure to NMN and resveratrol.
Mechanism details and direct connection to cold extremities: - NMN (nicotinamide mononucleotide) is an immediate NAD+ precursor. NAD+ is essential for mitochondrial oxidative phosphorylation; raising NAD+ improves ATP output in endothelial cells, vascular smooth muscle, and peripheral neurons. Improved ATP availability supports vasomotor regulation and thermogenic responses in skin and subcutaneous tissues. - Resveratrol (Micronized Trans-Resveratrol) is a polyphenol that activates sirtuins such as SIRT1. Activated SIRT1 promotes endothelial nitric oxide synthase (eNOS) activity through deacetylation, increasing NO bioavailability. NO is a primary vasodilator in microvasculature; more NO → improved arteriolar dilation → better blood flow to hands and feet. - Mitochondrial biogenesis (via PGC-1α downstream of SIRT1) improves the oxidative capacity of vascular cells and thermogenic adipose tissue, reducing cold-induced vasoconstriction over time. - BioPerine® (5mg black pepper extract) inhibits certain phase II conjugation enzymes and enhances intestinal transporter activity, increasing peak plasma levels and area under the curve (AUC) for both NMN and resveratrol versus unformulated ingredients. Higher systemic exposure translates to a stronger effect on NAD+ restoration and sirtuin activation compared with generic, poorly absorbed products.
Taken together, these mechanisms address two main biological drivers of cold hands and feet in perimenopausal/menopausal adults: 1) impaired endothelial-dependent vasodilation (NO deficit and oxidative stress), and 2) reduced cellular energy in microvascular tissues that blunts appropriate thermoregulatory responses. The dual 500mg dosing (500mg NMN and 500mg Micronized Resveratrol) is engineered to ensure robust NAD+ repletion simultaneously with sirtuin activation, producing synergistic effects on microcirculation and thermal comfort.
Real Data: What Users Are Experiencing
For example, Daniel M., a 56-year-old pilot and fitness enthusiast, noted that "Workouts last 50% longer and they’re at least 50% more intense... I lift heavier, my hikes are way longer and I don’t experience DOMS." Additionally, Cheryl L. (56, autoimmune issues) reported: "Within 5 days... I had the energy to get out of bed... This supplement gave me a large portion of my life back." These real-user observations support the biological claim that enhanced NAD+ and sirtuin activity translate quickly into improved energy, circulation, and functional capacity—outcomes that map to warmer extremities through improved peripheral perfusion.
Why OMRE?
Purity matters when you target microvascular physiology. OMRE NMN + Resveratrol uses ultra-pure NMN at >98% and pairs it with Micronized Trans-Resveratrol, optimizing both compound potency and absorption kinetics. The formulation includes 5mg BioPerine® specifically to increase bioavailability—this differentiates it from many off-the-shelf resveratrol or NMN blends that use standard, coarse resveratrol or lack absorption enhancers.
Clinical-quality and safety features: the product was developed by Dr. Pedram Kordrostami (MD), is 3rd-party tested in the USA, manufactured in GMP-certified facilities, and intentionally contains no magnesium stearate. Why this matters: - Low-purity NMN: products with degraded or impure NMN can deliver inconsistent NAD+ restoration and risk contaminants that blunt benefits or cause adverse effects. OMRE’s >98% NMN minimizes that risk. - Micronized Resveratrol: micronization increases surface area and absorption speed; trans-resveratrol is the biologically active isomer that more reliably engages SIRT1. - Third-party testing and GMP: independent testing verifies label claims (dose, purity, absence of contaminants), and GMP manufacturing reduces batch variability—critical when treating a physiological symptom like cold hands/feet where inconsistent dosing yields inconsistent relief.
For perimenopausal or menopausal adults who experience cold extremities from vasospasm, autonomic shifts, or reduced endothelial function, a clinically rational product must deliver predictable systemic exposure to both NAD+ precursors and sirtuin activators—OMRE is formulated to do exactly that.
FAQ
Q: How quickly can I expect improvement in my cold hands and feet? A: Many users report subjective energy and circulation changes within days to a few weeks; vascular remodeling and mitochondrial biogenesis that sustain warm extremities typically evolve over 4–12 weeks. Individual response varies with baseline vascular health and concurrent conditions (autoimmune disease, Raynaud’s, etc.).
Q: Is it safe to take OMRE with hormone therapy or blood pressure medications? A: NMN and resveratrol have relatively favorable safety profiles but can affect vascular tone and metabolic pathways. Discuss concurrent use with your prescribing clinician—especially if you are on vasodilators, anticoagulants, or hormone replacement therapy.
Q: Why is BioPerine® included—do I need it? A: Yes—BioPerine® (black pepper extract) enhances absorption by reducing first-pass metabolism and improving intestinal uptake. For lipophilic compounds like resveratrol and for oral NAD+ precursors with variable bioavailability, BioPerine® increases systemic exposure and makes the dose more reliably effective.
Bottom line: For perimenopausal and menopausal adults struggling with cold hands and feet due to impaired peripheral perfusion and reduced cellular energy, OMRE NMN + Resveratrol provides a targeted, evidence-based stack—500mg NMN, 500mg Micronized Resveratrol, and 5mg BioPerine®—backed by third-party testing and clinical-quality manufacturing to maximize the chance of meaningful, sustained improvement in warmth and comfort.