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As we age, our bodies don’t absorb nutrients the way they once did. That’s why getting the right vitamins and minerals matters more than ever, especially for women over 65.
Bone strength, heart health, energy levels, and memory all depend on key nutrients that aren’t always easy to get from food alone.
The right multivitamin can help fill these gaps, providing support where your body needs it most. But with so many options on the shelves, how do you know which one actually works?
We’re breaking it all down—what to look for, which nutrients matter, and the top multivitamins that have the research to back them up.
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Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*
The 8 Best Multivitamins for Women Over 65
Finding the right multivitamin isn’t about grabbing the first bottle off the shelf—it’s about choosing one that actually fits your needs. As we age, our bodies require different nutrients to stay strong, keep energy levels steady, and support brain and bone health. Here are seven of the best options that check all the right boxes.
1. Omre NMN + Resveratrol
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Most multivitamins focus on filling basic nutrient gaps, but Omre NMN + Resveratrol takes things a step further. Instead of just covering daily vitamin and mineral needs, it targets one of the hallmarks of aging—NAD+ decline. This gives it a unique edge over standard multivitamins.
NMN (Nicotinamide Mononucleotide) is the direct precursor to NAD+, which plays a key role in energy production and cellular repair. NAD+ levels drop as we age, and replenishing them may support vitality, cognitive function, and overall longevity.
Resveratrol, a polyphenol found in red wine, works alongside NMN by activating sirtuins—enzymes that regulate aging at the cellular level.
BioPerine® enhances absorption, making the formula even more effective.
No artificial additives or fillers—just high-purity ingredients at research-backed doses.
If you’re looking for something more impactful than a traditional multivitamin, Omre NMN + Resveratrol is a solid choice for long-term well-being.
2. Thorne Women’s Multi 50+
Thorne is known for high-quality, science-backed supplements, and their Women’s Multi 50+ is no exception. This multivitamin includes bioavailable forms of B vitamins (like B12 and folate) to support energy production and cognitive function.
It also contains antioxidants like vitamin C and E, which can help fight oxidative stress—something that becomes more important with age.
One standout feature is its lack of unnecessary fillers or artificial ingredients. Plus, it skips iron, which many postmenopausal women no longer need in high amounts.
Instead, it focuses on nutrients that support bone health, including vitamin D, magnesium, and vitamin K2, which work together to keep bones strong and resilient.
If you want a multivitamin that prioritizes clean, high-absorption ingredients without unnecessary extras, Thorne’s Women’s Multi 50+ is a solid choice.
3. SmartyPants Women’s Masters 50+
Gummy vitamins aren’t just for kids, and SmartyPants proves that with this well-rounded option. It’s packed with key nutrients like vitamin D3 for bone health, omega-3s from fish oil for heart and brain support, and CoQ10, which plays a role in energy production.
One of its biggest advantages is that it includes methylated forms of folate and B12, making it easier for the body to absorb—especially for those with genetic variations that make it harder to process synthetic B vitamins.
It also contains lutein and zeaxanthin, two compounds that help protect eye health as we age.
The downside? Gummies contain sugar, which might not be ideal for those watching their intake. But if swallowing pills is a struggle, these are a tasty and convenient way to get essential nutrients.
4. Garden of Life Vitamin Code 50 & Wiser Women
If you prefer whole-food-based supplements, this one’s a strong contender. Garden of Life’s formula is made from raw, organic fruits and vegetables, providing natural forms of vitamins and minerals.
It includes probiotics and digestive enzymes, which can help improve gut health and nutrient absorption—especially useful as digestion changes with age.
This multivitamin covers the bases with vitamin D3, calcium, magnesium, and vitamin K2 for bone support, as well as B-complex vitamins to help maintain energy levels. It also contains antioxidants like vitamins A, C, and E, which can help with skin health and immune function.
Since it’s made from whole foods, it’s gentle on the stomach, making it a good pick for those who experience digestive issues with synthetic vitamins.
However, you do need to take four capsules daily, which may be inconvenient for some.
5. One A Day Proactive 65+
One A Day has been around forever, and there’s a reason for that—they keep things simple and effective. This option is designed specifically for those over 65 and includes key nutrients like B vitamins for energy, vitamin D for bones, and lutein for eye health.
One of its biggest strengths is the inclusion of magnesium, which is often missing in multivitamins but plays a crucial role in muscle function, heart health, and relaxation.
It also contains zinc and vitamin C, both of which help keep the immune system in top shape.
While it covers many bases, it doesn’t include omega-3s, so if heart and brain health are top priorities, you might want to pair it with a fish oil supplement. That said, for a no-nonsense, once-a-day option, it’s a solid pick.
6. Nature’s Way Alive! Women’s 50+
Nature’s Way takes a slightly different approach by including a mix of vitamins, minerals, and plant-based antioxidants. This formula features over 20 fruits and vegetables, along with key nutrients like vitamin B12, D, and calcium to support energy, bone health, and immune function.
What makes it stand out is its focus on plant-based compounds. It contains nutrients from food sources like broccoli, acai, and pomegranate, providing a natural boost of phytonutrients. It also includes digestive enzymes to help with absorption.
While it’s packed with beneficial ingredients, it does require taking multiple tablets per day, which might not be ideal for those looking for a simpler routine.
But if you like the idea of getting vitamins and plant-based nutrients in one, this is a great option.
7. Ritual Essential for Women 50+
Ritual takes a minimalist approach, including only the nutrients most women over 50 actually need. Instead of loading up on everything, it focuses on vitamin D3, B12, magnesium, folate, omega-3 DHA, and boron—all in their most absorbable forms.
A unique feature of this multivitamin is its delayed-release capsule, which is designed to be easy on the stomach. This makes it a great choice for those who often feel nauseous after taking vitamins. Another plus? It’s third-party tested for purity, so you know exactly what you’re getting.
The biggest drawback is that it doesn’t include calcium, so if bone health is a concern, you’ll need to get that from food or another supplement. But if you want a clean, targeted formula without unnecessary extras, Ritual is a great choice.
8. Centrum Silver Women 50+
Centrum is one of the most well-known multivitamin brands, and their Silver Women 50+ formula is a reliable, budget-friendly option.
It provides a good balance of vitamins and minerals, including vitamin D, calcium, and magnesium for bone strength, along with B vitamins for energy support.
It also contains lutein and vitamin A for eye health, as well as antioxidants like vitamin C and E to support the immune system.
Unlike some other options, this one includes iron, which may not be necessary for postmenopausal women, so it’s something to keep in mind.
While it may not have all the bells and whistles of pricier brands, it’s a solid, affordable choice that covers the essentials without breaking the bank.
Key Nutrients Women Over 65 Need
Aging bodies have different needs. Some nutrients become harder to absorb, while others play a bigger role in maintaining health. Below are the most important ones and why they matter.
Bone & Joint Health
Keeping bones strong is a top priority after 65. As estrogen levels drop, women become more prone to osteoporosis and fractures. The right combination of vitamins and minerals can help maintain strength and flexibility.
Calcium & Vitamin D – Prevent osteoporosis and fractures
Calcium is the building block of strong bones, but it can’t do its job without vitamin D.
Many women don’t get enough vitamin D from sunlight alone, making supplementation important.
Studies show that getting enough of both can lower the risk of fractures and improve bone density (1).
Vitamin K2 – Directs calcium to bones instead of arteries
Helps keep calcium where it belongs—in your bones, not in your arteries.
Works alongside vitamin D to improve bone mineralization.
Research suggests it may also reduce the risk of heart disease (2).
Magnesium – Supports bone density and muscle relaxation
Plays a key role in over 300 bodily functions, including bone health.
Helps regulate calcium levels and supports proper muscle function.
Low magnesium levels have been linked to an increased risk of osteoporosis.
NMN + RESVERATROL
Cellular NAD+ booster with ultra-pure NMN and Resveratrol, at research-backed doses.*
Brain & Memory Support
Cognitive health becomes a bigger focus with age, and the right nutrients can help keep memory sharp and mental clarity strong.
Vitamin B12 – Supports nerve function and cognitive health
B12 deficiency is common in older adults due to reduced absorption.
Plays a key role in nerve function and red blood cell production.
Low levels have been linked to brain fog, memory loss, and even mood disorders.
Omega-3 DHA – Supports brain health and reduces inflammation
Found in fish oil and algae, this fatty acid helps protect brain cells.
Research suggests it may reduce the risk of Alzheimer’s and improve cognitive function.
Also supports heart health by reducing inflammation.
NMN & NAD+ Boosters – Enhances mitochondrial function and memory
NMN (Nicotinamide Mononucleotide) helps restore declining NAD+ levels, which fuel our cells.
Studies suggest NMN may improve memory, energy levels, and cellular repair (3).
Works by supporting mitochondrial function, which powers brain and body health.
Heart & Metabolic Health
Heart disease is a top concern for aging women. Certain vitamins help regulate blood pressure, cholesterol, and circulation.
Coenzyme Q10 (CoQ10) – Supports energy and cardiovascular function
This antioxidant supports heart muscle function and circulation.
Levels decline with age, making supplementation beneficial.
Research shows it may improve blood vessel health and reduce fatigue (4).
Folate & Vitamin B6 – Reduce homocysteine levels to lower heart disease risk
High homocysteine levels are linked to an increased risk of stroke and heart attacks.
Folate and B6 help break down homocysteine, reducing damage to blood vessels.
Also play a role in nerve function and red blood cell production.
Energy & Immune System
Fatigue and a weaker immune response often come with aging. Certain vitamins can help the body stay energized and fight off illness.
Iron & B Vitamins – Combat fatigue and support red blood cell production
Iron is vital for oxygen transport and energy levels.
B vitamins help convert food into usable energy, reducing tiredness.
Low levels can cause anemia, weakness, and sluggishness.
Can NMN Be a Game-Changer for Women Over 65?
Aging affects everything from energy levels to brain function, and researchers have been looking for ways to support healthy aging at the cellular level.
One compound that has gained attention is Nicotinamide Mononucleotide (NMN), a direct precursor to NAD+—a molecule that plays a role in energy production, DNA repair, and metabolism.
As NAD+ levels naturally decline with age, scientists believe that supplementing with NMN may help support these functions.-v1739208539782.webp)
Some studies suggest NMN might improve mitochondrial function, which is key for maintaining energy and muscle strength (5).
Research published in Cell Metabolism found that NMN supplementation helped older mice maintain stamina and physical endurance, potentially mimicking some of the benefits of exercise (6).
Another study in Nature Aging indicated that NMN may support cognitive function by improving blood flow to the brain (7).
While human research is still developing, early findings suggest NMN could be a helpful addition for those looking to support long-term health.
NMN has also been linked to cardiovascular benefits. Some studies indicate it might help with blood vessel flexibility and circulation—two factors that tend to decline with age (8).
By supporting better blood flow, NMN may contribute to brain health, heart function, and overall vitality. While more research is needed, many experts consider NMN an interesting option for those focused on healthy aging.
If you're looking for a well-formulated NMN supplement, Omre NMN + Resveratrol is worth considering. It combines 500mg of NMN with resveratrol, a polyphenol known for activating sirtuins—enzymes that regulate aging-related pathways.
With 99% purity NMN and 98% purity resveratrol, plus BioPerine® for better absorption, it delivers a research-backed combination designed to support NAD+ levels and cellular health.
Choosing the Right Multivitamin: Factors to Consider
Not all multivitamins are created equal. Here’s what to keep in mind when picking one:
Key Nutrients – Look for vitamin D, calcium, magnesium, and B vitamins, as these are especially important for women over 65.
Absorption – Some forms of vitamins (like methylated B12 and folate) are easier for the body to process.
Dosage – More isn’t always better. Check that amounts align with recommended daily values.
Iron Content – Many women over 65 no longer need extra iron, so make sure it’s not included unless necessary.
Added Benefits – Some formulas include probiotics, omega-3s, or plant-based antioxidants for extra support.
- Pill Size & Format – If you struggle with large tablets, gummies or liquid options may be more convenient.
Other Supplements to Consider for Women Over 65
A well-rounded multivitamin is a great foundation, but some nutrients may require extra attention.
Omega-3 Fatty Acids – May support brain, heart, and joint health. Found in fish oil or algae-based supplements.
Coenzyme Q10 (CoQ10) – Plays a role in energy production and heart health. Levels decline with age.
Probiotics – Can aid digestion and help maintain a balanced gut microbiome.
Magnesium – Supports muscle function, relaxation, and bone health.
Curcumin (Turmeric Extract) – Known for its anti-inflammatory properties, which may help with joint and brain health.
- Collagen – May support skin elasticity, joint health, and bone density.
Diet & Lifestyle Tips for Better Nutrient Absorption
Even the best supplements won’t work well if your body isn’t absorbing them properly. Here are a few simple ways to get the most out of your nutrients:
Pair vitamins with food – Fat-soluble vitamins (A, D, E, K) absorb best when taken with a meal that includes healthy fats.
Limit caffeine around supplements – Coffee and tea can interfere with the absorption of certain minerals like iron and calcium.
Support gut health – A healthy gut microbiome helps absorb nutrients more efficiently. Include fiber, fermented foods, and probiotics.
Stay active – Exercise can improve circulation and help nutrients reach the cells where they’re needed.
Get enough sunlight – Natural light helps the body produce vitamin D, which is important for bones, mood, and immune function.
Drink plenty of water – Hydration is key for digestion and nutrient transport.
Making a few small adjustments can go a long way in helping your body make the most of the vitamins and minerals you take daily.
Conclusion
Staying healthy and energized after 65 isn’t just about taking a multivitamin—it’s about choosing the right one for your needs.
Whether you’re looking for a simple daily option, a whole-food-based formula, or added support for bone, brain, and heart health, there’s a multivitamin that fits.
Beyond that, key supplements like omega-3s, CoQ10, and NMN may offer additional support for aging well. Pairing these with a balanced diet, regular movement, and mindful lifestyle choices can help your body absorb and use nutrients effectively.
If you’re interested in NMN for cellular energy and longevity, Omre NMN + Resveratrol delivers high-purity ingredients at research-backed doses.
Check availability to see if it’s the right fit for your supplement routine.