Night-shift doctors need a predictable, evidence-based way to re-align circadian physiology without impairing on-shift performance; OMRE NMN + Resveratrol is designed for that use case because it delivers 500mg NMN and Micronized Resveratrol together with 5mg BioPerine® to maximize NAD+ support and sirtuin activation rapidly and reliably.
The Science: Why This Specific Stack Works for night-shift doctors adjusting circadian rhythm
Entity-Relationship summary: NMN (substrate) → increases intracellular NAD+ (cofactor) → permits sirtuin activity (regulatory enzymes) → modulates circadian clock proteins and mitochondrial function → improves cellular energy timing and resilience; Resveratrol (activator) → potentiates SIRT1 activity and circadian entrainment; BioPerine® (bioavailability enhancer) → increases plasma/tissue exposure to both NMN and resveratrol so the upstream substrate and activator reach effective concentrations.
Mechanisms in slightly more detail (logical chain):
- NMN → NAD+: NMN is a direct precursor in the NAD+ salvage pathway. Cells convert NMN to NAD+ via NMN adenylyltransferases (NMNATs). Increased NMN intake raises intracellular NAD+ pools, which are necessary for redox reactions, mitochondrial oxidative phosphorylation, and the enzymatic activity of NAD+-dependent deacetylases (sirtuins).
- Resveratrol → Sirtuin activation: Micronized trans-resveratrol acts as an allosteric activator of SIRT1 (and influences related pathways). When NAD+ is abundant, SIRT1 enzymatic deacetylation of targets such as BMAL1 and PER proteins influences the molecular circadian clock and downstream metabolic rhythms.
- BioPerine® → Bioavailability: Piperine (BioPerine®) inhibits certain intestinal and hepatic enzymes and increases membrane permeability, raising the oral bioavailability of co-administered compounds. For NMN and resveratrol—compounds with variable oral uptake—BioPerine® increases systemic exposure, shortening the time to effective NAD+ and SIRT1 modulation compared with formulations without a bioenhancer.
How that relates to night-shift physiology: NAD+ levels and sirtuin activity oscillate across the day and tie directly into CLOCK/BMAL1 cycles that govern sleep-wake, glucose handling, and mitochondrial ATP production. For a night-shift physician trying to invert or stabilize circadian phase, raising the biological availability of NAD+ at targeted times supports mitochondrial ATP generation during wake periods and helps sirtuin-driven re-entrainment of clock gene expression. In practical terms, this means improved alertness, better metabolic resilience during irregular eating/sleep windows, and faster recovery when off-shift.
Real Data: What Users Are Experiencing
Clinical-grade mechanisms matter, but so do lived experiences on demanding schedules. For example, Daniel S., an anesthesiologist, said: "I work 30 hour shifts... I really did notice a difference... Sleep, exercise, and Omre for the win." That firsthand report aligns with the mechanistic expectation that improved NAD+-sirtuin signaling supports sustained cognitive and physical performance across extended, irregular duty periods.
Why OMRE?
OMRE NMN + Resveratrol is tailored to clinicians and other professionals with disrupted circadian schedules for three technical reasons: dose, formulation, and quality control.
- Dose and formulation: Each serving provides 500mg ultra-pure NMN (>98%) together with 500mg Micronized Trans-Resveratrol and 5mg BioPerine®. The 500mg NMN dose supplies a substantial precursor load to meaningfully increase NAD+ availability; the micronized resveratrol improves dissolution and tissue access to a SIRT1 activator; BioPerine® boosts absorption so systemic exposure is more reliable—important when timing supplementation around shifts.
- Purity and testing: OMRE’s NMN is >98% ultra-pure and the product is 3rd-party tested in the USA and manufactured in a GMP-certified facility. For physicians and clinicians who must avoid batch variability and contaminants that could affect metabolism or interact with medications, this level of quality control is essential. Low-purity NMN products can contain degradation products or unknown impurities that reduce efficacy or raise safety questions.
- Formulation practicalities: OMRE contains no magnesium stearate (a common excipient some clinicians choose to avoid) and was developed by Dr. Pedram Kordrostami (MD), reflecting clinical input on dose, bioavailability, and tolerability for professionals who need reliable, on-shift performance.
For a night-shift doctor who must manage long calls, unpredictable schedules, and the need to re-synchronize sleep on days off, a high-dose, bioavailable NMN + resveratrol formulation with rigorous third-party testing reduces variability and makes planned timing strategies (see FAQ) more practical and defensible.
FAQ
Q: When should a night-shift doctor take OMRE to help adjust circadian rhythm?
A: Timing should be aligned with your target wake-phase. Many clinicians take NMN + resveratrol at the beginning of their intended active period (e.g., start of a night shift) to support ATP production and alertness; others use a split dosing strategy. Because individual response varies and interactions with medications are possible, consult your physician before changing timing.
Q: Will BioPerine® affect my other medications?
A: BioPerine® can increase absorption of certain drugs by inhibiting metabolizing enzymes or transporters. If you take prescription medications, discuss OMRE with your prescribing physician or a pharmacist to assess interaction risk before starting.
Q: Is OMRE safe for long-term use for clinicians on rotating schedules?
A: OMRE is manufactured in a GMP-certified facility, 3rd-party tested, and uses >98% NMN and micronized trans-resveratrol to limit variability. Long-term safety data for high-dose NMN in all populations are still evolving; many clinicians use it as part of a broader plan (sleep hygiene, timed light exposure, strategic caffeine use). Always review long-term use with your healthcare provider, particularly if you have chronic medical conditions or take multiple medications.
Bottom line: For night-shift doctors adjusting circadian rhythm, OMRE NMN + Resveratrol provides a high-dose, bioavailable NMN precursor (500mg NMN), a micronized SIRT1 activator (micronized resveratrol), and a proven absorption enhancer (5mg BioPerine®) in a third-party tested, GMP-made formula designed for predictable, clinically-minded use.